BACKGROUND/OBJECTIVES: Enteral nutrition formulas with immune-enhancing nutrients, such as n-3 fatty acids, may manage patients’ nutritional status and pathophysiological processes. The aim of our study was to investigate natural killer (NK) cell activity alterations and related cytokine changes resulting from feeding with soybean oil-containing enteral nutrition formula (control group) and plant-derived n-3 fatty acid-enriched enteral nutrition formula. SUBJECTS/METHODS: Subjects participated for 14 consecutive days and consumed enteral formula containing canola and flaxseed oil (n3EN, test group) in nonsurgical patients hospitalized for rehabilitation. Blood samples were collected on the first day and 14 days after the consumption of each formula daily, and anthropometric parameters were collected. Hematology and biochemical values were analyzed, and NK cell activities and serum cytokine concentration were measured. A total of sixty subjects were included in the analysis, excluding dropouts. RESULTS: No significant differences were found in biochemical parameters. The n3EN group’s NK cell activities at effector:tumor cell ratios of 10:1, 5:1, 2.5:1 and 0.625:1 were significantly higher than those of the control group after two weeks (P < 0.05). However, there were no statistically significant differences in serum cytokine interleukin (IL)-12, interferon-γ, IL-1β, IL-6 and tumor necrosis factor-α values between the two groups. CONCLUSIONS: In conclusion, this study elucidates the beneficial effects of plant-derived n-3 fatty acid supplementation in enteral formula on NK cell activity.
Bibliographical noteFunding Information:
This work was supported by Yonsei Dairy Co., Seoul, Republic of Korea. We appreciate Mr. Dong Hoon Chang and Mr. Sang Won Kim who belongs to the Yonsei Dairy Central Research Lab, Asan-si, Chungcheongnam-do, Seoul, Korea, for providing research materials.
This work was supported by Yonsei Dairy Co., Seoul, Republic of Korea (2015-11-0448). §Corresponding Authors: Jong Ho Lee, Tel. 82-2-2123-3122, Fax. 82-2-364-9605, Email. email@example.com Deog Young Kim, Tel. 82-222-283-714, Fax. 82-2363-2795, Email. firstname.lastname@example.org Received: January 24, 2019, Revised: April 24, 2019, Accepted: June 17, 2019 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
This work was supported by Yonsei Dairy Co., Seoul, Republic of Korea (2015-11-0448). We appreciate Mr. Dong Hoon Chang and Mr. Sang Won Kim who belongs to the Yonsei Dairy Central Research Lab, Asan-si, Chungcheongnam-do, Seoul, Korea, for providing research materials.
All Science Journal Classification (ASJC) codes
- Food Science
- Nutrition and Dietetics