Effect of alendronate on healing of extraction sockets and healing around implants

J. H. Kim, Y. B. Park, Z. Li, J. S. Shim, H. S. Moon, Hansung Jung, Moon Kyu Chung

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Abstract

Objectives: The purpose of this study was to evaluate the effect of alendronates on healing of extraction sockets and healing around implants in the maxilla of rats. Materials and Methods: Twenty-four Sprague-Dawley rats were used. The rats in bisphosphonate group were subcutaneously injected with alendronate (5.0mg kg --1 ) three times a week for 4weeks. Both sides of the maxillary first molars were extracted, and customized titanium implants (Ø1.5×2.0mm) were placed immediately into one side. Rats were killed at 3, 7, 14, or 28days following surgery. Results: New bone formation in extraction sockets, bone area around the implant site, and bone-implant contact were not delayed in the bisphosphonate group. The tartrate-resistant acid phosphatase positive cell count did not differ between bisphosphonate and control groups; however, empty lacunae were observed significantly more in bisphosphonate group. The differences in empty lacunae were shown at different time points between the implant sites and extraction sites: at 7days after extraction, and at 14 and 28days after implantation. Conclusions: Alendronates seemed to decrease bone resorption but not to decrease bone formation. Empty lacunae were observed significantly more at later time points in implant sites compared to extraction sockets.

Original languageEnglish
Pages (from-to)705-711
Number of pages7
JournalOral Diseases
Volume17
Issue number7
DOIs
Publication statusPublished - 2011 Oct 1

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All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Dentistry(all)

Cite this

Kim, J. H., Park, Y. B., Li, Z., Shim, J. S., Moon, H. S., Jung, H., & Chung, M. K. (2011). Effect of alendronate on healing of extraction sockets and healing around implants. Oral Diseases, 17(7), 705-711. https://doi.org/10.1111/j.1601-0825.2011.01829.x