Abstract
This study aimed to investigate the effect of Helicobacter pylori (H. pylori) infection on the sonic Hedgehog (Shh) signaling in gastric cancer. Shh, Patched (Ptch), and transcription factor Gli1 were overexpressed in H. pylori-infected gastric cancer cells. The oncoprotein, CagA positive H. pylori resulted in significantly higher Shh expression. Pretreatment with MG-132 or PDTC significantly lowered Shh expression. Significant overexpression of Shh and Gli1 were noted in H. pylori-infected compared to non-infected gastric cancer tissues. Conclusively, H. pylori activated the Shh signaling pathway in CagA-dependent manner partly through the NF-κB pathway in gastric cancer cells.
| Original language | English |
|---|---|
| Pages (from-to) | 1523-1528 |
| Number of pages | 6 |
| Journal | Oncology Reports |
| Volume | 23 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2010 Jan 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
Cite this
}
Effect of Helicobacter pylori infection on the sonic hedgehog signaling pathway in gastric cancer cells. / Kim, Jie-Hyun; Choi, Yeun Jung; Lee, Sang Hun; Shin, Hyun Soo; Lee, In Ohk; Kim, Yu Jin; Kim, Hyunki; Yang, Woo Ick; Kim, Hoguen; Lee, Yongchan.
In: Oncology Reports, Vol. 23, No. 6, 01.01.2010, p. 1523-1528.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effect of Helicobacter pylori infection on the sonic hedgehog signaling pathway in gastric cancer cells
AU - Kim, Jie-Hyun
AU - Choi, Yeun Jung
AU - Lee, Sang Hun
AU - Shin, Hyun Soo
AU - Lee, In Ohk
AU - Kim, Yu Jin
AU - Kim, Hyunki
AU - Yang, Woo Ick
AU - Kim, Hoguen
AU - Lee, Yongchan
PY - 2010/1/1
Y1 - 2010/1/1
N2 - This study aimed to investigate the effect of Helicobacter pylori (H. pylori) infection on the sonic Hedgehog (Shh) signaling in gastric cancer. Shh, Patched (Ptch), and transcription factor Gli1 were overexpressed in H. pylori-infected gastric cancer cells. The oncoprotein, CagA positive H. pylori resulted in significantly higher Shh expression. Pretreatment with MG-132 or PDTC significantly lowered Shh expression. Significant overexpression of Shh and Gli1 were noted in H. pylori-infected compared to non-infected gastric cancer tissues. Conclusively, H. pylori activated the Shh signaling pathway in CagA-dependent manner partly through the NF-κB pathway in gastric cancer cells.
AB - This study aimed to investigate the effect of Helicobacter pylori (H. pylori) infection on the sonic Hedgehog (Shh) signaling in gastric cancer. Shh, Patched (Ptch), and transcription factor Gli1 were overexpressed in H. pylori-infected gastric cancer cells. The oncoprotein, CagA positive H. pylori resulted in significantly higher Shh expression. Pretreatment with MG-132 or PDTC significantly lowered Shh expression. Significant overexpression of Shh and Gli1 were noted in H. pylori-infected compared to non-infected gastric cancer tissues. Conclusively, H. pylori activated the Shh signaling pathway in CagA-dependent manner partly through the NF-κB pathway in gastric cancer cells.
UR - http://www.scopus.com/inward/record.url?scp=77951749929&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951749929&partnerID=8YFLogxK
U2 - 10.3892/or-00000791
DO - 10.3892/or-00000791
M3 - Article
C2 - 20428805
AN - SCOPUS:77951749929
VL - 23
SP - 1523
EP - 1528
JO - Oncology Reports
JF - Oncology Reports
SN - 1021-335X
IS - 6
ER -