Effect of recombinant human epidermal growth factor on cutaneous scar quality in thyroidectomy patients

Jung U. Shin, Sang Wook Kang, Jong Ju Jeong, Kee Hyun Nam, Woong Youn Chung, JuHee Lee

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Epidermal growth factor (EGF) decreases inflammatory cell infiltration and TGF-β expression during wound healing. Several clinical studies show that recovery of various ulcer wounds, such as diabetic and radiation ulcer, is promoted by EGF. Objective: To evaluate effects of recombinant human epidermal growth factor (rhEGF) on cutaneous scar quality after thyroidectomy. Method: Scar quality was evaluated by Vancouver scar scale (VSS) in two groups of female thyroidectomy patients (control, n=11; rhEGF-treated, n=10). Scar erythema, pigmentation, elasticity and hydration were measured by mexameter, cutometer and corneometer. Results: Scar pliability (at 4 weeks) and thickness (2 weeks) after surgery were significantly lower in the rhEGF group than control. Total VSS score was significantly lower in the rhEGF group after 4 weeks. However, erythema, pigmentation, elasticity and hydration of the scar were not significantly different between groups. Conclusion: The early use of rhEGF in surgical wound healing may improve cutaneous scar quality.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalJournal of Dermatological Treatment
Volume26
Issue number2
DOIs
Publication statusPublished - 2015 Apr 1

All Science Journal Classification (ASJC) codes

  • Dermatology

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