Effect of angiotensin-converting enzyme inhibitors on phenylephrine responsiveness in patients with valvular heart disease

H. J. Kwak, Younglan Kwak, Y. J. Oh, Y. H. Shim, S. H. Kim, Y. W. Hong

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We studied patients with valvular heart disease to investigate whether chronic preoperative treatment with angiotensin-converting enzyme (ACE) inhibitors modulates the effect of phenylephrine (PE) on anaesthesia-induced hypotension. Sixty-five patients were enrolled in the study and hypotension developed after anaesthesia in 36 (18 in the control group and 18 in the ACE inhibitor group). These patients received PE infusions, which were increased in a stepwise fashion at 10-min intervals. Increased mean arterial pressure due to PE infusion was significant only in the control group. There was no significant difference in pressor response or change in haemodynamic variables with PE infusion between the two groups. Treatment with ACE inhibitors did not increase the incidence of hypotensive episodes or significantly modify pressor response after anaesthesia in patients with valvular heart disease.

Original languageEnglish
Pages (from-to)150-159
Number of pages10
JournalJournal of International Medical Research
Volume33
Issue number2
DOIs
Publication statusPublished - 2005 Jan 1

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Heart Valve Diseases
Phenylephrine
Angiotensin-Converting Enzyme Inhibitors
Anesthesia
Controlled Hypotension
Control Groups
Hemodynamics
Hypotension
Arterial Pressure
Incidence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

Cite this

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abstract = "We studied patients with valvular heart disease to investigate whether chronic preoperative treatment with angiotensin-converting enzyme (ACE) inhibitors modulates the effect of phenylephrine (PE) on anaesthesia-induced hypotension. Sixty-five patients were enrolled in the study and hypotension developed after anaesthesia in 36 (18 in the control group and 18 in the ACE inhibitor group). These patients received PE infusions, which were increased in a stepwise fashion at 10-min intervals. Increased mean arterial pressure due to PE infusion was significant only in the control group. There was no significant difference in pressor response or change in haemodynamic variables with PE infusion between the two groups. Treatment with ACE inhibitors did not increase the incidence of hypotensive episodes or significantly modify pressor response after anaesthesia in patients with valvular heart disease.",
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Effect of angiotensin-converting enzyme inhibitors on phenylephrine responsiveness in patients with valvular heart disease. / Kwak, H. J.; Kwak, Younglan; Oh, Y. J.; Shim, Y. H.; Kim, S. H.; Hong, Y. W.

In: Journal of International Medical Research, Vol. 33, No. 2, 01.01.2005, p. 150-159.

Research output: Contribution to journalArticle

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