Effect of serial use of bone morphogenetic protein 2 and fibroblast growth factor 2 on periodontal tissue regeneration

Ah Reum Lee, Hyunmin Choi, Jee Hwan Kim, Sung Won Cho, Young Bum Park

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Purpose: This study evaluates the synergistic effect of serial application of bone morphogenetic protein 2 (BMP2) and fibroblast growth factor 2 (FGF2) on both new bone formation and periodontal tissue regeneration using 1-wall intrabony defect in mongrel dogs. Materials and Methods: Onewall defects were created at the mesial aspect of the mandibular first molars of 6 male mongrel dogs. Each mandibular defect received 1 of the 2 experimental treatments randomly (BMP2 or BMP2 + FGF2), and it was allowed to heal for either 4 or 8 weeks postoperatively. Histologic and histomorphometric analyses were performed for the evaluation of the overall healing patterns of new bone formation and periodontal tissue regeneration. Results: The results showed that after 8 weeks, serial application of BMP2 and FGF2 significantly improved the periodontal tissue regeneration, whereas application of BMP2 only showed greater new bone formation after 4 weeks. Conclusions: The serial application of BMP2 and FGF2 may have synergistic effects on periodontal tissue regeneration over time. (Implant Dent 2017;26:664-673).

Original languageEnglish
Pages (from-to)664-673
Number of pages10
JournalImplant dentistry
Volume26
Issue number5
DOIs
Publication statusPublished - 2017 Oct 1

All Science Journal Classification (ASJC) codes

  • Oral Surgery

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