Effect of Costaria costata fucoidan on expression of matrix metalloproteinase-1 promoter, mRNA, and protein

Jung Moon Hee; Sik Park Kyong; Jeong Ku Mi; Sook Lee Myeong; Hoon Jeong Seok; Tatyana I. Imbs; Tatyana N. Zvyagintseva; Svetlana P. Ermakova; Hwan Lee Yong

doi:10.1021/np800797v

Effect of Costaria costata fucoidan on expression of matrix metalloproteinase-1 promoter, mRNA, and protein

Jung Moon Hee, Sik Park Kyong, Jeong Ku Mi, Sook Lee Myeong, Hoon Jeong Seok, Tatyana I. Imbs, Tatyana N. Zvyagintseva, Svetlana P. Ermakova, Hwan Lee Yong

Department of Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Fucoidans are sulfated fucosylated polymers from brown algae cell walls. We assessed the inhibitory effects of Costaria costata fucoidan on UVB-induced MMP-1 promoter, mRNA, and protein expression in vitro using the immortalized human keratinocyte (HaCaT) cell line. Pretreatment with fucoidan significantly inhibited MMP-1 protein expression compared to UVB irradiation alone. Fucoidan significantly reduced MMP-1 mRNA expression and inhibited UVB-induced MMP-1 promoter activity by 37.3%, 53.3%, and 58.5% at 0.01, 0.1, and 1 μg/mL, respectively, compared to UVB irradiation alone. C. costata fucoidan may be a potential therapeutic agent to prevent and treat skin photoaging.

Original language	English
Pages (from-to)	1731-1734
Number of pages	4
Journal	Journal of Natural Products
Volume	72
Issue number	10
DOIs	https://doi.org/10.1021/np800797v
Publication status	Published - 2009 Oct 23

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Effect of Costaria costata fucoidan on expression of matrix metalloproteinase-1 promoter, mRNA, and protein",

abstract = "Fucoidans are sulfated fucosylated polymers from brown algae cell walls. We assessed the inhibitory effects of Costaria costata fucoidan on UVB-induced MMP-1 promoter, mRNA, and protein expression in vitro using the immortalized human keratinocyte (HaCaT) cell line. Pretreatment with fucoidan significantly inhibited MMP-1 protein expression compared to UVB irradiation alone. Fucoidan significantly reduced MMP-1 mRNA expression and inhibited UVB-induced MMP-1 promoter activity by 37.3%, 53.3%, and 58.5% at 0.01, 0.1, and 1 μg/mL, respectively, compared to UVB irradiation alone. C. costata fucoidan may be a potential therapeutic agent to prevent and treat skin photoaging.",

author = "Hee, {Jung Moon} and Kyong, {Sik Park} and Mi, {Jeong Ku} and Myeong, {Sook Lee} and Seok, {Hoon Jeong} and Imbs, {Tatyana I.} and Zvyagintseva, {Tatyana N.} and Ermakova, {Svetlana P.} and Yong, {Hwan Lee}",

year = "2009",

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language = "English",

volume = "72",

pages = "1731--1734",

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Effect of Costaria costata fucoidan on expression of matrix metalloproteinase-1 promoter, mRNA, and protein. / Hee, Jung Moon; Kyong, Sik Park; Mi, Jeong Ku; Myeong, Sook Lee; Seok, Hoon Jeong; Imbs, Tatyana I.; Zvyagintseva, Tatyana N.; Ermakova, Svetlana P.; Yong, Hwan Lee.

In: Journal of Natural Products, Vol. 72, No. 10, 23.10.2009, p. 1731-1734.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effect of Costaria costata fucoidan on expression of matrix metalloproteinase-1 promoter, mRNA, and protein

AU - Hee, Jung Moon

AU - Kyong, Sik Park

AU - Mi, Jeong Ku

AU - Myeong, Sook Lee

AU - Seok, Hoon Jeong

AU - Imbs, Tatyana I.

AU - Zvyagintseva, Tatyana N.

AU - Ermakova, Svetlana P.

AU - Yong, Hwan Lee

PY - 2009/10/23

Y1 - 2009/10/23

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AB - Fucoidans are sulfated fucosylated polymers from brown algae cell walls. We assessed the inhibitory effects of Costaria costata fucoidan on UVB-induced MMP-1 promoter, mRNA, and protein expression in vitro using the immortalized human keratinocyte (HaCaT) cell line. Pretreatment with fucoidan significantly inhibited MMP-1 protein expression compared to UVB irradiation alone. Fucoidan significantly reduced MMP-1 mRNA expression and inhibited UVB-induced MMP-1 promoter activity by 37.3%, 53.3%, and 58.5% at 0.01, 0.1, and 1 μg/mL, respectively, compared to UVB irradiation alone. C. costata fucoidan may be a potential therapeutic agent to prevent and treat skin photoaging.

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