Effect of Prophylactic Brimonidine Instillation on Bleeding During Strabismus Surgery in Adults

Samin Hong, chanyun kim, Gong Je Seong, Sueng Han Han

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5 Citations (Scopus)


Purpose: To investigate the effects of preoperative brimonidine-purite 0.15% instillation on intraoperative bleeding and postoperative subconjunctival hemorrhage during strabismus surgery in adult patients. Design: Randomized comparative interventional case series. Methods: One hundred and eighteen eyes of 90 consecutive adult patients were instilled with either a single drop of brimonidine-purite 0.15% (42 eyes), phenylephrine 1% (38 eyes), or sodium hyaluronate 0.1% (38 eyes) 15 minutes prior to strabismus surgery. Intraoperative bleeding and postoperative subconjunctival hemorrhage were graded on a scale of one to three. The scores were compared among the study groups. Results: Scores of the intraoperative bleeding and the postoperative subconjunctival hemorrhage of the treatment groups were significantly less than that of the control group (P < .001). The scores of the brimonidine group were similar to those of the phenylephrine group (intraoperative bleeding score, P = .405; subconjunctival hemorrhage score, P = .722). Conclusions: Topical brimonidine administration before strabismus surgery may reduce intraoperative bleeding and postoperative subconjunctival hemorrhage in adult patients.

Original languageEnglish
Pages (from-to)469-470
Number of pages2
JournalAmerican Journal of Ophthalmology
Issue number3
Publication statusPublished - 2007 Sep 1


All Science Journal Classification (ASJC) codes

  • Ophthalmology

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