Effect of endoscopic sclerotherapy using N-butyl-2-cyanoacrylate in patients with gastric variceal bleeding

Jae Woo Kim, Soonkoo Baik, Kyu Hong Kim, Hye Jeong Kim, Ki Won Jo, Jin Hon Hong, Myeong Gwan Jee, Hyunsoo Kim, Sang Ok Kwon

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

BACKGROUND/AIMS: Gastric variceal bleeding is a severe complication of cirrhosis, and it has a high mortality rate. This study was conducted to evaluate the efficacy of n-butyl-2-cyanoacrylate injection therapy for patients suffering with gastric variceal bleeding. METHODS: A total of 86 patients diagnosed with gastric variceal bleeding underwent endoscopic n-butyl-2-cyanoacrylate (Histoacryl) injection therapy at our department between April, 2002 and July, 2005, with a mean follow-up period of 44 weeks (range: 2 to 136 weeks). The initial hemostasis rate and the rebleeding rate of endoscopic sclerotherapy were analyzed. Also, the cumulative survival rate was analyzed according to the status of hepatocellular carcinoma and hyponatremia, the MELD score, the Child-Pugh score and the amount of injected Histoacryl. RESULTS: The initial hemostasis rate of Histoacryl injection therapy was 93% and the 1 month rebleeding rate was 16.1%. The total number of session for treating the initial hemostasis was 1.2+/-0.4 and the total volume of Histoacryl was 2.7+/-1.2 mL. The cumulative rebleeding-free rates for the patients treated by the Histoacryl injection method at 1 month, 12 months and 34 months period were 95.1%, 83.2% and 74%, respectively. The cumulative survival rates were 78.3% at 1 month, 61.9% at 12 months and 54.6% at 34 months, respectively. No thromboembolic phenomenon occurred. According to the Cox's proportional hazards analysis, only the MELD score (<15) was an independent predicting factor for survival of the patients with gastric variceal bleeding. CONCLUSIONS: Endoscopic sclerotherapy using n-butyl-2-cyanoacrylate was a safe and effective hemostatic method for patients with gastric variceal bleeding. Also, the MELD score (<15) contributed to predicting survival of the patients with gastric variceal bleeding.

Original languageEnglish
Pages (from-to)394-403
Number of pages10
JournalThe Korean journal of hepatology
Volume12
Issue number3
Publication statusPublished - 2006 Jan 1

Fingerprint

Enbucrilate
Sclerotherapy
Stomach
Hemorrhage
Hemostasis
Injections
Survival Rate
Survival
Hyponatremia
Hemostatics
Hepatocellular Carcinoma
Fibrosis
Therapeutics
Mortality

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kim, J. W., Baik, S., Kim, K. H., Kim, H. J., Jo, K. W., Hong, J. H., ... Kwon, S. O. (2006). Effect of endoscopic sclerotherapy using N-butyl-2-cyanoacrylate in patients with gastric variceal bleeding. The Korean journal of hepatology, 12(3), 394-403.
Kim, Jae Woo ; Baik, Soonkoo ; Kim, Kyu Hong ; Kim, Hye Jeong ; Jo, Ki Won ; Hong, Jin Hon ; Jee, Myeong Gwan ; Kim, Hyunsoo ; Kwon, Sang Ok. / Effect of endoscopic sclerotherapy using N-butyl-2-cyanoacrylate in patients with gastric variceal bleeding. In: The Korean journal of hepatology. 2006 ; Vol. 12, No. 3. pp. 394-403.
@article{c4f411cf49c8498189e0242542c294a8,
title = "Effect of endoscopic sclerotherapy using N-butyl-2-cyanoacrylate in patients with gastric variceal bleeding",
abstract = "BACKGROUND/AIMS: Gastric variceal bleeding is a severe complication of cirrhosis, and it has a high mortality rate. This study was conducted to evaluate the efficacy of n-butyl-2-cyanoacrylate injection therapy for patients suffering with gastric variceal bleeding. METHODS: A total of 86 patients diagnosed with gastric variceal bleeding underwent endoscopic n-butyl-2-cyanoacrylate (Histoacryl) injection therapy at our department between April, 2002 and July, 2005, with a mean follow-up period of 44 weeks (range: 2 to 136 weeks). The initial hemostasis rate and the rebleeding rate of endoscopic sclerotherapy were analyzed. Also, the cumulative survival rate was analyzed according to the status of hepatocellular carcinoma and hyponatremia, the MELD score, the Child-Pugh score and the amount of injected Histoacryl. RESULTS: The initial hemostasis rate of Histoacryl injection therapy was 93{\%} and the 1 month rebleeding rate was 16.1{\%}. The total number of session for treating the initial hemostasis was 1.2+/-0.4 and the total volume of Histoacryl was 2.7+/-1.2 mL. The cumulative rebleeding-free rates for the patients treated by the Histoacryl injection method at 1 month, 12 months and 34 months period were 95.1{\%}, 83.2{\%} and 74{\%}, respectively. The cumulative survival rates were 78.3{\%} at 1 month, 61.9{\%} at 12 months and 54.6{\%} at 34 months, respectively. No thromboembolic phenomenon occurred. According to the Cox's proportional hazards analysis, only the MELD score (<15) was an independent predicting factor for survival of the patients with gastric variceal bleeding. CONCLUSIONS: Endoscopic sclerotherapy using n-butyl-2-cyanoacrylate was a safe and effective hemostatic method for patients with gastric variceal bleeding. Also, the MELD score (<15) contributed to predicting survival of the patients with gastric variceal bleeding.",
author = "Kim, {Jae Woo} and Soonkoo Baik and Kim, {Kyu Hong} and Kim, {Hye Jeong} and Jo, {Ki Won} and Hong, {Jin Hon} and Jee, {Myeong Gwan} and Hyunsoo Kim and Kwon, {Sang Ok}",
year = "2006",
month = "1",
day = "1",
language = "English",
volume = "12",
pages = "394--403",
journal = "Clinical and molecular hepatology",
issn = "2287-2728",
publisher = "Korean Association for the Study of the Liver",
number = "3",

}

Kim, JW, Baik, S, Kim, KH, Kim, HJ, Jo, KW, Hong, JH, Jee, MG, Kim, H & Kwon, SO 2006, 'Effect of endoscopic sclerotherapy using N-butyl-2-cyanoacrylate in patients with gastric variceal bleeding', The Korean journal of hepatology, vol. 12, no. 3, pp. 394-403.

