The purpose of this study is to evaluate the effect of chitosan with absorbable collagen sponge (ACS) carrier on bone formation in the rat calvarial defect model. New bone area and defect closure of the chitosan/ACS group were significantly greater than those of the others at 8 weeks postsurgery (p < 0.01). Chitosan reconstituted with ACS has significant potential to induce the regeneration of bone in rat calvarial critical size defects.
Bibliographical noteFunding Information:
This study was supported by a grant from the Korean Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (03-PJ1-PG1-CH08-0001).
All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Physics and Astronomy(all)