Abstract
In this study, we evaluated the effect of platelet-rich plasma (PRP) on bone regeneration in an autogenous bone graft in a canine model. The mandibular premolar teeth had been bilaterally extracted previously, and the ridges had been allowed to heal for 3 months. After this period, continuity resection was performed on both sides of the mandible. One defect (the PRP group) was reconstructed with the original particulate bone mixed with PRP. As a control, the contralateral defect (non-PRP group) was reconstructed with the original particulate bone alone. Biopsies after 6 weeks showed lower levels of bone formation in the PRP group than in the non-PRP group, and fluorescence microscopy revealed a delay in the remodelling of grafts loaded with PRP. These findings suggest that the addition of PRP does not appear to enhance new bone formation in autogenous bone grafts.
| Original language | English |
|---|---|
| Pages (from-to) | 56-59 |
| Number of pages | 4 |
| Journal | International Journal of Oral and Maxillofacial Surgery |
| Volume | 33 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2004 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Oral Surgery
- Otorhinolaryngology
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Effect of platelet-rich plasma on bone regeneration in autogenous bone graft. / Choi, Byungho; Im, C. J.; Huh, J. Y.; Suh, J. J.; Lee, S. H.
In: International Journal of Oral and Maxillofacial Surgery, Vol. 33, No. 1, 01.01.2004, p. 56-59.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effect of platelet-rich plasma on bone regeneration in autogenous bone graft
AU - Choi, Byungho
AU - Im, C. J.
AU - Huh, J. Y.
AU - Suh, J. J.
AU - Lee, S. H.
PY - 2004/1/1
Y1 - 2004/1/1
N2 - In this study, we evaluated the effect of platelet-rich plasma (PRP) on bone regeneration in an autogenous bone graft in a canine model. The mandibular premolar teeth had been bilaterally extracted previously, and the ridges had been allowed to heal for 3 months. After this period, continuity resection was performed on both sides of the mandible. One defect (the PRP group) was reconstructed with the original particulate bone mixed with PRP. As a control, the contralateral defect (non-PRP group) was reconstructed with the original particulate bone alone. Biopsies after 6 weeks showed lower levels of bone formation in the PRP group than in the non-PRP group, and fluorescence microscopy revealed a delay in the remodelling of grafts loaded with PRP. These findings suggest that the addition of PRP does not appear to enhance new bone formation in autogenous bone grafts.
AB - In this study, we evaluated the effect of platelet-rich plasma (PRP) on bone regeneration in an autogenous bone graft in a canine model. The mandibular premolar teeth had been bilaterally extracted previously, and the ridges had been allowed to heal for 3 months. After this period, continuity resection was performed on both sides of the mandible. One defect (the PRP group) was reconstructed with the original particulate bone mixed with PRP. As a control, the contralateral defect (non-PRP group) was reconstructed with the original particulate bone alone. Biopsies after 6 weeks showed lower levels of bone formation in the PRP group than in the non-PRP group, and fluorescence microscopy revealed a delay in the remodelling of grafts loaded with PRP. These findings suggest that the addition of PRP does not appear to enhance new bone formation in autogenous bone grafts.
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UR - http://www.scopus.com/inward/citedby.url?scp=0346399659&partnerID=8YFLogxK
U2 - 10.1054/ijom.2003.0466
DO - 10.1054/ijom.2003.0466
M3 - Article
VL - 33
SP - 56
EP - 59
JO - International Journal of Oral and Maxillofacial Surgery
JF - International Journal of Oral and Maxillofacial Surgery
SN - 0901-5027
IS - 1
ER -