Effect of ipsilateral subthalamic nucleus lesioning in a rat parkinsonian model: Study of behavior correlated with neuronal activity in the pedunculopontine nucleus

Mi Fa Jeon, Yoon Ha, Yoon Hee Cho, Bae Hwan Lee, Yong Gou Park, JinWoo Chang

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Object. The purpose of this study was to investigate the spontaneous behavioral changes and the alteration of neuronal activities in the pedunculopontine nucleus (PPN) after ipsilateral subthalamic nucleus (STN) lesioning by kainic acid in a rat parkinsonian model created by lesioning with 6-hydroxydopamine (6-OHDA). Methods. Assumptions about the mechanisms mediating the effects of lesioning of the nigrostriatal dopaminergic pathway by 6-OHDA and the effects of STN lesioning were examined behaviorally by means of apomorphine-induced rotational behavior and forepaw-adjusting steps. The authors subsequently investigated the alteration of neuronal activities in the PPN to compare them with the behavioral changes in rat parkinsonian models. Conclusions. The results demonstrated that STN lesioning induced behavioral improvement in rat parkinsonian models. This result, which confirms previously held assumptions, may account for the therapeutic effect of STN stimulation in Parkinson disease. The alteration of the neuronal activities in the PPN units also indicates that the PPN units are responsible for the improvement in motor symptoms observed after STN lesioning in rat parkinsonian models.

Original languageEnglish
Pages (from-to)762-767
Number of pages6
JournalJournal of neurosurgery
Volume99
Issue number4
DOIs
Publication statusPublished - 2003 Oct 1

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Subthalamic Nucleus
Oxidopamine
Apomorphine
Kainic Acid
Therapeutic Uses
Parkinson Disease

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

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title = "Effect of ipsilateral subthalamic nucleus lesioning in a rat parkinsonian model: Study of behavior correlated with neuronal activity in the pedunculopontine nucleus",
abstract = "Object. The purpose of this study was to investigate the spontaneous behavioral changes and the alteration of neuronal activities in the pedunculopontine nucleus (PPN) after ipsilateral subthalamic nucleus (STN) lesioning by kainic acid in a rat parkinsonian model created by lesioning with 6-hydroxydopamine (6-OHDA). Methods. Assumptions about the mechanisms mediating the effects of lesioning of the nigrostriatal dopaminergic pathway by 6-OHDA and the effects of STN lesioning were examined behaviorally by means of apomorphine-induced rotational behavior and forepaw-adjusting steps. The authors subsequently investigated the alteration of neuronal activities in the PPN to compare them with the behavioral changes in rat parkinsonian models. Conclusions. The results demonstrated that STN lesioning induced behavioral improvement in rat parkinsonian models. This result, which confirms previously held assumptions, may account for the therapeutic effect of STN stimulation in Parkinson disease. The alteration of the neuronal activities in the PPN units also indicates that the PPN units are responsible for the improvement in motor symptoms observed after STN lesioning in rat parkinsonian models.",
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Effect of ipsilateral subthalamic nucleus lesioning in a rat parkinsonian model : Study of behavior correlated with neuronal activity in the pedunculopontine nucleus. / Jeon, Mi Fa; Ha, Yoon; Cho, Yoon Hee; Lee, Bae Hwan; Park, Yong Gou; Chang, JinWoo.

In: Journal of neurosurgery, Vol. 99, No. 4, 01.10.2003, p. 762-767.

Research output: Contribution to journalArticle

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AU - Chang, JinWoo

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