Abstract
In this study, we evaluated the effect of platelet-rich plasma (PRP) on bone regeneration in an autogenous bone graft in a canine model. The mandibular premolar teeth had been bilaterally extracted previously, and the ridges had been allowed to heal for 3 months. After this period, continuity resection was performed on both sides of the mandible. One defect (the PRP group) was reconstructed with the original particulate bone mixed with PRP. As a control, the contralateral defect (non-PRP group) was reconstructed with the original particulate bone alone. Biopsies after 6 weeks showed lower levels of bone formation in the PRP group than in the non-PRP group, and fluorescence microscopy revealed a delay in the remodelling of grafts loaded with PRP. These findings suggest that the addition of PRP does not appear to enhance new bone formation in autogenous bone grafts.
| Original language | English |
|---|---|
| Pages (from-to) | 56-59 |
| Number of pages | 4 |
| Journal | International journal of oral and maxillofacial surgery |
| Volume | 33 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2004 Jan |
Bibliographical note
Funding Information:Acknowledgments. This study was sup ported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea to Choi, Byung-Ho (02-PJ1-PG1-CH07-0001).
All Science Journal Classification (ASJC) codes
- Surgery
- Oral Surgery
- Otorhinolaryngology