Effect of calcium phosphate glass on proliferation and differentiation of MG-63 cells in HA scaffolds

Yeon Ung Kim, Racquel Z. Legeros, Kyoung Nam Kim, Kwang Mahn Kim, Yong Keun Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

This study examined the possibility of synthesis of biphasic calcium phosphate by sintering a mixture of hydroxyapatite and calcium phosphate glass. The effect of the concentration of calcium phosphate glass in a mixture on the proliferation and differentiation of MG-63 preosteoblast-like cells in a hydtoxyapatite scaffold was investigated. The addition of 5 wt% of calcium phosphate glass significantly improved the level of attachment, proliferation and differentiation of MG-63 cells onto the hydroxyapatite scaffolds, particularly when the surface was modified with 2% bovine serum albumin (p<0.05). Under these conditions, type I collagen was expressed and the extracellular matrix was formed by 1 week, and the ALP gene was expressed at 4 weeks.

Original languageEnglish
Title of host publicationSupplement to THERMEC 2006, 5th International Conference on PROCESSING and MANUFACTURING OF ADVANCED MATERIALS, THERMEC 2006
Pages731-736
Number of pages6
EditionPART 1
Publication statusPublished - 2007 Dec 1
Event5th International Conference on Processing and Manufacturing of Advanced Materials - THERMEC'2006 - Vancouver, Canada
Duration: 2006 Jul 42006 Jul 8

Publication series

NameMaterials Science Forum
NumberPART 1
Volume539-543
ISSN (Print)0255-5476

Other

Other5th International Conference on Processing and Manufacturing of Advanced Materials - THERMEC'2006
CountryCanada
CityVancouver
Period06/7/406/7/8

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All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Kim, Y. U., Legeros, R. Z., Kim, K. N., Kim, K. M., & Lee, Y. K. (2007). Effect of calcium phosphate glass on proliferation and differentiation of MG-63 cells in HA scaffolds. In Supplement to THERMEC 2006, 5th International Conference on PROCESSING and MANUFACTURING OF ADVANCED MATERIALS, THERMEC 2006 (PART 1 ed., pp. 731-736). (Materials Science Forum; Vol. 539-543, No. PART 1).