Abstract
In this study, we evaluated the effect of platelet-rich plasma (PRP) on bone regeneration in an autogenous bone graft in a canine model. The mandibular premolar teeth had been bilaterally extracted previously, and the ridges had been allowed to heal for 3 months. After this period, continuity resection was performed on both sides of the mandible. One defect (the PRP group) was reconstructed with the original particulate bone mixed with PRP. As a control, the contralateral defect (non-PRP group) was reconstructed with the original particulate bone alone. Biopsies after 6 weeks showed lower levels of bone formation in the PRP group than in the non-PRP group, and fluorescence microscopy revealed a delay in the remodelling of grafts loaded with PRP. These findings suggest that the addition of PRP does not appear to enhance new bone formation in autogenous bone grafts.
Original language | English |
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Pages (from-to) | 56-59 |
Number of pages | 4 |
Journal | International journal of oral and maxillofacial surgery |
Volume | 33 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2004 Jan |
Bibliographical note
Funding Information:Acknowledgments. This study was sup ported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea to Choi, Byung-Ho (02-PJ1-PG1-CH07-0001).
All Science Journal Classification (ASJC) codes
- Surgery
- Oral Surgery
- Otorhinolaryngology