Effect of apolipoprotein E polymorphism on the serum lipid and insulin response to whole grain consumption in coronary artery disease patients

Yangsoo Jang, Oh Yoen Kim, Hyun Young Park, Jong Ho Lee, Ji Sun Ham, Ha Jung Ryu

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1 Citation (Scopus)

Abstract

Whether apo E polymorphism influenced serum lipids and insulin response to the isocalorical replacement of refined rice with whole grains was investigated in coronary artery disease (CAD) men with a low-fat diet. CAD men (n=110) were switched from their basal diet (61% carbohydrate and 19% fat) to isoenergetic diet containing 70g whole grain powder (220kcal), as a carbohydrate source of breakfast for 16 weeks. Apo E2 group (n=11) showed higher baseline serum triglyceride than apo E3 group (n=82). Baseline serum concentrations of total and LDL cholesterol and apo B were highest in apo E4 group (n=16), intermediate in apo E3 and lowest in apo E2. Apo E3 groups showed significantly decreases of triglyceride, total and LDL cholesterol and apo B by 12%, 5%, 8% and 8% after 16 weeks, respectively. In apo E4 group, similar decrease of LDL cholesterol and apo B was observed. HDL cholesterol significantly increased by 8% and 15% in apo E3 and E4 groups, respectively. Apo E3 group showed about 9% decrease in fasting insulin and glucose. Apo E genotype modified the serum lipids and insulin response to the isocalorical replacement of refined rice with whole grains in CAD men with a low-fat diet; apo E2 subjects were non-responders, while apo E3 subjects were favorable responders.

Original languageEnglish
Pages (from-to)1463-1473
Number of pages11
JournalNutrition Research
Volume21
Issue number12
DOIs
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

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