Effect of different hydroxyapatite:β-tricalcium phosphate ratios on the osteoconductivity of biphasic calcium phosphate in the rabbit sinus model

Hyun Chang Lim, Ming Lan Zhang, Jung Seok Lee, Ui-Won Jung, Seongho Choi

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15 Citations (Scopus)

Abstract

Purpose: This study compared the volume stability and bone-forming capacity of biphasic calcium phosphate (BCP) with a high versus a low ratio of β-tricalcium phosphate (β-TCP) relative to hydroxyapatite (HA), ie, 70:30 vs 30:70, in the rabbit sinus model. Materials and Methods: Bilateral sinus windows were created in eight adult New Zealand white rabbits (2.5 to 3.5 kg); each sinus in each rabbit was assigned to one of two experimental BCP groups according to the HA:β-TCP ratio. One sinus was grafted with BCP with a high ratio of β-TCP (30:70; TCP70), and the contralateral sinus was grafted with BCP with a low ratio of β-TCP (70:30; TCP30). The animals were sacrificed after 2 weeks (n = 4) or 8 weeks (n = 4) of healing. Biopsy specimens were harvested and evaluated histologically, histomorphometrically, and with microcomputed tomography. Results: The bone volume did not differ significantly between the two groups at each healing point, or between 2 and 8 weeks of healing in both groups. The amount of new bone increased significantly between 2 and 8 weeks of healing in both groups, and it did not differ significantly between the TCP30 and TCP70 groups. The residual material was significantly more resorbed in the TCP70 group than in the TCP30 group at both 2 and 8 weeks. In the TCP70 group, a greater number of multinucleated giant cells were observed at both weeks. The bone-to-residual material contact ratio did not differ significantly between the two groups. Conclusion: The volume stability and osteoconductive capacity of BCP with an HA:β-TCP ratio of 30:70 was comparable to that with an HA:β-TCP ratio of 70:30. Thus, within the limitations of this study, it can be argued that BCP with an HA:β-TCP ratio of 30:70 can be successfully used for sinus augmentation.

Original languageEnglish
Pages (from-to)65-72
Number of pages8
JournalInternational Journal of Oral and Maxillofacial Implants
Volume30
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

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Durapatite
Rabbits
Bone and Bones
X-Ray Microtomography
Giant Cells
hydroxyapatite-beta tricalcium phosphate
tricalcium phosphate
Biopsy

All Science Journal Classification (ASJC) codes

  • Oral Surgery

Cite this

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title = "Effect of different hydroxyapatite:β-tricalcium phosphate ratios on the osteoconductivity of biphasic calcium phosphate in the rabbit sinus model",
abstract = "Purpose: This study compared the volume stability and bone-forming capacity of biphasic calcium phosphate (BCP) with a high versus a low ratio of β-tricalcium phosphate (β-TCP) relative to hydroxyapatite (HA), ie, 70:30 vs 30:70, in the rabbit sinus model. Materials and Methods: Bilateral sinus windows were created in eight adult New Zealand white rabbits (2.5 to 3.5 kg); each sinus in each rabbit was assigned to one of two experimental BCP groups according to the HA:β-TCP ratio. One sinus was grafted with BCP with a high ratio of β-TCP (30:70; TCP70), and the contralateral sinus was grafted with BCP with a low ratio of β-TCP (70:30; TCP30). The animals were sacrificed after 2 weeks (n = 4) or 8 weeks (n = 4) of healing. Biopsy specimens were harvested and evaluated histologically, histomorphometrically, and with microcomputed tomography. Results: The bone volume did not differ significantly between the two groups at each healing point, or between 2 and 8 weeks of healing in both groups. The amount of new bone increased significantly between 2 and 8 weeks of healing in both groups, and it did not differ significantly between the TCP30 and TCP70 groups. The residual material was significantly more resorbed in the TCP70 group than in the TCP30 group at both 2 and 8 weeks. In the TCP70 group, a greater number of multinucleated giant cells were observed at both weeks. The bone-to-residual material contact ratio did not differ significantly between the two groups. Conclusion: The volume stability and osteoconductive capacity of BCP with an HA:β-TCP ratio of 30:70 was comparable to that with an HA:β-TCP ratio of 70:30. Thus, within the limitations of this study, it can be argued that BCP with an HA:β-TCP ratio of 30:70 can be successfully used for sinus augmentation.",
author = "Lim, {Hyun Chang} and Zhang, {Ming Lan} and Lee, {Jung Seok} and Ui-Won Jung and Seongho Choi",
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T1 - Effect of different hydroxyapatite:β-tricalcium phosphate ratios on the osteoconductivity of biphasic calcium phosphate in the rabbit sinus model

