Abstract
Carboxymethyl-dextran (CM-dextran) replaced the hydrophobic oleylamine ligands on the surfaces of MnO nanoparticles, rendering them highly water-soluble by allowing direct contact with excited water protons. Solution MRI studies of the two types of nanoparticles, exchanged and bilayered, with different core sizes have shown that the exchanged ligand structure exhibits significantly enhanced longitudinal relaxation. The modification with dextran converted the nanoparticles into effective T1 MRI contrast agents, as well as promoting strong interactions with macrophages. Thus, it is a potential MR contrast agent for visualizing inflammatory macrophages. Carboxymethyl-dextran can replace the hydrophobic oleylamine ligands on the surfaces of MnO nanoparticles, rendering them highly water-soluble by allowing direct contact with excited water protons. The modification to the dextran converts the nanoparticles into effective T1 MRI contrast agents, as well as promoting strong interactions with macrophages.
| Original language | English |
|---|---|
| Pages (from-to) | 5960-5965 |
| Number of pages | 6 |
| Journal | European Journal of Inorganic Chemistry |
| Issue number | 36 |
| DOIs | |
| Publication status | Published - 2012 Dec 1 |
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All Science Journal Classification (ASJC) codes
- Inorganic Chemistry
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Effect of ligand structure on MnO nanoparticles for enhanced T1 magnetic resonance imaging of inflammatory macrophages. / Park, Joseph; Bang, Doyeon; Kim, Eunjung; Yang, Jaemoon; Lim, Eun Kyung; Choi, Jihye; Kang, Byunghoon; Suh, Jin Suck; Park, Hyo Seon; Huh, Yong Min; Haam, Seungjoo.
In: European Journal of Inorganic Chemistry, No. 36, 01.12.2012, p. 5960-5965.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effect of ligand structure on MnO nanoparticles for enhanced T1 magnetic resonance imaging of inflammatory macrophages
AU - Park, Joseph
AU - Bang, Doyeon
AU - Kim, Eunjung
AU - Yang, Jaemoon
AU - Lim, Eun Kyung
AU - Choi, Jihye
AU - Kang, Byunghoon
AU - Suh, Jin Suck
AU - Park, Hyo Seon
AU - Huh, Yong Min
AU - Haam, Seungjoo
PY - 2012/12/1
Y1 - 2012/12/1
N2 - Carboxymethyl-dextran (CM-dextran) replaced the hydrophobic oleylamine ligands on the surfaces of MnO nanoparticles, rendering them highly water-soluble by allowing direct contact with excited water protons. Solution MRI studies of the two types of nanoparticles, exchanged and bilayered, with different core sizes have shown that the exchanged ligand structure exhibits significantly enhanced longitudinal relaxation. The modification with dextran converted the nanoparticles into effective T1 MRI contrast agents, as well as promoting strong interactions with macrophages. Thus, it is a potential MR contrast agent for visualizing inflammatory macrophages. Carboxymethyl-dextran can replace the hydrophobic oleylamine ligands on the surfaces of MnO nanoparticles, rendering them highly water-soluble by allowing direct contact with excited water protons. The modification to the dextran converts the nanoparticles into effective T1 MRI contrast agents, as well as promoting strong interactions with macrophages.
AB - Carboxymethyl-dextran (CM-dextran) replaced the hydrophobic oleylamine ligands on the surfaces of MnO nanoparticles, rendering them highly water-soluble by allowing direct contact with excited water protons. Solution MRI studies of the two types of nanoparticles, exchanged and bilayered, with different core sizes have shown that the exchanged ligand structure exhibits significantly enhanced longitudinal relaxation. The modification with dextran converted the nanoparticles into effective T1 MRI contrast agents, as well as promoting strong interactions with macrophages. Thus, it is a potential MR contrast agent for visualizing inflammatory macrophages. Carboxymethyl-dextran can replace the hydrophobic oleylamine ligands on the surfaces of MnO nanoparticles, rendering them highly water-soluble by allowing direct contact with excited water protons. The modification to the dextran converts the nanoparticles into effective T1 MRI contrast agents, as well as promoting strong interactions with macrophages.
UR - http://www.scopus.com/inward/record.url?scp=84871020131&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871020131&partnerID=8YFLogxK
U2 - 10.1002/ejic.201201026
DO - 10.1002/ejic.201201026
M3 - Article
AN - SCOPUS:84871020131
SP - 5960
EP - 5965
JO - Chemische Berichte
JF - Chemische Berichte
SN - 0009-2940
IS - 36
ER -