Effect of home-based exercise intervention on fasting insulin and Adipocytokines in colorectal cancer survivors: a randomized controlled trial

Mi Kyung Lee, Ji Young Kim, Dong Il Kim, Dong Woo Kang, Ji hye Park, Ki Yong Ahn, Hyuk In Yang, Dong Hoon Lee, Yun Ho Roh, Ji Won Lee, Sang Hui Chu, Jeffrey A. Meyerhardt, Lee W. Jones, Nam Kyu Kim, Justin Y. Jeon

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background and Aims Elevated circulating insulin is associated with increased risk of recurrence and cancer mortality in early-stage colorectal cancer (CRC). We conducted a randomized controlled trial to determine the effect of a 12-week home-based exercise program on fasting insulin, adipocytokines, and physical function in CRC survivors. Methods One hundred and twenty-three stage II-III CRC patients were randomly assigned to either a home-based exercise (n = 62) or standard care control group (n = 61) for 12 weeks. Home-based exercise consisted of aerobic and resistance training, with a goal of obtaining ≥ 18 metabolic equivalent task (MET)-h/wk. Participants in the exercise group were instructed to participate in > 18 MET-h/wk. of aerobic and resistance exercise while the participants in the control group were asked to maintain their usual daily activity. The primary outcome was fasting insulin levels. Secondary outcomes were adiponectin, TNF-α levels and 6 min walk distance from baseline to post-intervention. Results After the 12-weeks, moderate-vigorous physical activity participation increased from 9.1 ± 14.7 MET-h/wk. to 26.6 ± 21.7 MET-h/wk. in the exercise group, with no change in the control group (p < 0.01 for group and time interaction). Circulating insulin level decreased by 1 μU/ml (6.0 ± 3.9 vs. 5.0 ± 3.5, p = 0.009) in the exercise group with no change in the control group (p = 0.022 for group and time interaction). A similar trend was observed in TNF-α (p = 0.030 for group and time interaction). Six minute walk distance increased by 25.2 m in the exercise group with no change in the control group (p = 0.061 for group and time interaction). Conclusions The 12 week home-based exercise program increased level of physical activity and decreased circulating insulin levels in CRC survivors.

Original languageEnglish
Pages (from-to)23-31
Number of pages9
JournalMetabolism: Clinical and Experimental
Volume76
DOIs
Publication statusPublished - 2017 Nov

Fingerprint

Adipokines
Survivors
Colorectal Neoplasms
Fasting
Randomized Controlled Trials
Exercise
Insulin
Metabolic Equivalent
Control Groups
Resistance Training
Adiponectin
Recurrence

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Lee, Mi Kyung ; Kim, Ji Young ; Kim, Dong Il ; Kang, Dong Woo ; Park, Ji hye ; Ahn, Ki Yong ; In Yang, Hyuk ; Lee, Dong Hoon ; Roh, Yun Ho ; Lee, Ji Won ; Chu, Sang Hui ; Meyerhardt, Jeffrey A. ; Jones, Lee W. ; Kim, Nam Kyu ; Jeon, Justin Y. / Effect of home-based exercise intervention on fasting insulin and Adipocytokines in colorectal cancer survivors : a randomized controlled trial. In: Metabolism: Clinical and Experimental. 2017 ; Vol. 76. pp. 23-31.
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title = "Effect of home-based exercise intervention on fasting insulin and Adipocytokines in colorectal cancer survivors: a randomized controlled trial",
abstract = "Background and Aims Elevated circulating insulin is associated with increased risk of recurrence and cancer mortality in early-stage colorectal cancer (CRC). We conducted a randomized controlled trial to determine the effect of a 12-week home-based exercise program on fasting insulin, adipocytokines, and physical function in CRC survivors. Methods One hundred and twenty-three stage II-III CRC patients were randomly assigned to either a home-based exercise (n = 62) or standard care control group (n = 61) for 12 weeks. Home-based exercise consisted of aerobic and resistance training, with a goal of obtaining ≥ 18 metabolic equivalent task (MET)-h/wk. Participants in the exercise group were instructed to participate in > 18 MET-h/wk. of aerobic and resistance exercise while the participants in the control group were asked to maintain their usual daily activity. The primary outcome was fasting insulin levels. Secondary outcomes were adiponectin, TNF-α levels and 6 min walk distance from baseline to post-intervention. Results After the 12-weeks, moderate-vigorous physical activity participation increased from 9.1 ± 14.7 MET-h/wk. to 26.6 ± 21.7 MET-h/wk. in the exercise group, with no change in the control group (p < 0.01 for group and time interaction). Circulating insulin level decreased by 1 μU/ml (6.0 ± 3.9 vs. 5.0 ± 3.5, p = 0.009) in the exercise group with no change in the control group (p = 0.022 for group and time interaction). A similar trend was observed in TNF-α (p = 0.030 for group and time interaction). Six minute walk distance increased by 25.2 m in the exercise group with no change in the control group (p = 0.061 for group and time interaction). Conclusions The 12 week home-based exercise program increased level of physical activity and decreased circulating insulin levels in CRC survivors.",
author = "Lee, {Mi Kyung} and Kim, {Ji Young} and Kim, {Dong Il} and Kang, {Dong Woo} and Park, {Ji hye} and Ahn, {Ki Yong} and {In Yang}, Hyuk and Lee, {Dong Hoon} and Roh, {Yun Ho} and Lee, {Ji Won} and Chu, {Sang Hui} and Meyerhardt, {Jeffrey A.} and Jones, {Lee W.} and Kim, {Nam Kyu} and Jeon, {Justin Y.}",
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Effect of home-based exercise intervention on fasting insulin and Adipocytokines in colorectal cancer survivors : a randomized controlled trial. / Lee, Mi Kyung; Kim, Ji Young; Kim, Dong Il; Kang, Dong Woo; Park, Ji hye; Ahn, Ki Yong; In Yang, Hyuk; Lee, Dong Hoon; Roh, Yun Ho; Lee, Ji Won; Chu, Sang Hui; Meyerhardt, Jeffrey A.; Jones, Lee W.; Kim, Nam Kyu; Jeon, Justin Y.

