Abstract
Fucoidans are sulfated fucosylated polymers from brown algae cell walls. We assessed the inhibitory effects of Costaria costata fucoidan on UVB-induced MMP-1 promoter, mRNA, and protein expression in vitro using the immortalized human keratinocyte (HaCaT) cell line. Pretreatment with fucoidan significantly inhibited MMP-1 protein expression compared to UVB irradiation alone. Fucoidan significantly reduced MMP-1 mRNA expression and inhibited UVB-induced MMP-1 promoter activity by 37.3%, 53.3%, and 58.5% at 0.01, 0.1, and 1 μg/mL, respectively, compared to UVB irradiation alone. C. costata fucoidan may be a potential therapeutic agent to prevent and treat skin photoaging.
| Original language | English |
|---|---|
| Pages (from-to) | 1731-1734 |
| Number of pages | 4 |
| Journal | Journal of Natural Products |
| Volume | 72 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2009 Oct 23 |
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All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
Cite this
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Effect of Costaria costata fucoidan on expression of matrix metalloproteinase-1 promoter, mRNA, and protein. / Hee, Jung Moon; Kyong, Sik Park; Mi, Jeong Ku; Myeong, Sook Lee; Jeong, Seokhoon; Imbs, Tatyana I.; Zvyagintseva, Tatyana N.; Ermakova, Svetlana P.; Yong, Hwan Lee.
In: Journal of Natural Products, Vol. 72, No. 10, 23.10.2009, p. 1731-1734.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effect of Costaria costata fucoidan on expression of matrix metalloproteinase-1 promoter, mRNA, and protein
AU - Hee, Jung Moon
AU - Kyong, Sik Park
AU - Mi, Jeong Ku
AU - Myeong, Sook Lee
AU - Jeong, Seokhoon
AU - Imbs, Tatyana I.
AU - Zvyagintseva, Tatyana N.
AU - Ermakova, Svetlana P.
AU - Yong, Hwan Lee
PY - 2009/10/23
Y1 - 2009/10/23
N2 - Fucoidans are sulfated fucosylated polymers from brown algae cell walls. We assessed the inhibitory effects of Costaria costata fucoidan on UVB-induced MMP-1 promoter, mRNA, and protein expression in vitro using the immortalized human keratinocyte (HaCaT) cell line. Pretreatment with fucoidan significantly inhibited MMP-1 protein expression compared to UVB irradiation alone. Fucoidan significantly reduced MMP-1 mRNA expression and inhibited UVB-induced MMP-1 promoter activity by 37.3%, 53.3%, and 58.5% at 0.01, 0.1, and 1 μg/mL, respectively, compared to UVB irradiation alone. C. costata fucoidan may be a potential therapeutic agent to prevent and treat skin photoaging.
AB - Fucoidans are sulfated fucosylated polymers from brown algae cell walls. We assessed the inhibitory effects of Costaria costata fucoidan on UVB-induced MMP-1 promoter, mRNA, and protein expression in vitro using the immortalized human keratinocyte (HaCaT) cell line. Pretreatment with fucoidan significantly inhibited MMP-1 protein expression compared to UVB irradiation alone. Fucoidan significantly reduced MMP-1 mRNA expression and inhibited UVB-induced MMP-1 promoter activity by 37.3%, 53.3%, and 58.5% at 0.01, 0.1, and 1 μg/mL, respectively, compared to UVB irradiation alone. C. costata fucoidan may be a potential therapeutic agent to prevent and treat skin photoaging.
UR - http://www.scopus.com/inward/record.url?scp=70350519852&partnerID=8YFLogxK
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U2 - 10.1021/np800797v
DO - 10.1021/np800797v
M3 - Article
VL - 72
SP - 1731
EP - 1734
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 10
ER -