Effect of ligand structure on MnO nanoparticles for enhanced T1 magnetic resonance imaging of inflammatory macrophages

Joseph Park, Doyeon Bang, Eunjung Kim, Jaemoon Yang, Eun Kyung Lim, Jihye Choi, Byunghoon Kang, Jin Suck Suh, Hyo Seon Park, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Carboxymethyl-dextran (CM-dextran) replaced the hydrophobic oleylamine ligands on the surfaces of MnO nanoparticles, rendering them highly water-soluble by allowing direct contact with excited water protons. Solution MRI studies of the two types of nanoparticles, exchanged and bilayered, with different core sizes have shown that the exchanged ligand structure exhibits significantly enhanced longitudinal relaxation. The modification with dextran converted the nanoparticles into effective T1 MRI contrast agents, as well as promoting strong interactions with macrophages. Thus, it is a potential MR contrast agent for visualizing inflammatory macrophages. Carboxymethyl-dextran can replace the hydrophobic oleylamine ligands on the surfaces of MnO nanoparticles, rendering them highly water-soluble by allowing direct contact with excited water protons. The modification to the dextran converts the nanoparticles into effective T1 MRI contrast agents, as well as promoting strong interactions with macrophages.

Original languageEnglish
Pages (from-to)5960-5965
Number of pages6
JournalEuropean Journal of Inorganic Chemistry
Issue number36
DOIs
Publication statusPublished - 2012 Dec

All Science Journal Classification (ASJC) codes

  • Inorganic Chemistry

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