AU - Lim, Hyun Chang

AU - Zhang, Ming Lan

AU - Lee, Jung Seok

AU - Jung, Ui-Won

AU - Choi, Seongho

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Purpose: This study compared the volume stability and bone-forming capacity of biphasic calcium phosphate (BCP) with a high versus a low ratio of β-tricalcium phosphate (β-TCP) relative to hydroxyapatite (HA), ie, 70:30 vs 30:70, in the rabbit sinus model. Materials and Methods: Bilateral sinus windows were created in eight adult New Zealand white rabbits (2.5 to 3.5 kg); each sinus in each rabbit was assigned to one of two experimental BCP groups according to the HA:β-TCP ratio. One sinus was grafted with BCP with a high ratio of β-TCP (30:70; TCP70), and the contralateral sinus was grafted with BCP with a low ratio of β-TCP (70:30; TCP30). The animals were sacrificed after 2 weeks (n = 4) or 8 weeks (n = 4) of healing. Biopsy specimens were harvested and evaluated histologically, histomorphometrically, and with microcomputed tomography. Results: The bone volume did not differ significantly between the two groups at each healing point, or between 2 and 8 weeks of healing in both groups. The amount of new bone increased significantly between 2 and 8 weeks of healing in both groups, and it did not differ significantly between the TCP30 and TCP70 groups. The residual material was significantly more resorbed in the TCP70 group than in the TCP30 group at both 2 and 8 weeks. In the TCP70 group, a greater number of multinucleated giant cells were observed at both weeks. The bone-to-residual material contact ratio did not differ significantly between the two groups. Conclusion: The volume stability and osteoconductive capacity of BCP with an HA:β-TCP ratio of 30:70 was comparable to that with an HA:β-TCP ratio of 70:30. Thus, within the limitations of this study, it can be argued that BCP with an HA:β-TCP ratio of 30:70 can be successfully used for sinus augmentation.

AB - Purpose: This study compared the volume stability and bone-forming capacity of biphasic calcium phosphate (BCP) with a high versus a low ratio of β-tricalcium phosphate (β-TCP) relative to hydroxyapatite (HA), ie, 70:30 vs 30:70, in the rabbit sinus model. Materials and Methods: Bilateral sinus windows were created in eight adult New Zealand white rabbits (2.5 to 3.5 kg); each sinus in each rabbit was assigned to one of two experimental BCP groups according to the HA:β-TCP ratio. One sinus was grafted with BCP with a high ratio of β-TCP (30:70; TCP70), and the contralateral sinus was grafted with BCP with a low ratio of β-TCP (70:30; TCP30). The animals were sacrificed after 2 weeks (n = 4) or 8 weeks (n = 4) of healing. Biopsy specimens were harvested and evaluated histologically, histomorphometrically, and with microcomputed tomography. Results: The bone volume did not differ significantly between the two groups at each healing point, or between 2 and 8 weeks of healing in both groups. The amount of new bone increased significantly between 2 and 8 weeks of healing in both groups, and it did not differ significantly between the TCP30 and TCP70 groups. The residual material was significantly more resorbed in the TCP70 group than in the TCP30 group at both 2 and 8 weeks. In the TCP70 group, a greater number of multinucleated giant cells were observed at both weeks. The bone-to-residual material contact ratio did not differ significantly between the two groups. Conclusion: The volume stability and osteoconductive capacity of BCP with an HA:β-TCP ratio of 30:70 was comparable to that with an HA:β-TCP ratio of 70:30. Thus, within the limitations of this study, it can be argued that BCP with an HA:β-TCP ratio of 30:70 can be successfully used for sinus augmentation.

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