Effect of pre existing respiratory conditions on survival of lung cancer patients: A nationwide population-based cohort study

Seri Hong, Eun Cheol Park, Tae Hyun Kim, Jeoung A. Kwon, Ki Bong Yoo, Kyu Tae Han, Ji Won Yoo, Sun Jung Kim

Research output: Contribution to journalArticle

Abstract

Background: Common diseases with potential to increase the risk of death from lung cancer have so far not been studied in large populations. Methods: We did a population-based retrospective cohort study using nationwide health insurance claims data from 2005 to 2012 in Korea including 205 403 lung cancer patients. Multivariate-adjusted hazard ratios (aHRs) of lung cancer mortality by presence, time intervals with lung cancer diagnosis and combinations of pre-existing chronic obstructive pulmonary disease (COPD), pneumonia, asthma and tuberculosis were calculated using the Cox-proportional hazards model. Results: The total number of person-years of follow-up was 397 780 and 60.2% of patients died (mean survival 23.2 months after lung cancer diagnosis). Lung cancer patients with previous respiratory disease had increased aHR for mortality (COPD, hazard ratio [HR] = 1.32, CI 1.29–1.35; pneumonia, HR = 1.14, CI 1.08–1.19; and asthma, HR = 1.11, CI 1.06–1.16). Risks were positively associated with longer duration of pre-existing disease diagnosis; cases with >5 years since diagnosis compared to <2 years: COPD, HR = 2.91, CI 2.82–3.00; pneumonia, HR = 1.67, CI 1.51–1.85; asthma, HR = 1.56, CI 1.45–1.68; and tuberculosis, HR = 2.03, CI 1.90–2.17. Furthermore, elevated HRs of death were found among patients with multiple pre-existing co-morbidities. Conclusion: Hazards of death from lung cancer are significantly increased in cases with pre-existing lung disease, and worse with longer durations, and with multiple combinations before cancer diagnosis. Patients and physicians should be aware of these meaningful risk/prognostic factors for lung cancer when identifying high-risk patient groups.

Original languageEnglish
Pages (from-to)e71-e80
JournalAsia-Pacific Journal of Clinical Oncology
Volume14
Issue number2
DOIs
Publication statusPublished - 2018 Apr

Fingerprint

Preexisting Condition Coverage
Lung Neoplasms
Cohort Studies
Survival
Population
Chronic Obstructive Pulmonary Disease
Pneumonia
Asthma
Mortality
Health Insurance
Korea
Pulmonary Tuberculosis
Proportional Hazards Models
Lung Diseases
Tuberculosis
Retrospective Studies
Morbidity
Physicians

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Hong, Seri ; Park, Eun Cheol ; Kim, Tae Hyun ; Kwon, Jeoung A. ; Yoo, Ki Bong ; Han, Kyu Tae ; Yoo, Ji Won ; Kim, Sun Jung. / Effect of pre existing respiratory conditions on survival of lung cancer patients : A nationwide population-based cohort study. In: Asia-Pacific Journal of Clinical Oncology. 2018 ; Vol. 14, No. 2. pp. e71-e80.
@article{6e54393fd4124740aa2c87cea7862337,
title = "Effect of pre existing respiratory conditions on survival of lung cancer patients: A nationwide population-based cohort study",
abstract = "Background: Common diseases with potential to increase the risk of death from lung cancer have so far not been studied in large populations. Methods: We did a population-based retrospective cohort study using nationwide health insurance claims data from 2005 to 2012 in Korea including 205 403 lung cancer patients. Multivariate-adjusted hazard ratios (aHRs) of lung cancer mortality by presence, time intervals with lung cancer diagnosis and combinations of pre-existing chronic obstructive pulmonary disease (COPD), pneumonia, asthma and tuberculosis were calculated using the Cox-proportional hazards model. Results: The total number of person-years of follow-up was 397 780 and 60.2{\%} of patients died (mean survival 23.2 months after lung cancer diagnosis). Lung cancer patients with previous respiratory disease had increased aHR for mortality (COPD, hazard ratio [HR] = 1.32, CI 1.29–1.35; pneumonia, HR = 1.14, CI 1.08–1.19; and asthma, HR = 1.11, CI 1.06–1.16). Risks were positively associated with longer duration of pre-existing disease diagnosis; cases with >5 years since diagnosis compared to <2 years: COPD, HR = 2.91, CI 2.82–3.00; pneumonia, HR = 1.67, CI 1.51–1.85; asthma, HR = 1.56, CI 1.45–1.68; and tuberculosis, HR = 2.03, CI 1.90–2.17. Furthermore, elevated HRs of death were found among patients with multiple pre-existing co-morbidities. Conclusion: Hazards of death from lung cancer are significantly increased in cases with pre-existing lung disease, and worse with longer durations, and with multiple combinations before cancer diagnosis. Patients and physicians should be aware of these meaningful risk/prognostic factors for lung cancer when identifying high-risk patient groups.",
author = "Seri Hong and Park, {Eun Cheol} and Kim, {Tae Hyun} and Kwon, {Jeoung A.} and Yoo, {Ki Bong} and Han, {Kyu Tae} and Yoo, {Ji Won} and Kim, {Sun Jung}",
year = "2018",
month = "4",
doi = "10.1111/ajco.12697",
language = "English",
volume = "14",
pages = "e71--e80",
journal = "Asia-Pacific Journal of Clinical Oncology",
issn = "1743-7555",
publisher = "Wiley-Blackwell",
number = "2",

}

Effect of pre existing respiratory conditions on survival of lung cancer patients : A nationwide population-based cohort study. / Hong, Seri; Park, Eun Cheol; Kim, Tae Hyun; Kwon, Jeoung A.; Yoo, Ki Bong; Han, Kyu Tae; Yoo, Ji Won; Kim, Sun Jung.

