Effect of Costaria costata fucoidan on expression of matrix metalloproteinase-1 promoter, mRNA, and protein

Jung Moon Hee, Sik Park Kyong, Jeong Ku Mi, Sook Lee Myeong, Seokhoon Jeong, Tatyana I. Imbs, Tatyana N. Zvyagintseva, Svetlana P. Ermakova, Hwan Lee Yong

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Fucoidans are sulfated fucosylated polymers from brown algae cell walls. We assessed the inhibitory effects of Costaria costata fucoidan on UVB-induced MMP-1 promoter, mRNA, and protein expression in vitro using the immortalized human keratinocyte (HaCaT) cell line. Pretreatment with fucoidan significantly inhibited MMP-1 protein expression compared to UVB irradiation alone. Fucoidan significantly reduced MMP-1 mRNA expression and inhibited UVB-induced MMP-1 promoter activity by 37.3%, 53.3%, and 58.5% at 0.01, 0.1, and 1 μg/mL, respectively, compared to UVB irradiation alone. C. costata fucoidan may be a potential therapeutic agent to prevent and treat skin photoaging.

Original languageEnglish
Pages (from-to)1731-1734
Number of pages4
JournalJournal of Natural Products
Volume72
Issue number10
DOIs
Publication statusPublished - 2009 Oct 23

Fingerprint

Matrix Metalloproteinase 1
Matrix Metalloproteinases
Messenger RNA
Proteins
Cells
Irradiation
Phaeophyta
Skin Aging
Algae
Keratinocytes
Cell Wall
Skin
Polymers
fucoidan
Cell Line

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Hee, Jung Moon ; Kyong, Sik Park ; Mi, Jeong Ku ; Myeong, Sook Lee ; Jeong, Seokhoon ; Imbs, Tatyana I. ; Zvyagintseva, Tatyana N. ; Ermakova, Svetlana P. ; Yong, Hwan Lee. / Effect of Costaria costata fucoidan on expression of matrix metalloproteinase-1 promoter, mRNA, and protein. In: Journal of Natural Products. 2009 ; Vol. 72, No. 10. pp. 1731-1734.
@article{c18405039bcd4be49d8e4ebb7004efc0,
title = "Effect of Costaria costata fucoidan on expression of matrix metalloproteinase-1 promoter, mRNA, and protein",
abstract = "Fucoidans are sulfated fucosylated polymers from brown algae cell walls. We assessed the inhibitory effects of Costaria costata fucoidan on UVB-induced MMP-1 promoter, mRNA, and protein expression in vitro using the immortalized human keratinocyte (HaCaT) cell line. Pretreatment with fucoidan significantly inhibited MMP-1 protein expression compared to UVB irradiation alone. Fucoidan significantly reduced MMP-1 mRNA expression and inhibited UVB-induced MMP-1 promoter activity by 37.3{\%}, 53.3{\%}, and 58.5{\%} at 0.01, 0.1, and 1 μg/mL, respectively, compared to UVB irradiation alone. C. costata fucoidan may be a potential therapeutic agent to prevent and treat skin photoaging.",
author = "Hee, {Jung Moon} and Kyong, {Sik Park} and Mi, {Jeong Ku} and Myeong, {Sook Lee} and Seokhoon Jeong and Imbs, {Tatyana I.} and Zvyagintseva, {Tatyana N.} and Ermakova, {Svetlana P.} and Yong, {Hwan Lee}",
year = "2009",
month = "10",
day = "23",
doi = "10.1021/np800797v",
language = "English",
volume = "72",
pages = "1731--1734",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "10",

}

Hee, JM, Kyong, SP, Mi, JK, Myeong, SL, Jeong, S, Imbs, TI, Zvyagintseva, TN, Ermakova, SP & Yong, HL 2009, 'Effect of Costaria costata fucoidan on expression of matrix metalloproteinase-1 promoter, mRNA, and protein', Journal of Natural Products, vol. 72, no. 10, pp. 1731-1734. https://doi.org/10.1021/np800797v

Effect of Costaria costata fucoidan on expression of matrix metalloproteinase-1 promoter, mRNA, and protein. / Hee, Jung Moon; Kyong, Sik Park; Mi, Jeong Ku; Myeong, Sook Lee; Jeong, Seokhoon; Imbs, Tatyana I.; Zvyagintseva, Tatyana N.; Ermakova, Svetlana P.; Yong, Hwan Lee.

In: Journal of Natural Products, Vol. 72, No. 10, 23.10.2009, p. 1731-1734.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of Costaria costata fucoidan on expression of matrix metalloproteinase-1 promoter, mRNA, and protein

AU - Hee, Jung Moon

AU - Kyong, Sik Park

AU - Mi, Jeong Ku

AU - Myeong, Sook Lee

AU - Jeong, Seokhoon

AU - Imbs, Tatyana I.

AU - Zvyagintseva, Tatyana N.

AU - Ermakova, Svetlana P.

AU - Yong, Hwan Lee

PY - 2009/10/23

Y1 - 2009/10/23

N2 - Fucoidans are sulfated fucosylated polymers from brown algae cell walls. We assessed the inhibitory effects of Costaria costata fucoidan on UVB-induced MMP-1 promoter, mRNA, and protein expression in vitro using the immortalized human keratinocyte (HaCaT) cell line. Pretreatment with fucoidan significantly inhibited MMP-1 protein expression compared to UVB irradiation alone. Fucoidan significantly reduced MMP-1 mRNA expression and inhibited UVB-induced MMP-1 promoter activity by 37.3%, 53.3%, and 58.5% at 0.01, 0.1, and 1 μg/mL, respectively, compared to UVB irradiation alone. C. costata fucoidan may be a potential therapeutic agent to prevent and treat skin photoaging.

AB - Fucoidans are sulfated fucosylated polymers from brown algae cell walls. We assessed the inhibitory effects of Costaria costata fucoidan on UVB-induced MMP-1 promoter, mRNA, and protein expression in vitro using the immortalized human keratinocyte (HaCaT) cell line. Pretreatment with fucoidan significantly inhibited MMP-1 protein expression compared to UVB irradiation alone. Fucoidan significantly reduced MMP-1 mRNA expression and inhibited UVB-induced MMP-1 promoter activity by 37.3%, 53.3%, and 58.5% at 0.01, 0.1, and 1 μg/mL, respectively, compared to UVB irradiation alone. C. costata fucoidan may be a potential therapeutic agent to prevent and treat skin photoaging.

UR - http://www.scopus.com/inward/record.url?scp=70350519852&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350519852&partnerID=8YFLogxK

U2 - 10.1021/np800797v

DO - 10.1021/np800797v

M3 - Article

VL - 72

SP - 1731

EP - 1734

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 10

ER -