Abstract
This study aimed to investigate the effect of Helicobacter pylori (H. pylori) infection on the sonic Hedgehog (Shh) signaling in gastric cancer. Shh, Patched (Ptch), and transcription factor Gli1 were overexpressed in H. pylori-infected gastric cancer cells. The oncoprotein, CagA positive H. pylori resulted in significantly higher Shh expression. Pretreatment with MG-132 or PDTC significantly lowered Shh expression. Significant overexpression of Shh and Gli1 were noted in H. pylori-infected compared to non-infected gastric cancer tissues. Conclusively, H. pylori activated the Shh signaling pathway in CagA-dependent manner partly through the NF-κB pathway in gastric cancer cells.
| Original language | English |
|---|---|
| Pages (from-to) | 1523-1528 |
| Number of pages | 6 |
| Journal | Oncology reports |
| Volume | 23 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2010 Jun |
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
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Cite this
Kim, J. H., Choi, Y. J., Lee, S. H., Shin, H. S., Lee, I. O., Kim, Y. J., Kim, H., Yang, W. I., Kim, H., & Lee, Y. C. (2010). Effect of Helicobacter pylori infection on the sonic hedgehog signaling pathway in gastric cancer cells. Oncology reports, 23(6), 1523-1528. https://doi.org/10.3892/or-00000791