Effect of platelet-rich plasma on bone regeneration in autogenous bone graft

Byung Ho Choi, C. J. Im, J. Y. Huh, J. J. Suh, S. H. Lee

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

In this study, we evaluated the effect of platelet-rich plasma (PRP) on bone regeneration in an autogenous bone graft in a canine model. The mandibular premolar teeth had been bilaterally extracted previously, and the ridges had been allowed to heal for 3 months. After this period, continuity resection was performed on both sides of the mandible. One defect (the PRP group) was reconstructed with the original particulate bone mixed with PRP. As a control, the contralateral defect (non-PRP group) was reconstructed with the original particulate bone alone. Biopsies after 6 weeks showed lower levels of bone formation in the PRP group than in the non-PRP group, and fluorescence microscopy revealed a delay in the remodelling of grafts loaded with PRP. These findings suggest that the addition of PRP does not appear to enhance new bone formation in autogenous bone grafts.

Original languageEnglish
Pages (from-to)56-59
Number of pages4
JournalInternational journal of oral and maxillofacial surgery
Volume33
Issue number1
DOIs
Publication statusPublished - 2004 Jan

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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