Effect of chronic unloading and rehabilitation on human Achilles tendon properties: A velocity-encoded phase-contrast MRI study

Dongsuk Shin, Taija Finni, Sinyeob Ahn, John A. Hodgson, Hae Dong Lee, V. Reggie Edgerton, Shantanu Sinha

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The objective of this study was to measure and monitor changes in Achilles tendon mechanical properties and force production capability of triceps surae muscles after 4 wk of limb suspension and 6 wk of physical rehabilitation. Five healthy volunteers underwent unilateral lower limb suspension followed by weekly physiotherapy. A velocity-encoded, phase-contrast magnetic resonance imaging (VE-PC-MRI) technique was used to estimate the tendon strain as a function of force produced during the submaximal isometric contractions. After limb suspension, triceps surae muscle strength decreased to 53.2 ± 15.6% (mean ± SD) of the presuspension level (P < 0.05). Young's modulus, estimated from the slope of the tendon stress-strain relationship, decreased by 17.1% (from 140.50 ± 29.33 to 119.95 ± 36.07 MPa, P < 0.05), while the tendon transition point, reflecting the "toe region," increased by 55.7% (from 2.2 ± 1.0% to 3.4 ± 1.24%). Muscle strength, tendon stiffness, and transition point recovered to presuspension levels by the end of 6 wk of rehabilitation. Calcaneus movement was significant during the "isometric" contraction, accounting for 52.13 ± 7.63% of the tendon displacement. Tendon cross-sectional area determined from anatomic magnetic resonance axial images remained unchanged, suggesting that the altered tendon elastic modulus and transition point were largely due to material deterioration. The increase in the transition point following chronic unloading as measured by the VE-PC-MRI technique has not been previously reported and offers new insights into the biomechanical changes that may occur in the tendon crimp structure.

Original languageEnglish
Pages (from-to)1179-1186
Number of pages8
JournalJournal of Applied Physiology
Volume105
Issue number4
DOIs
Publication statusPublished - 2008 Oct 1

Fingerprint

Achilles Tendon
Tendons
Rehabilitation
Suspensions
Isometric Contraction
Elastic Modulus
Muscle Strength
Extremities
Magnetic Resonance Imaging
Calcaneus
Toes
Lower Extremity
Healthy Volunteers
Magnetic Resonance Spectroscopy
Muscles

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Shin, Dongsuk ; Finni, Taija ; Ahn, Sinyeob ; Hodgson, John A. ; Lee, Hae Dong ; Edgerton, V. Reggie ; Sinha, Shantanu. / Effect of chronic unloading and rehabilitation on human Achilles tendon properties : A velocity-encoded phase-contrast MRI study. In: Journal of Applied Physiology. 2008 ; Vol. 105, No. 4. pp. 1179-1186.
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abstract = "The objective of this study was to measure and monitor changes in Achilles tendon mechanical properties and force production capability of triceps surae muscles after 4 wk of limb suspension and 6 wk of physical rehabilitation. Five healthy volunteers underwent unilateral lower limb suspension followed by weekly physiotherapy. A velocity-encoded, phase-contrast magnetic resonance imaging (VE-PC-MRI) technique was used to estimate the tendon strain as a function of force produced during the submaximal isometric contractions. After limb suspension, triceps surae muscle strength decreased to 53.2 ± 15.6{\%} (mean ± SD) of the presuspension level (P < 0.05). Young's modulus, estimated from the slope of the tendon stress-strain relationship, decreased by 17.1{\%} (from 140.50 ± 29.33 to 119.95 ± 36.07 MPa, P < 0.05), while the tendon transition point, reflecting the {"}toe region,{"} increased by 55.7{\%} (from 2.2 ± 1.0{\%} to 3.4 ± 1.24{\%}). Muscle strength, tendon stiffness, and transition point recovered to presuspension levels by the end of 6 wk of rehabilitation. Calcaneus movement was significant during the {"}isometric{"} contraction, accounting for 52.13 ± 7.63{\%} of the tendon displacement. Tendon cross-sectional area determined from anatomic magnetic resonance axial images remained unchanged, suggesting that the altered tendon elastic modulus and transition point were largely due to material deterioration. The increase in the transition point following chronic unloading as measured by the VE-PC-MRI technique has not been previously reported and offers new insights into the biomechanical changes that may occur in the tendon crimp structure.",
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Effect of chronic unloading and rehabilitation on human Achilles tendon properties : A velocity-encoded phase-contrast MRI study. / Shin, Dongsuk; Finni, Taija; Ahn, Sinyeob; Hodgson, John A.; Lee, Hae Dong; Edgerton, V. Reggie; Sinha, Shantanu.

In: Journal of Applied Physiology, Vol. 105, No. 4, 01.10.2008, p. 1179-1186.

Research output: Contribution to journalArticle

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