Effect of collagen membrane fixation on ridge volume stability and new bone formation following guided bone regeneration

Jin Young Park, Young Woo Song, Kyung A. Ko, Franz Josef Strauss, Daniel Stefan Thoma, Jung Seok Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To test the effect of membrane fixation on ridge volume stability and new bone formation using guided bone regeneration. Materials and Methods: In eight beagle dogs, after bilateral extraction of the maxillary pre-molars, a box-shaped defect was created on each side. All defect sites were augmented with a particulate bone substitute material, covered with either one of two non-cross-linked collagen membranes (CM1 or CM2) with or without fixation (-F or -UF). Samples were collected after 8 weeks. Histomorphometric and micro-computed tomography analyses were performed. Results: Membrane fixation made no significant difference to the total augmented volume for both membranes (p >.05). Histological data indicated that at the ridge crest the augmented tissue width amounted to 2.4 ± 0.4 mm in the group CM1-F and 2.4 ± 0.5 mm in the group CM1-UF, with no significant difference between the groups. Conversely, in CM2-F the augmented tissue width was significantly larger than in CM2-UF (2.3 ± 0.1 vs. 1.57 ± 0.27, p <.05). Conclusions: Membrane fixation in contained defects failed to improve ridge volume stability regardless of the membrane type. However, it may enhance the width of the augmented ridge at the coronal portion depending on the type of membrane.

Original languageEnglish
Pages (from-to)684-693
Number of pages10
JournalJournal of Clinical Periodontology
Volume49
Issue number7
DOIs
Publication statusPublished - 2022 Jul

Bibliographical note

Funding Information:
The authors thank Hsu Kuo Tien and Kyu‐Jin Hong for their support during the experiments. Franz Strauss is further supported by a grant (20‐054) from the Osteology Foundation, Switzerland.

Funding Information:
National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF‐2022R1A2C2005537) and by a grant from the Korea government (the Ministry of Science and ICT; the Ministry of Trade, Industry and Energy; the Ministry of Health & Welfare; and the Ministry of Food and Drug Safety) (KMDF_PR_20200901_0238).

Publisher Copyright:
© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

All Science Journal Classification (ASJC) codes

  • Periodontics

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