Abstract
Purpose Diuretics are used frequently in critically ill patients. We investigated the effects of furosemide on the prognosis. Materials and methods Following a retrospective review of patients admitted to the medical intensive care unit (ICU), we analyzed risk factors with variables including initial furosemide dose for ICU mortality. Results A total of 448 patients were included. Total furosemide dose during the first three days of the ICU stay (odds ratio (OR) 2.35, 95% confidence interval (CI) 1.01–5.02) and fluid balance during the same period (OR 3.04, 95% CI 1.46–6.31) were associated with ICU mortality, as were malignancy, chronic furosemide use, and APACHE II score. However, in oliguric patients, positive fluid balance was associated with ICU mortality (OR 22.33, 95% CI 1.82–273.72) but the high-dose furosemide was not. In contrast, in non-oliguric patients, high-dose furosemide was associated with ICU mortality (OR 2.47, 95% CI 1.01–5.68); however, the positive fluid balance showed only a trend for high ICU mortality. Conclusion Early high-dose furosemide use is associated with ICU mortality, particularly in non-oliguric patients. We suggest that furosemide should be used with caution even in non-oliguric critically ill patients until the safety is confirmed in powered study.
| Original language | English |
|---|---|
| Pages (from-to) | 36-41 |
| Number of pages | 6 |
| Journal | Journal of Critical Care |
| Volume | 41 |
| DOIs | |
| Publication status | Published - 2017 Oct 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Critical Care and Intensive Care Medicine
Cite this
}
Effect of high-dose furosemide on the prognosis of critically ill patients. / Lee, Seok Jeong; Kim, Chong Whan; Lee, Myoung Kyu; Kim, Sangha; Yong, Suk Joong; Lee, Won Yeon.
In: Journal of Critical Care, Vol. 41, 01.10.2017, p. 36-41.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effect of high-dose furosemide on the prognosis of critically ill patients
AU - Lee, Seok Jeong
AU - Kim, Chong Whan
AU - Lee, Myoung Kyu
AU - Kim, Sangha
AU - Yong, Suk Joong
AU - Lee, Won Yeon
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Purpose Diuretics are used frequently in critically ill patients. We investigated the effects of furosemide on the prognosis. Materials and methods Following a retrospective review of patients admitted to the medical intensive care unit (ICU), we analyzed risk factors with variables including initial furosemide dose for ICU mortality. Results A total of 448 patients were included. Total furosemide dose during the first three days of the ICU stay (odds ratio (OR) 2.35, 95% confidence interval (CI) 1.01–5.02) and fluid balance during the same period (OR 3.04, 95% CI 1.46–6.31) were associated with ICU mortality, as were malignancy, chronic furosemide use, and APACHE II score. However, in oliguric patients, positive fluid balance was associated with ICU mortality (OR 22.33, 95% CI 1.82–273.72) but the high-dose furosemide was not. In contrast, in non-oliguric patients, high-dose furosemide was associated with ICU mortality (OR 2.47, 95% CI 1.01–5.68); however, the positive fluid balance showed only a trend for high ICU mortality. Conclusion Early high-dose furosemide use is associated with ICU mortality, particularly in non-oliguric patients. We suggest that furosemide should be used with caution even in non-oliguric critically ill patients until the safety is confirmed in powered study.
AB - Purpose Diuretics are used frequently in critically ill patients. We investigated the effects of furosemide on the prognosis. Materials and methods Following a retrospective review of patients admitted to the medical intensive care unit (ICU), we analyzed risk factors with variables including initial furosemide dose for ICU mortality. Results A total of 448 patients were included. Total furosemide dose during the first three days of the ICU stay (odds ratio (OR) 2.35, 95% confidence interval (CI) 1.01–5.02) and fluid balance during the same period (OR 3.04, 95% CI 1.46–6.31) were associated with ICU mortality, as were malignancy, chronic furosemide use, and APACHE II score. However, in oliguric patients, positive fluid balance was associated with ICU mortality (OR 22.33, 95% CI 1.82–273.72) but the high-dose furosemide was not. In contrast, in non-oliguric patients, high-dose furosemide was associated with ICU mortality (OR 2.47, 95% CI 1.01–5.68); however, the positive fluid balance showed only a trend for high ICU mortality. Conclusion Early high-dose furosemide use is associated with ICU mortality, particularly in non-oliguric patients. We suggest that furosemide should be used with caution even in non-oliguric critically ill patients until the safety is confirmed in powered study.
UR - http://www.scopus.com/inward/record.url?scp=85020730942&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020730942&partnerID=8YFLogxK
U2 - 10.1016/j.jcrc.2017.04.045
DO - 10.1016/j.jcrc.2017.04.045
M3 - Article
C2 - 28477508
AN - SCOPUS:85020730942
VL - 41
SP - 36
EP - 41
JO - Journal of Critical Care
JF - Journal of Critical Care
SN - 0883-9441
ER -