Effect of Amyloid on Cognitive Performance in Parkinson's Disease and Dementia with Lewy Bodies

Kyoungwon Baik, Hye Ryun Kim, Mincheol Park, Younggun Lee, Han Kyu Na, Young H. Sohn, Joon Kyung Seong, Phil Hyu Lee

Research output: Contribution to journalArticlepeer-review


Background: Concomitant amyloid pathology contributes to the clinical heterogeneity of Lewy body diseases (LBDs). Objective: The objective of this study was to investigate the pattern and effect of amyloid accumulation on cognitive dysfunction in Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Methods: We retrospectively assessed 205 patients with LBD (91 with DLB and 114 with PD) who underwent 18F-florbetaben positron emission tomography and divided them into amyloid-positive and amyloid-negative groups depending on global standardized uptake value ratios (SUVRs). We investigated the effect of group on the regional and global SUVRs using general linear models (GLMs) after controlling for age, sex, cognitive status, and score on the Korean version of the Mini-Mental State Examination. Moreover, the effect of amyloid on cognitive function, depending on the type of LBD, was evaluated using GLMs with interaction analysis. Results: In all evaluated regions including the striatum, the DLB group showed a higher SUVR than the PD group. Among amyloid-positive patients, the DLB group had a higher regional SUVR than the PD group in the frontal and parietal cortices. There was a significant interaction effect between amyloid and disease groups in language and memory function. In patients with PD, global amyloid load was negatively associated with language (B = −2.03; P = 0.010) and memory functions (B = −1.96; P < 0.001). However, amyloid load was not significantly associated with cognitive performance in the DLB group. Conclusions: Although the burden of amyloid was higher in the DLB group, amyloid accumulation was negatively associated with the memory and language functions in the PD group only.

Original languageEnglish
Pages (from-to)278-285
Number of pages8
JournalMovement Disorders
Issue number2
Publication statusPublished - 2023 Feb

Bibliographical note

Funding Information:
: This work was supported by a grant from the Korea Health Technology R&D Project through the Korean Healthy Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HU21C0053) awarded to Phil Hyu Lee. Funding agency

Publisher Copyright:
© 2022 International Parkinson and Movement Disorder Society.

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology


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