In this study, we evaluated the effect of platelet-rich plasma (PRP) on bone regeneration in an autogenous bone graft in a canine model. The mandibular premolar teeth had been bilaterally extracted previously, and the ridges had been allowed to heal for 3 months. After this period, continuity resection was performed on both sides of the mandible. One defect (the PRP group) was reconstructed with the original particulate bone mixed with PRP. As a control, the contralateral defect (non-PRP group) was reconstructed with the original particulate bone alone. Biopsies after 6 weeks showed lower levels of bone formation in the PRP group than in the non-PRP group, and fluorescence microscopy revealed a delay in the remodelling of grafts loaded with PRP. These findings suggest that the addition of PRP does not appear to enhance new bone formation in autogenous bone grafts.
|Number of pages||4|
|Journal||International journal of oral and maxillofacial surgery|
|Publication status||Published - 2004 Jan|
Bibliographical noteFunding Information:
Acknowledgments. This study was sup ported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea to Choi, Byung-Ho (02-PJ1-PG1-CH07-0001).
All Science Journal Classification (ASJC) codes
- Oral Surgery