Effect of low-dose ketamine on inflammatory response in off-pump coronary artery bypass graft surgery

J. E. Cho, J. K. Shim, Y. S. Choi, D. H. Kim, S. W. Hong, Y. L. Kwak

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background. Off-pump coronary artery bypass graft surgery (OPCAB) is still associated with a marked systemic inflammatory response. The aim of this study was to investigate whether pre-emptive, low dose of ketamine, which has been reported to have anti-inflammatory activity in on-pump coronary artery bypass surgery, could reduce inflammatory response in low-risk patients undergoing OPCAB. Methods. In this prospective randomized-controlled trial, 50 patients with stable angina and preserved myocardial function undergoing OPCAB were randomly assigned to receive either 0.5 mg kg-1 of ketamine (Ketamine group, n=25) or normal saline (Control group, n=25) during induction of anaesthesia. Inflammatory markers including C-reactive protein (CRP), interleukin (IL)-6, tumour necrosis factor-α (TNF-α), and cardiac enzymes were measured previous to induction (T1), 4 h after surgery (T2), and the first and second days after the surgery (T3 and T4). Results. There were no significant intergroup differences in the serum concentrations of the CRP, IL-6, and TNF-α and cardiac enzymes. Pro-inflammatory markers and cardiac enzymes, except TNF-α, were all increased after the surgery compared with baseline values in both groups. Conclusions. Low-dose ketamine administered during anaesthesia induction did not exert any evident anti-inflammatory effect in terms of reducing the serum concentrations of pro-inflammatory markers in low-risk patients undergoing OPCAB.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalBritish Journal of Anaesthesia
Volume102
Issue number1
DOIs
Publication statusPublished - 2009 Jan

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Off-Pump Coronary Artery Bypass
Ketamine
Coronary Artery Bypass
Transplants
Tumor Necrosis Factor-alpha
C-Reactive Protein
Interleukin-6
Anti-Inflammatory Agents
Enzymes
Anesthesia
Stable Angina
Serum
Ambulatory Surgical Procedures
Randomized Controlled Trials
Control Groups

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

Cho, J. E. ; Shim, J. K. ; Choi, Y. S. ; Kim, D. H. ; Hong, S. W. ; Kwak, Y. L. / Effect of low-dose ketamine on inflammatory response in off-pump coronary artery bypass graft surgery. In: British Journal of Anaesthesia. 2009 ; Vol. 102, No. 1. pp. 23-28.
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abstract = "Background. Off-pump coronary artery bypass graft surgery (OPCAB) is still associated with a marked systemic inflammatory response. The aim of this study was to investigate whether pre-emptive, low dose of ketamine, which has been reported to have anti-inflammatory activity in on-pump coronary artery bypass surgery, could reduce inflammatory response in low-risk patients undergoing OPCAB. Methods. In this prospective randomized-controlled trial, 50 patients with stable angina and preserved myocardial function undergoing OPCAB were randomly assigned to receive either 0.5 mg kg-1 of ketamine (Ketamine group, n=25) or normal saline (Control group, n=25) during induction of anaesthesia. Inflammatory markers including C-reactive protein (CRP), interleukin (IL)-6, tumour necrosis factor-α (TNF-α), and cardiac enzymes were measured previous to induction (T1), 4 h after surgery (T2), and the first and second days after the surgery (T3 and T4). Results. There were no significant intergroup differences in the serum concentrations of the CRP, IL-6, and TNF-α and cardiac enzymes. Pro-inflammatory markers and cardiac enzymes, except TNF-α, were all increased after the surgery compared with baseline values in both groups. Conclusions. Low-dose ketamine administered during anaesthesia induction did not exert any evident anti-inflammatory effect in terms of reducing the serum concentrations of pro-inflammatory markers in low-risk patients undergoing OPCAB.",
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Effect of low-dose ketamine on inflammatory response in off-pump coronary artery bypass graft surgery. / Cho, J. E.; Shim, J. K.; Choi, Y. S.; Kim, D. H.; Hong, S. W.; Kwak, Y. L.

In: British Journal of Anaesthesia, Vol. 102, No. 1, 01.2009, p. 23-28.

Research output: Contribution to journalArticle

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AU - Cho, J. E.

AU - Shim, J. K.

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AU - Kim, D. H.

AU - Hong, S. W.

AU - Kwak, Y. L.

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N2 - Background. Off-pump coronary artery bypass graft surgery (OPCAB) is still associated with a marked systemic inflammatory response. The aim of this study was to investigate whether pre-emptive, low dose of ketamine, which has been reported to have anti-inflammatory activity in on-pump coronary artery bypass surgery, could reduce inflammatory response in low-risk patients undergoing OPCAB. Methods. In this prospective randomized-controlled trial, 50 patients with stable angina and preserved myocardial function undergoing OPCAB were randomly assigned to receive either 0.5 mg kg-1 of ketamine (Ketamine group, n=25) or normal saline (Control group, n=25) during induction of anaesthesia. Inflammatory markers including C-reactive protein (CRP), interleukin (IL)-6, tumour necrosis factor-α (TNF-α), and cardiac enzymes were measured previous to induction (T1), 4 h after surgery (T2), and the first and second days after the surgery (T3 and T4). Results. There were no significant intergroup differences in the serum concentrations of the CRP, IL-6, and TNF-α and cardiac enzymes. Pro-inflammatory markers and cardiac enzymes, except TNF-α, were all increased after the surgery compared with baseline values in both groups. Conclusions. Low-dose ketamine administered during anaesthesia induction did not exert any evident anti-inflammatory effect in terms of reducing the serum concentrations of pro-inflammatory markers in low-risk patients undergoing OPCAB.

AB - Background. Off-pump coronary artery bypass graft surgery (OPCAB) is still associated with a marked systemic inflammatory response. The aim of this study was to investigate whether pre-emptive, low dose of ketamine, which has been reported to have anti-inflammatory activity in on-pump coronary artery bypass surgery, could reduce inflammatory response in low-risk patients undergoing OPCAB. Methods. In this prospective randomized-controlled trial, 50 patients with stable angina and preserved myocardial function undergoing OPCAB were randomly assigned to receive either 0.5 mg kg-1 of ketamine (Ketamine group, n=25) or normal saline (Control group, n=25) during induction of anaesthesia. Inflammatory markers including C-reactive protein (CRP), interleukin (IL)-6, tumour necrosis factor-α (TNF-α), and cardiac enzymes were measured previous to induction (T1), 4 h after surgery (T2), and the first and second days after the surgery (T3 and T4). Results. There were no significant intergroup differences in the serum concentrations of the CRP, IL-6, and TNF-α and cardiac enzymes. Pro-inflammatory markers and cardiac enzymes, except TNF-α, were all increased after the surgery compared with baseline values in both groups. Conclusions. Low-dose ketamine administered during anaesthesia induction did not exert any evident anti-inflammatory effect in terms of reducing the serum concentrations of pro-inflammatory markers in low-risk patients undergoing OPCAB.

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