In: Asia-Pacific Journal of Clinical Oncology, Vol. 14, No. 2, 04.2018, p. e71-e80.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of pre existing respiratory conditions on survival of lung cancer patients

T2 - A nationwide population-based cohort study

AU - Hong, Seri

AU - Park, Eun Cheol

AU - Kim, Tae Hyun

AU - Kwon, Jeoung A.

AU - Yoo, Ki Bong

AU - Han, Kyu Tae

AU - Yoo, Ji Won

AU - Kim, Sun Jung

PY - 2018/4

Y1 - 2018/4

N2 - Background: Common diseases with potential to increase the risk of death from lung cancer have so far not been studied in large populations. Methods: We did a population-based retrospective cohort study using nationwide health insurance claims data from 2005 to 2012 in Korea including 205 403 lung cancer patients. Multivariate-adjusted hazard ratios (aHRs) of lung cancer mortality by presence, time intervals with lung cancer diagnosis and combinations of pre-existing chronic obstructive pulmonary disease (COPD), pneumonia, asthma and tuberculosis were calculated using the Cox-proportional hazards model. Results: The total number of person-years of follow-up was 397 780 and 60.2% of patients died (mean survival 23.2 months after lung cancer diagnosis). Lung cancer patients with previous respiratory disease had increased aHR for mortality (COPD, hazard ratio [HR] = 1.32, CI 1.29–1.35; pneumonia, HR = 1.14, CI 1.08–1.19; and asthma, HR = 1.11, CI 1.06–1.16). Risks were positively associated with longer duration of pre-existing disease diagnosis; cases with >5 years since diagnosis compared to <2 years: COPD, HR = 2.91, CI 2.82–3.00; pneumonia, HR = 1.67, CI 1.51–1.85; asthma, HR = 1.56, CI 1.45–1.68; and tuberculosis, HR = 2.03, CI 1.90–2.17. Furthermore, elevated HRs of death were found among patients with multiple pre-existing co-morbidities. Conclusion: Hazards of death from lung cancer are significantly increased in cases with pre-existing lung disease, and worse with longer durations, and with multiple combinations before cancer diagnosis. Patients and physicians should be aware of these meaningful risk/prognostic factors for lung cancer when identifying high-risk patient groups.

AB - Background: Common diseases with potential to increase the risk of death from lung cancer have so far not been studied in large populations. Methods: We did a population-based retrospective cohort study using nationwide health insurance claims data from 2005 to 2012 in Korea including 205 403 lung cancer patients. Multivariate-adjusted hazard ratios (aHRs) of lung cancer mortality by presence, time intervals with lung cancer diagnosis and combinations of pre-existing chronic obstructive pulmonary disease (COPD), pneumonia, asthma and tuberculosis were calculated using the Cox-proportional hazards model. Results: The total number of person-years of follow-up was 397 780 and 60.2% of patients died (mean survival 23.2 months after lung cancer diagnosis). Lung cancer patients with previous respiratory disease had increased aHR for mortality (COPD, hazard ratio [HR] = 1.32, CI 1.29–1.35; pneumonia, HR = 1.14, CI 1.08–1.19; and asthma, HR = 1.11, CI 1.06–1.16). Risks were positively associated with longer duration of pre-existing disease diagnosis; cases with >5 years since diagnosis compared to <2 years: COPD, HR = 2.91, CI 2.82–3.00; pneumonia, HR = 1.67, CI 1.51–1.85; asthma, HR = 1.56, CI 1.45–1.68; and tuberculosis, HR = 2.03, CI 1.90–2.17. Furthermore, elevated HRs of death were found among patients with multiple pre-existing co-morbidities. Conclusion: Hazards of death from lung cancer are significantly increased in cases with pre-existing lung disease, and worse with longer durations, and with multiple combinations before cancer diagnosis. Patients and physicians should be aware of these meaningful risk/prognostic factors for lung cancer when identifying high-risk patient groups.

UR - http://www.scopus.com/inward/record.url?scp=85026524681&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85026524681&partnerID=8YFLogxK

U2 - 10.1111/ajco.12697

DO - 10.1111/ajco.12697

M3 - Article

C2 - 28762660

AN - SCOPUS:85026524681

VL - 14

SP - e71-e80

JO - Asia-Pacific Journal of Clinical Oncology

JF - Asia-Pacific Journal of Clinical Oncology

SN - 1743-7555

IS - 2

ER -