Effect of Renin−Angiotensin−Aldosterone System Blockade on Outcomes in Patients With ESRD: A Prospective Cohort Study in Korea

Clinical Research Center of End Stage Renal Disease Investigators

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2 Citations (Scopus)


Introduction: Conflicting results still exist regarding the benefit of renin−angiotensin−aldosterone system (RAAS) blockade on clinical outcomes in dialysis patients. The aim of this study was to evaluate the effects of RAAS blockade on survival in Korean patients with end-stage renal disease (ESRD). Methods: Our analysis was based on the data of 5223 patients enrolled from the Clinical Research Center for ESRD, a nationwide prospective observational cohort. Multivariate Cox regression was applied for risk factor analysis with the cumulative duration of RAAS blockade use as time-varying covariate. The risks for mortality from all causes and major cardiovascular event−free survival were estimated. Results: Compared to the control group, patients in the RAAS group were younger but had a higher proportion of diabetes mellitus, had higher systolic blood pressure, required a greater number of prescribed antihypertensive drugs, and had a longer dialysis duration. On multivariate time-varying Cox regression analysis, the RAAS group with cumulative duration of >90 days was significantly associated with a lower risk of mortality from all causes after adjustment for confounding (hazard ratio [HR] = 0.45, 95% confidence interval [CI] = 0.35–0.58, P < 0.0001). Major cardiovascular event−free survival was also better for the RAAS group than for the control group on multivariate analysis (HR = 0.27, 95% CI = 0.20–0.37, P < 0.0001), considering the cumulative duration of RAAS blockade use. Conclusion: In Korean patients with ESRD, we reported a specific benefit of RAAS blockade in improving overall survival after adjustment for confounding factors from real-world data.

Original languageEnglish
Pages (from-to)1385-1393
Number of pages9
JournalKidney International Reports
Issue number6
Publication statusPublished - 2018 Nov

Bibliographical note

Funding Information:
This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea ( HC15C1129 ). We express our enormous gratitude to all of the Clinical Research Center for End Stage Renal Disease investigators.

Publisher Copyright:
© 2018 International Society of Nephrology

All Science Journal Classification (ASJC) codes

  • Nephrology


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