Effect of calcium phosphate glass on bone formation in calvarial defects of Sprague-Dawley rats

Hyun Ju Moon, Kyoung Nam Kim, Kwang Mahn Kim, Seong Ho Choi, Chong Kwan Kim, Kee Deog Kim, Racquel Z. Legeros, Yong Keun Lee

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The purpose of this study was to investigate the bone regenerative effect of calcium phosphate glass in vivo. We prepared two different sizes of calcium phosphate glass powder using the system CaO-CaF2-P2O 5-MgO-ZnO; the particle size of the powders were 400 μm and 40 μm. 8 mm calvarial critical-sized defects were created in 60 male Sprague-Dawley rats. The animals were divided into 3 groups of 20 animals each. Each defect was filled with a constant weight of 0.5 g calcium phosphate glass powder mixed with saline. As controls, the defect was left empty. The rats were sacrificed 2 or 8 weeks after postsurgery, and the results were evaluated using radiodensitometric and histological studies; they were also examined histomorphometrically. When the bigger powders with 400 μm particle were grafted, the defects were nearly completely filled with new-formed bone in a clean healing condition after 8 week. When smaller powders with 40 μm particle were transplanted, new bone formation was even lower than the control group due to a lot of inflammatory cell infiltration. It was concluded that the prepared calcium phosphate glass enhanced the new bone formation in the calvarial defect of Sprague-Dawley rats and it is expected to be a good potential materials for hard tissue regeneration. The particle size of the calcium phosphate was crucial; 400 μm particles promoted new bone formation, while 40 μm particles inhibited it because of severe inflammation.

Original languageEnglish
Pages (from-to)807-813
Number of pages7
JournalJournal of Materials Science: Materials in Medicine
Volume17
Issue number9
DOIs
Publication statusPublished - 2006 Sep 1

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Calcium phosphate
Osteogenesis
Powders
Glass
Sprague Dawley Rats
Rats
Bone
Defects
Particle Size
Animals
Particle size
Bone and Bones
Tissue regeneration
Infiltration
Regeneration
calcium phosphate
Inflammation
Weights and Measures
Control Groups

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Moon, Hyun Ju ; Kim, Kyoung Nam ; Kim, Kwang Mahn ; Choi, Seong Ho ; Kim, Chong Kwan ; Kim, Kee Deog ; Legeros, Racquel Z. ; Lee, Yong Keun. / Effect of calcium phosphate glass on bone formation in calvarial defects of Sprague-Dawley rats. In: Journal of Materials Science: Materials in Medicine. 2006 ; Vol. 17, No. 9. pp. 807-813.
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Effect of calcium phosphate glass on bone formation in calvarial defects of Sprague-Dawley rats. / Moon, Hyun Ju; Kim, Kyoung Nam; Kim, Kwang Mahn; Choi, Seong Ho; Kim, Chong Kwan; Kim, Kee Deog; Legeros, Racquel Z.; Lee, Yong Keun.

In: Journal of Materials Science: Materials in Medicine, Vol. 17, No. 9, 01.09.2006, p. 807-813.

Research output: Contribution to journalArticle

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