Effect of Polymer Type on the Dissolution Profile of a Solid Dispersion of Cilostazol

Deokkeun Lee, Eun Sol Ha, Dong Hyeon Ha, Woo Yong Sim, Ji Eun Choi, Min Soo Kim, Cheong Weon Cho, Sung Joo Hwang

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)370-373
Number of pages4
JournalBulletin of the Korean Chemical Society
Issue number4
Publication statusPublished - 2019 Apr

Bibliographical note

Funding Information:
itory effect of a polymer on the crystallization of supersaturated cilostazol using solvent-shift method,35 we prepared a solution of cilostazol at 25 mg/mL in dimethyl sulfoxide (DMSO). Subsequently, we added 1 mL of this solution into 500 mL of the dissolution medium at pH 1.2 or 6.8 containing 0.1% of the polymer (Eudragit E, Eudragit E/HCl, Eudragit L, Eudragit S, or HPMC 2910) and measured the rate of dissolution according to the KP XI paddle method at a paddle rotation of 100 rpm by using a Varian VK 7000 dissolution apparatus in a constant temperature bath at 37 °C ± 0.5 °C. Samples (3 mL) were drawn from the vials at different time intervals and passed through 0.45-μm regenerated cellulose syringe filters. Filtered samples were diluted in methanol before HPLC analysis. Acknowledgments. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2017R1C1B1006483).

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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