Effect of ionizing radiation on rat tissue

Proteomic and biochemical analysis

Eui Chul Park, Jong-Bok Yoon, Jinsil Seong, Kyoung Soo Choi, Eung Sik Kong, Yun Jeong Kim, Young Mee Park, Eun Mi Park

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Reactive oxygen species (ROS), generated by ionizing radiation, has been implicated in its effect on living tissues. We confirmed the changes in the oxidative stress markers upon irradiation. We characterized the changes in the proteome profile in rat liver after administering irradiation, and the affected proteins were identified by MALDI-TOF-MS and ESI-MS/MS. The identified proteins represent diverse sets of proteins participating in the cellular metabolism. Our results demonstrated that proteomics analysis is a useful method for characterization of a global proteome change caused by ionizing radiation to unravel the molecular mechanisms involved in the cellular responses to ionizing radiation.

Original languageEnglish
Pages (from-to)19-35
Number of pages17
JournalPreparative Biochemistry and Biotechnology
Volume36
Issue number1
DOIs
Publication statusPublished - 2006 Feb 1

Fingerprint

Ionizing radiation
Ionizing Radiation
Proteomics
Rats
Proteome
Tissue
Irradiation
Proteins
Oxidative stress
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Metabolism
Liver
Reactive Oxygen Species
Oxidative Stress

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry

Cite this

Park, Eui Chul ; Yoon, Jong-Bok ; Seong, Jinsil ; Choi, Kyoung Soo ; Kong, Eung Sik ; Kim, Yun Jeong ; Park, Young Mee ; Park, Eun Mi. / Effect of ionizing radiation on rat tissue : Proteomic and biochemical analysis. In: Preparative Biochemistry and Biotechnology. 2006 ; Vol. 36, No. 1. pp. 19-35.
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Effect of ionizing radiation on rat tissue : Proteomic and biochemical analysis. / Park, Eui Chul; Yoon, Jong-Bok; Seong, Jinsil; Choi, Kyoung Soo; Kong, Eung Sik; Kim, Yun Jeong; Park, Young Mee; Park, Eun Mi.

In: Preparative Biochemistry and Biotechnology, Vol. 36, No. 1, 01.02.2006, p. 19-35.

Research output: Contribution to journalArticle

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