In: Metabolism: Clinical and Experimental, Vol. 76, 11.2017, p. 23-31.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of home-based exercise intervention on fasting insulin and Adipocytokines in colorectal cancer survivors

T2 - a randomized controlled trial

AU - Lee, Mi Kyung

AU - Kim, Ji Young

AU - Kim, Dong Il

AU - Kang, Dong Woo

AU - Park, Ji hye

AU - Ahn, Ki Yong

AU - In Yang, Hyuk

AU - Lee, Dong Hoon

AU - Roh, Yun Ho

AU - Lee, Ji Won

AU - Chu, Sang Hui

AU - Meyerhardt, Jeffrey A.

AU - Jones, Lee W.

AU - Kim, Nam Kyu

AU - Jeon, Justin Y.

PY - 2017/11

Y1 - 2017/11

N2 - Background and Aims Elevated circulating insulin is associated with increased risk of recurrence and cancer mortality in early-stage colorectal cancer (CRC). We conducted a randomized controlled trial to determine the effect of a 12-week home-based exercise program on fasting insulin, adipocytokines, and physical function in CRC survivors. Methods One hundred and twenty-three stage II-III CRC patients were randomly assigned to either a home-based exercise (n = 62) or standard care control group (n = 61) for 12 weeks. Home-based exercise consisted of aerobic and resistance training, with a goal of obtaining ≥ 18 metabolic equivalent task (MET)-h/wk. Participants in the exercise group were instructed to participate in > 18 MET-h/wk. of aerobic and resistance exercise while the participants in the control group were asked to maintain their usual daily activity. The primary outcome was fasting insulin levels. Secondary outcomes were adiponectin, TNF-α levels and 6 min walk distance from baseline to post-intervention. Results After the 12-weeks, moderate-vigorous physical activity participation increased from 9.1 ± 14.7 MET-h/wk. to 26.6 ± 21.7 MET-h/wk. in the exercise group, with no change in the control group (p < 0.01 for group and time interaction). Circulating insulin level decreased by 1 μU/ml (6.0 ± 3.9 vs. 5.0 ± 3.5, p = 0.009) in the exercise group with no change in the control group (p = 0.022 for group and time interaction). A similar trend was observed in TNF-α (p = 0.030 for group and time interaction). Six minute walk distance increased by 25.2 m in the exercise group with no change in the control group (p = 0.061 for group and time interaction). Conclusions The 12 week home-based exercise program increased level of physical activity and decreased circulating insulin levels in CRC survivors.

AB - Background and Aims Elevated circulating insulin is associated with increased risk of recurrence and cancer mortality in early-stage colorectal cancer (CRC). We conducted a randomized controlled trial to determine the effect of a 12-week home-based exercise program on fasting insulin, adipocytokines, and physical function in CRC survivors. Methods One hundred and twenty-three stage II-III CRC patients were randomly assigned to either a home-based exercise (n = 62) or standard care control group (n = 61) for 12 weeks. Home-based exercise consisted of aerobic and resistance training, with a goal of obtaining ≥ 18 metabolic equivalent task (MET)-h/wk. Participants in the exercise group were instructed to participate in > 18 MET-h/wk. of aerobic and resistance exercise while the participants in the control group were asked to maintain their usual daily activity. The primary outcome was fasting insulin levels. Secondary outcomes were adiponectin, TNF-α levels and 6 min walk distance from baseline to post-intervention. Results After the 12-weeks, moderate-vigorous physical activity participation increased from 9.1 ± 14.7 MET-h/wk. to 26.6 ± 21.7 MET-h/wk. in the exercise group, with no change in the control group (p < 0.01 for group and time interaction). Circulating insulin level decreased by 1 μU/ml (6.0 ± 3.9 vs. 5.0 ± 3.5, p = 0.009) in the exercise group with no change in the control group (p = 0.022 for group and time interaction). A similar trend was observed in TNF-α (p = 0.030 for group and time interaction). Six minute walk distance increased by 25.2 m in the exercise group with no change in the control group (p = 0.061 for group and time interaction). Conclusions The 12 week home-based exercise program increased level of physical activity and decreased circulating insulin levels in CRC survivors.

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