Effect of Costaria costata fucoidan on expression of matrix metalloproteinase-1 promoter, mRNA, and protein

Jung Moon Hee, Sik Park Kyong, Jeong Ku Mi, Sook Lee Myeong, Hoon Jeong Seok, Tatyana I. Imbs, Tatyana N. Zvyagintseva, Svetlana P. Ermakova, Hwan Lee Yong

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Abstract

Fucoidans are sulfated fucosylated polymers from brown algae cell walls. We assessed the inhibitory effects of Costaria costata fucoidan on UVB-induced MMP-1 promoter, mRNA, and protein expression in vitro using the immortalized human keratinocyte (HaCaT) cell line. Pretreatment with fucoidan significantly inhibited MMP-1 protein expression compared to UVB irradiation alone. Fucoidan significantly reduced MMP-1 mRNA expression and inhibited UVB-induced MMP-1 promoter activity by 37.3%, 53.3%, and 58.5% at 0.01, 0.1, and 1 μg/mL, respectively, compared to UVB irradiation alone. C. costata fucoidan may be a potential therapeutic agent to prevent and treat skin photoaging.

Original languageEnglish
Pages (from-to)1731-1734
Number of pages4
JournalJournal of Natural Products
Volume72
Issue number10
DOIs
Publication statusPublished - 2009 Oct 23

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Hee, J. M., Kyong, S. P., Mi, J. K., Myeong, S. L., Seok, H. J., Imbs, T. I., Zvyagintseva, T. N., Ermakova, S. P., & Yong, H. L. (2009). Effect of Costaria costata fucoidan on expression of matrix metalloproteinase-1 promoter, mRNA, and protein. Journal of Natural Products, 72(10), 1731-1734. https://doi.org/10.1021/np800797v