Abstract
Etoposide-induced 2.4 kb transcript (EI24, also known as PIG8) is a p53 target gene involved in cell growth suppression and apoptosis and known to be frequently altered in human cancers. Although EI24 expression is decreased in various cancers and is associated with colorectal cancer progression and metastasis, the physiological function of EI24 in colorectal cancer is yet unclear. We generated an Ei24 conditional transgenic (Tg) mouse to study the therapeutic effects of Ei24 in vivo and evaluated whether Ei24 plays a role of a tumor suppressor using Ei24 Tg mouse crossed with ApcMin/+ mouse, which develops multiple intestinal adenomas. The overexpression of Ei24 failed to cause any notable difference in the number of polyps, lengths of the intestine and spleen, and survival rate between ApcMin/+ and ApcMin/+ Ei24 Tg mice. Ei24 plays no significant role in colon cancer caused by the substitutional mutation of Apc in mice. Therefore, our result dismisses the hypothesized direct link between ApcMin/+ mutation and Ei24 expression in colorectal cancer model.
| Original language | English |
|---|---|
| Pages (from-to) | 1087-1092 |
| Number of pages | 6 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 514 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2019 Jul 5 |
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All Science Journal Classification (ASJC) codes
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology
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Effect of EI24 expression on the tumorigenesis of ApcMin/+ colorectal cancer mouse model. / Nam, Tae Wook; Park, Song Yi; Lee, Jae Hoon; Roh, Jae il; Lee, Han Woong.
In: Biochemical and Biophysical Research Communications, Vol. 514, No. 4, 05.07.2019, p. 1087-1092.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effect of EI24 expression on the tumorigenesis of ApcMin/+ colorectal cancer mouse model
AU - Nam, Tae Wook
AU - Park, Song Yi
AU - Lee, Jae Hoon
AU - Roh, Jae il
AU - Lee, Han Woong
PY - 2019/7/5
Y1 - 2019/7/5
N2 - Etoposide-induced 2.4 kb transcript (EI24, also known as PIG8) is a p53 target gene involved in cell growth suppression and apoptosis and known to be frequently altered in human cancers. Although EI24 expression is decreased in various cancers and is associated with colorectal cancer progression and metastasis, the physiological function of EI24 in colorectal cancer is yet unclear. We generated an Ei24 conditional transgenic (Tg) mouse to study the therapeutic effects of Ei24 in vivo and evaluated whether Ei24 plays a role of a tumor suppressor using Ei24 Tg mouse crossed with ApcMin/+ mouse, which develops multiple intestinal adenomas. The overexpression of Ei24 failed to cause any notable difference in the number of polyps, lengths of the intestine and spleen, and survival rate between ApcMin/+ and ApcMin/+ Ei24 Tg mice. Ei24 plays no significant role in colon cancer caused by the substitutional mutation of Apc in mice. Therefore, our result dismisses the hypothesized direct link between ApcMin/+ mutation and Ei24 expression in colorectal cancer model.
AB - Etoposide-induced 2.4 kb transcript (EI24, also known as PIG8) is a p53 target gene involved in cell growth suppression and apoptosis and known to be frequently altered in human cancers. Although EI24 expression is decreased in various cancers and is associated with colorectal cancer progression and metastasis, the physiological function of EI24 in colorectal cancer is yet unclear. We generated an Ei24 conditional transgenic (Tg) mouse to study the therapeutic effects of Ei24 in vivo and evaluated whether Ei24 plays a role of a tumor suppressor using Ei24 Tg mouse crossed with ApcMin/+ mouse, which develops multiple intestinal adenomas. The overexpression of Ei24 failed to cause any notable difference in the number of polyps, lengths of the intestine and spleen, and survival rate between ApcMin/+ and ApcMin/+ Ei24 Tg mice. Ei24 plays no significant role in colon cancer caused by the substitutional mutation of Apc in mice. Therefore, our result dismisses the hypothesized direct link between ApcMin/+ mutation and Ei24 expression in colorectal cancer model.
UR - http://www.scopus.com/inward/record.url?scp=85065524056&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065524056&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2019.04.186
DO - 10.1016/j.bbrc.2019.04.186
M3 - Article
C2 - 31097220
AN - SCOPUS:85065524056
VL - 514
SP - 1087
EP - 1092
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 4
ER -