Effect of low-dose irradiation on induction of an apoptotic adaptive response in the murine system

J. Seong, Sung Hee Kim, Hong Ryul Pyo, Eun Ji Chung, Chang Ok Suh

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The aim of the study was to investigate the effect of low doses of irradiation on the induction of an apoptotic adaptive response in the murine system using C3H/HeJ mice bearing 8 mm syngeneic tumors, HCa-I and OCa-I. In OCa-I, the 0.05 Gy priming dose significantly reduced the 25 Gy-induced apoptosis by 30%, whereas this reduction was not seen in HCa-I. The analysis of apoptosis-regulating molecules showed that the application of a priming dose increased the radiation-induced p53 level in both tumors. No other regulators changed in OCa-I. However, in HCa-I, the application of a priming dose increased radiation-induced Bcl-XL and Bcl-XS, but not Bcl-2 or Bax. An apoptotic adaptive response induced by low-dose radiation was shown in one murine tumor, OCa-I and Bcl-XL and Bcl-XS appeared to be implicated.

Original languageEnglish
Pages (from-to)335-339
Number of pages5
JournalRadiation and Environmental Biophysics
Volume40
Issue number4
DOIs
Publication statusPublished - 2001 Dec 1

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiation
  • Environmental Science(all)

Cite this