Effect of endoscopic sclerotherapy using N-butyl-2-cyanoacrylate in patients with gastric variceal bleeding. / Kim, Jae Woo; Baik, Soonkoo; Kim, Kyu Hong; Kim, Hye Jeong; Jo, Ki Won; Hong, Jin Hon; Jee, Myeong Gwan; Kim, Hyunsoo; Kwon, Sang Ok.

In: The Korean journal of hepatology, Vol. 12, No. 3, 01.01.2006, p. 394-403.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of endoscopic sclerotherapy using N-butyl-2-cyanoacrylate in patients with gastric variceal bleeding

AU - Kim, Jae Woo

AU - Baik, Soonkoo

AU - Kim, Kyu Hong

AU - Kim, Hye Jeong

AU - Jo, Ki Won

AU - Hong, Jin Hon

AU - Jee, Myeong Gwan

AU - Kim, Hyunsoo

AU - Kwon, Sang Ok

PY - 2006/1/1

Y1 - 2006/1/1

N2 - BACKGROUND/AIMS: Gastric variceal bleeding is a severe complication of cirrhosis, and it has a high mortality rate. This study was conducted to evaluate the efficacy of n-butyl-2-cyanoacrylate injection therapy for patients suffering with gastric variceal bleeding. METHODS: A total of 86 patients diagnosed with gastric variceal bleeding underwent endoscopic n-butyl-2-cyanoacrylate (Histoacryl) injection therapy at our department between April, 2002 and July, 2005, with a mean follow-up period of 44 weeks (range: 2 to 136 weeks). The initial hemostasis rate and the rebleeding rate of endoscopic sclerotherapy were analyzed. Also, the cumulative survival rate was analyzed according to the status of hepatocellular carcinoma and hyponatremia, the MELD score, the Child-Pugh score and the amount of injected Histoacryl. RESULTS: The initial hemostasis rate of Histoacryl injection therapy was 93% and the 1 month rebleeding rate was 16.1%. The total number of session for treating the initial hemostasis was 1.2+/-0.4 and the total volume of Histoacryl was 2.7+/-1.2 mL. The cumulative rebleeding-free rates for the patients treated by the Histoacryl injection method at 1 month, 12 months and 34 months period were 95.1%, 83.2% and 74%, respectively. The cumulative survival rates were 78.3% at 1 month, 61.9% at 12 months and 54.6% at 34 months, respectively. No thromboembolic phenomenon occurred. According to the Cox's proportional hazards analysis, only the MELD score (<15) was an independent predicting factor for survival of the patients with gastric variceal bleeding. CONCLUSIONS: Endoscopic sclerotherapy using n-butyl-2-cyanoacrylate was a safe and effective hemostatic method for patients with gastric variceal bleeding. Also, the MELD score (<15) contributed to predicting survival of the patients with gastric variceal bleeding.

AB - BACKGROUND/AIMS: Gastric variceal bleeding is a severe complication of cirrhosis, and it has a high mortality rate. This study was conducted to evaluate the efficacy of n-butyl-2-cyanoacrylate injection therapy for patients suffering with gastric variceal bleeding. METHODS: A total of 86 patients diagnosed with gastric variceal bleeding underwent endoscopic n-butyl-2-cyanoacrylate (Histoacryl) injection therapy at our department between April, 2002 and July, 2005, with a mean follow-up period of 44 weeks (range: 2 to 136 weeks). The initial hemostasis rate and the rebleeding rate of endoscopic sclerotherapy were analyzed. Also, the cumulative survival rate was analyzed according to the status of hepatocellular carcinoma and hyponatremia, the MELD score, the Child-Pugh score and the amount of injected Histoacryl. RESULTS: The initial hemostasis rate of Histoacryl injection therapy was 93% and the 1 month rebleeding rate was 16.1%. The total number of session for treating the initial hemostasis was 1.2+/-0.4 and the total volume of Histoacryl was 2.7+/-1.2 mL. The cumulative rebleeding-free rates for the patients treated by the Histoacryl injection method at 1 month, 12 months and 34 months period were 95.1%, 83.2% and 74%, respectively. The cumulative survival rates were 78.3% at 1 month, 61.9% at 12 months and 54.6% at 34 months, respectively. No thromboembolic phenomenon occurred. According to the Cox's proportional hazards analysis, only the MELD score (<15) was an independent predicting factor for survival of the patients with gastric variceal bleeding. CONCLUSIONS: Endoscopic sclerotherapy using n-butyl-2-cyanoacrylate was a safe and effective hemostatic method for patients with gastric variceal bleeding. Also, the MELD score (<15) contributed to predicting survival of the patients with gastric variceal bleeding.

UR - http://www.scopus.com/inward/record.url?scp=37249002259&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37249002259&partnerID=8YFLogxK

M3 - Article

C2 - 16998291

AN - SCOPUS:37249002259

VL - 12

SP - 394

EP - 403

JO - Clinical and molecular hepatology

JF - Clinical and molecular hepatology

SN - 2287-2728

IS - 3

ER -