Effect of CuCl2 concentration on the aggregation and mineralization of Tobacco mosaic virus biotemplate

Sang Yup Lee, James N. Culver, Michael T. Harris

Research output: Contribution to journalArticle

32 Citations (Scopus)


Aggregation of the biotemplates in mineralization processes is a considerable obstacle in preparing well-dispersed bio-inorganic hybrid materials. In this study, aggregation and mineralization of Tobacco mosaic virus (TMV) biotemplates were investigated as a function of the copper precursor (CuCl2) concentration. The mean hydrodynamic radius of TMV in an aqueous CuCl2 solution was determined by dynamic light scattering for the monitoring of the TMV aggregation. At CuCl2 concentration of 0.5 mM or higher, the mean hydrodynamic radius of TMV increased dramatically indicating aggregation of the TMV particles. Numerical calculations on the long-range interaction energy between parallel model TMV particles agreed with the experimental observations for the TMV aggregation. Mineralization of copper precursors on the TMV biotemplates was achieved only at the CuCl2 concentrations that induced considerable aggregation of the biotemplate. From the numerical calculations and experimental results, it was concluded that a dense copper cluster deposition cannot be achieved without aggregation of TMV templates.

Original languageEnglish
Pages (from-to)554-560
Number of pages7
JournalJournal of Colloid and Interface Science
Issue number2
Publication statusPublished - 2006 May 15

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry

Fingerprint Dive into the research topics of 'Effect of CuCl<sub>2</sub> concentration on the aggregation and mineralization of Tobacco mosaic virus biotemplate'. Together they form a unique fingerprint.

  • Cite this