Effect of Geometric Remodeling on Left Ventricular Longitudinal Contractile Reserve in Patients with Hypertension

Sungha Park, Hye Sun Seo, Chi Young Shim, Eui Young Choi, Young Guk Ko, Donghoon Choi, Jong Won Ha, Se Joong Rim, Namsik Chung

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Left ventricular hypertrophy (LVH) is associated with a reduction of subendocardial coronary flow reserve, which may be associated with abnormal myocardial longitudinal function during exercise. To test this hypothesis, 182 hypertensive patients underwent multistage supine bicycle exercise testing. Patients were classified as follows: patients with normal geometry (group 1, n = 116), concentric remodeling (group 2, n = 31), or LVH (group 3, n = 31). The results showed that the ratio of E/E', an index of left ventricular (LV) filling pressure, was significantly elevated in the LVH group at rest and during exercise. At rest, the mitral annular systolic velocity (S') was similar between the three groups at rest, whereas S' during exercise was significantly lower in the LVH group. The magnitude of change in S' during exercise was also significantly lower in the LVH group. Multiple linear regression analysis showed that peak double product (β = 0.208, P = .006) and LV mass index (β = -0.158, P = .028) were independently associated with LV longitudinal contractile reserve. Also, multiple linear regression analysis showed that changes in S' from baseline to peak were independently associated with exercise duration (β = 0.123, P = .041) when controlled for age, male gender, baseline E', peak systolic blood pressure, and LV mass index. The results from this study demonstrate that LVH was significantly associated with abnormal LV longitudinal contractile reserve in hypertensive patients.

Original languageEnglish
Pages (from-to)246-250
Number of pages5
JournalJournal of the American Society of Echocardiography
Volume21
Issue number3
DOIs
Publication statusPublished - 2008 Mar

Bibliographical note

Funding Information:
This work was supported by a grant from the Seoul R&BD Program, Republic of Korea (10526). Clinical investigation Ventricular function: Tissue doppler and speckle tracking

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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