Effect of dexamethasone in combination with caudal analgesia on postoperative pain control in day-case paediatric orchiopexy

J. Y. Hong, S. W. Han, W. O. Kim, E. J. Kim, H. K. Kil

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

BackgroundDexamethasone has a powerful anti-inflammatory action and has demonstrated reduced morbidity after surgery. The aim of this study was to examine the effects of a single i.v. dose of dexamethasone in combination with caudal block on postoperative analgesia in children.MethodsSeventy-seven children (aged 1-5 yr) undergoing day-case orchiopexy were included in this prospective, randomized, double-blinded study at a single university hospital. After inhalation induction of general anaesthesia, children received either dexamethasone 0.5 mg kg-1 (maximum 10 mg) (n=39) or the same volume of saline (n=38) i.v. A caudal anaesthetic block was then performed using 1.5 ml kg-1 of ropivacaine 0.15 in all patients. After surgery, rescue analgesic consumption, pain scores, and adverse effects were evaluated for 24 h.ResultsSignificantly, fewer patients in the dexamethasone group required fentanyl for rescue analgesia (7.9 vs 38.5) in the post-anaesthetic care unit or acetaminophen (23.7 vs 64.1) after discharge compared with the control group. The time to first administration of oral acetaminophen was significantly longer in the dexamethasone group (646 vs 430 min). Postoperative pain scores were lower in the dexamethasone group and the incidence of adverse effects was similar in both groups.ConclusionsIntravenous dexamethasone 0.5 mg kg -1 in combination with a caudal block augmented the intensity and duration of postoperative analgesia without adverse effects in children undergoing day-case paediatric orchiopexy.Trial registration: ClinicalTrials.gov. The number of registration: NCT01041378.

Original languageEnglish
Pages (from-to)506-510
Number of pages5
JournalBritish Journal of Anaesthesia
Volume105
Issue number4
DOIs
Publication statusPublished - 2010 Oct

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Orchiopexy
Postoperative Pain
Analgesia
Dexamethasone
Pediatrics
Acetaminophen
Anesthetics
Fentanyl
General Anesthesia
Inhalation
Oral Administration
Analgesics
Anti-Inflammatory Agents
Morbidity
Pain
Control Groups
Incidence

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

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title = "Effect of dexamethasone in combination with caudal analgesia on postoperative pain control in day-case paediatric orchiopexy",
abstract = "BackgroundDexamethasone has a powerful anti-inflammatory action and has demonstrated reduced morbidity after surgery. The aim of this study was to examine the effects of a single i.v. dose of dexamethasone in combination with caudal block on postoperative analgesia in children.MethodsSeventy-seven children (aged 1-5 yr) undergoing day-case orchiopexy were included in this prospective, randomized, double-blinded study at a single university hospital. After inhalation induction of general anaesthesia, children received either dexamethasone 0.5 mg kg-1 (maximum 10 mg) (n=39) or the same volume of saline (n=38) i.v. A caudal anaesthetic block was then performed using 1.5 ml kg-1 of ropivacaine 0.15 in all patients. After surgery, rescue analgesic consumption, pain scores, and adverse effects were evaluated for 24 h.ResultsSignificantly, fewer patients in the dexamethasone group required fentanyl for rescue analgesia (7.9 vs 38.5) in the post-anaesthetic care unit or acetaminophen (23.7 vs 64.1) after discharge compared with the control group. The time to first administration of oral acetaminophen was significantly longer in the dexamethasone group (646 vs 430 min). Postoperative pain scores were lower in the dexamethasone group and the incidence of adverse effects was similar in both groups.ConclusionsIntravenous dexamethasone 0.5 mg kg -1 in combination with a caudal block augmented the intensity and duration of postoperative analgesia without adverse effects in children undergoing day-case paediatric orchiopexy.Trial registration: ClinicalTrials.gov. The number of registration: NCT01041378.",
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Effect of dexamethasone in combination with caudal analgesia on postoperative pain control in day-case paediatric orchiopexy. / Hong, J. Y.; Han, S. W.; Kim, W. O.; Kim, E. J.; Kil, H. K.

In: British Journal of Anaesthesia, Vol. 105, No. 4, 10.2010, p. 506-510.

Research output: Contribution to journalArticle

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T1 - Effect of dexamethasone in combination with caudal analgesia on postoperative pain control in day-case paediatric orchiopexy

AU - Hong, J. Y.

AU - Han, S. W.

AU - Kim, W. O.

AU - Kim, E. J.

AU - Kil, H. K.

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N2 - BackgroundDexamethasone has a powerful anti-inflammatory action and has demonstrated reduced morbidity after surgery. The aim of this study was to examine the effects of a single i.v. dose of dexamethasone in combination with caudal block on postoperative analgesia in children.MethodsSeventy-seven children (aged 1-5 yr) undergoing day-case orchiopexy were included in this prospective, randomized, double-blinded study at a single university hospital. After inhalation induction of general anaesthesia, children received either dexamethasone 0.5 mg kg-1 (maximum 10 mg) (n=39) or the same volume of saline (n=38) i.v. A caudal anaesthetic block was then performed using 1.5 ml kg-1 of ropivacaine 0.15 in all patients. After surgery, rescue analgesic consumption, pain scores, and adverse effects were evaluated for 24 h.ResultsSignificantly, fewer patients in the dexamethasone group required fentanyl for rescue analgesia (7.9 vs 38.5) in the post-anaesthetic care unit or acetaminophen (23.7 vs 64.1) after discharge compared with the control group. The time to first administration of oral acetaminophen was significantly longer in the dexamethasone group (646 vs 430 min). Postoperative pain scores were lower in the dexamethasone group and the incidence of adverse effects was similar in both groups.ConclusionsIntravenous dexamethasone 0.5 mg kg -1 in combination with a caudal block augmented the intensity and duration of postoperative analgesia without adverse effects in children undergoing day-case paediatric orchiopexy.Trial registration: ClinicalTrials.gov. The number of registration: NCT01041378.

AB - BackgroundDexamethasone has a powerful anti-inflammatory action and has demonstrated reduced morbidity after surgery. The aim of this study was to examine the effects of a single i.v. dose of dexamethasone in combination with caudal block on postoperative analgesia in children.MethodsSeventy-seven children (aged 1-5 yr) undergoing day-case orchiopexy were included in this prospective, randomized, double-blinded study at a single university hospital. After inhalation induction of general anaesthesia, children received either dexamethasone 0.5 mg kg-1 (maximum 10 mg) (n=39) or the same volume of saline (n=38) i.v. A caudal anaesthetic block was then performed using 1.5 ml kg-1 of ropivacaine 0.15 in all patients. After surgery, rescue analgesic consumption, pain scores, and adverse effects were evaluated for 24 h.ResultsSignificantly, fewer patients in the dexamethasone group required fentanyl for rescue analgesia (7.9 vs 38.5) in the post-anaesthetic care unit or acetaminophen (23.7 vs 64.1) after discharge compared with the control group. The time to first administration of oral acetaminophen was significantly longer in the dexamethasone group (646 vs 430 min). Postoperative pain scores were lower in the dexamethasone group and the incidence of adverse effects was similar in both groups.ConclusionsIntravenous dexamethasone 0.5 mg kg -1 in combination with a caudal block augmented the intensity and duration of postoperative analgesia without adverse effects in children undergoing day-case paediatric orchiopexy.Trial registration: ClinicalTrials.gov. The number of registration: NCT01041378.

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