Effect of Helicobacter pylori infection on the sonic hedgehog signaling pathway in gastric cancer cells

Jie-Hyun Kim, Yeun Jung Choi, Sang Hun Lee, Hyun Soo Shin, In Ohk Lee, Yu Jin Kim, Hyunki Kim, Woo Ick Yang, Hoguen Kim, Yongchan Lee

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18 Citations (Scopus)

Abstract

This study aimed to investigate the effect of Helicobacter pylori (H. pylori) infection on the sonic Hedgehog (Shh) signaling in gastric cancer. Shh, Patched (Ptch), and transcription factor Gli1 were overexpressed in H. pylori-infected gastric cancer cells. The oncoprotein, CagA positive H. pylori resulted in significantly higher Shh expression. Pretreatment with MG-132 or PDTC significantly lowered Shh expression. Significant overexpression of Shh and Gli1 were noted in H. pylori-infected compared to non-infected gastric cancer tissues. Conclusively, H. pylori activated the Shh signaling pathway in CagA-dependent manner partly through the NF-κB pathway in gastric cancer cells.

Original languageEnglish
Pages (from-to)1523-1528
Number of pages6
JournalOncology Reports
Volume23
Issue number6
DOIs
Publication statusPublished - 2010 Jan 1

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kim, J-H., Choi, Y. J., Lee, S. H., Shin, H. S., Lee, I. O., Kim, Y. J., Kim, H., Yang, W. I., Kim, H., & Lee, Y. (2010). Effect of Helicobacter pylori infection on the sonic hedgehog signaling pathway in gastric cancer cells. Oncology Reports, 23(6), 1523-1528. https://doi.org/10.3892/or-00000791