TY - GEN
T1 - Effect of calcium phosphate glass on proliferation and differentiation of MG-63 cells in HA scaffolds
AU - Kim, Yeon Ung
AU - Legeros, Racquel Z.
AU - Kim, Kyoung Nam
AU - Kim, Kwang Mahn
AU - Lee, Yong Keun
PY - 2007
Y1 - 2007
N2 - This study examined the possibility of synthesis of biphasic calcium phosphate by sintering a mixture of hydroxyapatite and calcium phosphate glass. The effect of the concentration of calcium phosphate glass in a mixture on the proliferation and differentiation of MG-63 preosteoblast-like cells in a hydtoxyapatite scaffold was investigated. The addition of 5 wt% of calcium phosphate glass significantly improved the level of attachment, proliferation and differentiation of MG-63 cells onto the hydroxyapatite scaffolds, particularly when the surface was modified with 2% bovine serum albumin (p<0.05). Under these conditions, type I collagen was expressed and the extracellular matrix was formed by 1 week, and the ALP gene was expressed at 4 weeks.
AB - This study examined the possibility of synthesis of biphasic calcium phosphate by sintering a mixture of hydroxyapatite and calcium phosphate glass. The effect of the concentration of calcium phosphate glass in a mixture on the proliferation and differentiation of MG-63 preosteoblast-like cells in a hydtoxyapatite scaffold was investigated. The addition of 5 wt% of calcium phosphate glass significantly improved the level of attachment, proliferation and differentiation of MG-63 cells onto the hydroxyapatite scaffolds, particularly when the surface was modified with 2% bovine serum albumin (p<0.05). Under these conditions, type I collagen was expressed and the extracellular matrix was formed by 1 week, and the ALP gene was expressed at 4 weeks.
UR - http://www.scopus.com/inward/record.url?scp=38349192041&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38349192041&partnerID=8YFLogxK
U2 - 10.4028/0-87849-428-6.731
DO - 10.4028/0-87849-428-6.731
M3 - Conference contribution
AN - SCOPUS:38349192041
SN - 0878494286
SN - 9780878494286
T3 - Materials Science Forum
SP - 731
EP - 736
BT - Supplement to THERMEC 2006, 5th International Conference on PROCESSING and MANUFACTURING OF ADVANCED MATERIALS, THERMEC 2006
PB - Trans Tech Publications Ltd
T2 - 5th International Conference on Processing and Manufacturing of Advanced Materials - THERMEC'2006
Y2 - 4 July 2006 through 8 July 2006
ER -