Effect of IOP elevation on matrix metalloproteinase-2 in rabbit anterior chamber.

chanyun kim, S. S. Kim, H. J. Koh, Y. S. You, G. J. Seong, Y. J. Hong

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To investigate changes in the level of matrix metalloproteinase-2 (MMP-2) in the anterior chamber of rabbit with intraocular pressure (IOP) elevation. The IOP was elevated with scleral encircling in 12 rabbits. In the control group (4 rabbits), IOP was not changed after scleral encircling, and in group 1 (4 rabbits) and 2 (4 rabbits), IOP was elevated about 10 and 20 mmHg respectively after scleral encircling. At 2 days after scleral encircling, aqueous sampling was performed and levels of MMP-2 were checked by Western blots and gelatin zymograms. The greater the IOP elevation, the more MMP-2 expression in the anterior chamber by Western blots and gelatin zymograms. The increase in MMP-2 expression in response to IOP elevation may have important implications for the IOP feedback control mechanism.

Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalKorean journal of ophthalmology : KJO
Volume14
Issue number1
DOIs
Publication statusPublished - 2000 Jan 1

Fingerprint

Matrix Metalloproteinase 2
Anterior Chamber
Intraocular Pressure
Rabbits
Gelatin
Western Blotting
Control Groups

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

kim, chanyun ; Kim, S. S. ; Koh, H. J. ; You, Y. S. ; Seong, G. J. ; Hong, Y. J. / Effect of IOP elevation on matrix metalloproteinase-2 in rabbit anterior chamber. In: Korean journal of ophthalmology : KJO. 2000 ; Vol. 14, No. 1. pp. 27-31.
@article{5c19222cfd2e48edac7831e7c472b06b,
title = "Effect of IOP elevation on matrix metalloproteinase-2 in rabbit anterior chamber.",
abstract = "To investigate changes in the level of matrix metalloproteinase-2 (MMP-2) in the anterior chamber of rabbit with intraocular pressure (IOP) elevation. The IOP was elevated with scleral encircling in 12 rabbits. In the control group (4 rabbits), IOP was not changed after scleral encircling, and in group 1 (4 rabbits) and 2 (4 rabbits), IOP was elevated about 10 and 20 mmHg respectively after scleral encircling. At 2 days after scleral encircling, aqueous sampling was performed and levels of MMP-2 were checked by Western blots and gelatin zymograms. The greater the IOP elevation, the more MMP-2 expression in the anterior chamber by Western blots and gelatin zymograms. The increase in MMP-2 expression in response to IOP elevation may have important implications for the IOP feedback control mechanism.",
author = "chanyun kim and Kim, {S. S.} and Koh, {H. J.} and You, {Y. S.} and Seong, {G. J.} and Hong, {Y. J.}",
year = "2000",
month = "1",
day = "1",
doi = "10.3341/kjo.2000.14.1.27",
language = "English",
volume = "14",
pages = "27--31",
journal = "Korean journal of ophthalmology : KJO",
issn = "1011-8942",
publisher = "Seoul Kjo",
number = "1",

}

Effect of IOP elevation on matrix metalloproteinase-2 in rabbit anterior chamber. / kim, chanyun; Kim, S. S.; Koh, H. J.; You, Y. S.; Seong, G. J.; Hong, Y. J.

In: Korean journal of ophthalmology : KJO, Vol. 14, No. 1, 01.01.2000, p. 27-31.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of IOP elevation on matrix metalloproteinase-2 in rabbit anterior chamber.

AU - kim, chanyun

AU - Kim, S. S.

AU - Koh, H. J.

AU - You, Y. S.

AU - Seong, G. J.

AU - Hong, Y. J.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - To investigate changes in the level of matrix metalloproteinase-2 (MMP-2) in the anterior chamber of rabbit with intraocular pressure (IOP) elevation. The IOP was elevated with scleral encircling in 12 rabbits. In the control group (4 rabbits), IOP was not changed after scleral encircling, and in group 1 (4 rabbits) and 2 (4 rabbits), IOP was elevated about 10 and 20 mmHg respectively after scleral encircling. At 2 days after scleral encircling, aqueous sampling was performed and levels of MMP-2 were checked by Western blots and gelatin zymograms. The greater the IOP elevation, the more MMP-2 expression in the anterior chamber by Western blots and gelatin zymograms. The increase in MMP-2 expression in response to IOP elevation may have important implications for the IOP feedback control mechanism.

AB - To investigate changes in the level of matrix metalloproteinase-2 (MMP-2) in the anterior chamber of rabbit with intraocular pressure (IOP) elevation. The IOP was elevated with scleral encircling in 12 rabbits. In the control group (4 rabbits), IOP was not changed after scleral encircling, and in group 1 (4 rabbits) and 2 (4 rabbits), IOP was elevated about 10 and 20 mmHg respectively after scleral encircling. At 2 days after scleral encircling, aqueous sampling was performed and levels of MMP-2 were checked by Western blots and gelatin zymograms. The greater the IOP elevation, the more MMP-2 expression in the anterior chamber by Western blots and gelatin zymograms. The increase in MMP-2 expression in response to IOP elevation may have important implications for the IOP feedback control mechanism.

UR - http://www.scopus.com/inward/record.url?scp=0034201258&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034201258&partnerID=8YFLogxK

U2 - 10.3341/kjo.2000.14.1.27

DO - 10.3341/kjo.2000.14.1.27

M3 - Article

VL - 14

SP - 27

EP - 31

JO - Korean journal of ophthalmology : KJO

JF - Korean journal of ophthalmology : KJO

SN - 1011-8942

IS - 1

ER -