Effect of End-Stage Renal Disease on Rate of Progression of Aortic Stenosis

Darae Kim, ChiYoung Shim, Geu Ru Hong, In Jeong Cho, Hyuk-Jae Chang, Jong Won Ha, Namsik Chung

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

This study aimed to investigate the progression of mild-to-moderate aortic stenosis (AS) in patients with end-stage renal disease (ESRD) and determine its metabolic and hemodynamic contributors and clinical outcomes. A total of 74 patients with ESRD (50 men, age 72 ± 11 years) with mild-to-moderate AS were compared with 79 age- and gender-matched controls with normal kidney function. Clinical, laboratory, and echocardiographic features and clinical outcomes including aortic valve (AV) intervention, hospitalization due to heart failure, and cardiovascular death were analyzed. Patients with ESRD were divided into 2 subgroups according to their rate of AV area changes (group 1 [n = 28], rapid progression; and group 2 [n = 46], slow progression). Progression in the degree of AS was noted in 38% of patients with ESRD and 18% of controls (p <0.01) during comparable echocardiographic follow-up durations (29 ± 15 vs 27 ± 24 months, respectively, p = 0.57). In ESRD, patients in group 1 were older (p <0.01) with higher baseline log parathyroid hormone (p <0.01) and larger stroke volume (p = 0.03) than those in group 2. During clinical follow-up (48 ± 23 months), patients in group 1 showed poorer clinical outcomes than those in group 2 and controls (log-rank p <0.01). Age, left atrial volume index ≥42 ml/m2, and annual increases of peak pressure gradient across the AV (mm Hg/year) demonstrated additive predictive values for prognosis. AS in ESRD progresses in an accelerated manner along with higher metabolic and hemodynamic loads on AV compared with those with normal kidney function. Accelerated progression of mild-to-moderate AS in ESRD results in poor prognosis.

Original languageEnglish
Pages (from-to)1972-1977
Number of pages6
JournalAmerican Journal of Cardiology
Volume117
Issue number12
DOIs
Publication statusPublished - 2016 Jun 15

Fingerprint

Aortic Valve Stenosis
Chronic Kidney Failure
Aortic Valve
Hemodynamics
Kidney
Parathyroid Hormone
Stroke Volume
Hospitalization
Heart Failure
Pressure
Control Groups

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Kim, Darae ; Shim, ChiYoung ; Hong, Geu Ru ; Cho, In Jeong ; Chang, Hyuk-Jae ; Ha, Jong Won ; Chung, Namsik. / Effect of End-Stage Renal Disease on Rate of Progression of Aortic Stenosis. In: American Journal of Cardiology. 2016 ; Vol. 117, No. 12. pp. 1972-1977.
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abstract = "This study aimed to investigate the progression of mild-to-moderate aortic stenosis (AS) in patients with end-stage renal disease (ESRD) and determine its metabolic and hemodynamic contributors and clinical outcomes. A total of 74 patients with ESRD (50 men, age 72 ± 11 years) with mild-to-moderate AS were compared with 79 age- and gender-matched controls with normal kidney function. Clinical, laboratory, and echocardiographic features and clinical outcomes including aortic valve (AV) intervention, hospitalization due to heart failure, and cardiovascular death were analyzed. Patients with ESRD were divided into 2 subgroups according to their rate of AV area changes (group 1 [n = 28], rapid progression; and group 2 [n = 46], slow progression). Progression in the degree of AS was noted in 38{\%} of patients with ESRD and 18{\%} of controls (p <0.01) during comparable echocardiographic follow-up durations (29 ± 15 vs 27 ± 24 months, respectively, p = 0.57). In ESRD, patients in group 1 were older (p <0.01) with higher baseline log parathyroid hormone (p <0.01) and larger stroke volume (p = 0.03) than those in group 2. During clinical follow-up (48 ± 23 months), patients in group 1 showed poorer clinical outcomes than those in group 2 and controls (log-rank p <0.01). Age, left atrial volume index ≥42 ml/m2, and annual increases of peak pressure gradient across the AV (mm Hg/year) demonstrated additive predictive values for prognosis. AS in ESRD progresses in an accelerated manner along with higher metabolic and hemodynamic loads on AV compared with those with normal kidney function. Accelerated progression of mild-to-moderate AS in ESRD results in poor prognosis.",
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Effect of End-Stage Renal Disease on Rate of Progression of Aortic Stenosis. / Kim, Darae; Shim, ChiYoung; Hong, Geu Ru; Cho, In Jeong; Chang, Hyuk-Jae; Ha, Jong Won; Chung, Namsik.

In: American Journal of Cardiology, Vol. 117, No. 12, 15.06.2016, p. 1972-1977.

Research output: Contribution to journalArticle

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