Effect of IL-4 on the development and function of memory-like CD8 T cells in the peripheral lymphoid tissues

Hi Jung Park, Ara Lee, Jae Il Lee, Seong Hoe Park, Sang Jun Ha, Kyeong Cheon Jung

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Unlike conventional T cells, innate CD8 T cells develop a memory-like phenotype in the thymus and immediately respond upon antigen stimulation, similar to memory T cells. The development of innate CD8 T cells in the thymus is known to require IL-4, which upregulates Eomesodermin (Eomes). These features are similar to that of virtual memory CD8 T cells and IL-4-induced memory-like CD8 T cells generated in the peripheral tissues. However, the relationship between these cell types has not been clearly documented. In the present study, IL-4-induced memory-like CD8 T cells generated in the peripheral tissues were compared with innate CD8 T cells in terms of phenotype and function. When an IL-4/anti-IL-4 antibody complex (IL-4C) was injected into C57BL/6 mice daily for 7 days, the EomeshiCXCR3 CD8 T cell population was markedly increased in the peripheral lymphoid organs and blood. These cells were generated from naïve CD8 T cells or accumulated via the expansion of pre-existing CD44hiCXCR3 CD8 T cells. Initially, the majority of these CXCR3 CD8 T cells expressed low levels of CD44, which was followed by the conversion to the CD44hi phenotype. This conversion was associated with the acquisition of enhanced ef- fector function. After discontinuation of IL-4C treatment, Eomes expression levels gradually decreased in CXCR3 CD8 T cells. Taken together, the results of this study demonstrate that IL-4-induced memory-like CD8 T cells generated in the peripheral lymphoid tissues are phenotypi-cally and functionally similar to the innate CD8 T cells generated in the thymus.

Original languageEnglish
Pages (from-to)126-133
Number of pages8
JournalImmune Network
Volume16
Issue number2
DOIs
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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