Effect of an excipient on the formation of PLGA particles using supercritical fluid

In Il Jung, Seungjoo Haam, Giobin Lim, Jong Hoon Ryu

Research output: Contribution to journalArticle

Abstract

In this study, we employed hydroxypropyl-β-cyclodextrin (HP-β-CD) as an excipient to produce poly(lactic-co-glycolic acid) (PLGA) fine particles by a supercritical fluid process, called aerosol solvent extraction system (ASES), and investigated the effect of HP-β-CD content on the morphology of the particles. The influence of HP-β-CD on the drug release characteristics of paclitaxel-loaded PLGA particles was also evaluated. Fine particles were obtained when the HP-β-CD content in PLGA/HP-β-CD mixtures was greater than 40% and 30%, respectively, for PLGA(75:25) and PLGA(50:50), whereas a film-like precipitate was obtained for lower HP-β-CD content. The release rate for paclitaxel loaded PLGA(75:25)/HP-β-CD particles was found to increase with HP-β-CD content.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalPolymer (Korea)
Volume36
Issue number1
DOIs
Publication statusPublished - 2012 Jan

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Polymers and Plastics
  • Materials Chemistry

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