Effect of sevoflurane on grafted kidney function in renal transplantation

Jin Ha Park, Jae Hoon Lee, Dong Jin Joo, Ki Jun Song, YuSeun Kim, Bon Nyeo Koo

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: The objective of this retrospective study was to determine if there are any differences in grafted kidney function in recipients of kidney transplantation (KT) when donors and recipients were anesthetized with sevoflurane compared to desflurane. Methods: Seventy-three pairs of donors-recipients were anesthetized with sevoflurane (Sevo group) and 71 pairs were anesthetized with desflurane (Des group). We retrospectively investigated the blood urea nitrogen (BUN) levels, creatinine (Cr) levels, and estimated glomerular filtration rates (eGFR) of the recipients in both groups for 1 year postoperatively. We tested non-inferiority for serum creatinine at discharge and 1 year after KT. Short-term (1 year) outcomes of KT were assessed by the incidence of delayed graft function (DGF), acute rejection episodes (ARE), and graft failure. Results: There were no differences in BUN, Cr, eGFR, or outcomes of KT at 1 year postoperatively. Specifically, the 95% confidence interval for the difference in creatinine levels between the Sevo and Des groups was less than the margin of equivalence at the time of discharge and 1 year after surgery. The occurrences of DGF, ARE, and graft failure were comparable between the groups. Conclusions: Compared to desflurane, sevoflurane had no adverse effects on grafted renal function or on the shortterm outcome of renal transplantation.

Original languageEnglish
Pages (from-to)529-535
Number of pages7
JournalKorean Journal of Anesthesiology
Volume62
Issue number6
DOIs
Publication statusPublished - 2012 Jun 1

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Kidney Transplantation
Creatinine
Kidney
Delayed Graft Function
Blood Urea Nitrogen
Graft Rejection
Glomerular Filtration Rate
Retrospective Studies
sevoflurane
Confidence Intervals
Incidence
Serum
desflurane

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

Park, Jin Ha ; Lee, Jae Hoon ; Joo, Dong Jin ; Song, Ki Jun ; Kim, YuSeun ; Koo, Bon Nyeo. / Effect of sevoflurane on grafted kidney function in renal transplantation. In: Korean Journal of Anesthesiology. 2012 ; Vol. 62, No. 6. pp. 529-535.
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abstract = "Background: The objective of this retrospective study was to determine if there are any differences in grafted kidney function in recipients of kidney transplantation (KT) when donors and recipients were anesthetized with sevoflurane compared to desflurane. Methods: Seventy-three pairs of donors-recipients were anesthetized with sevoflurane (Sevo group) and 71 pairs were anesthetized with desflurane (Des group). We retrospectively investigated the blood urea nitrogen (BUN) levels, creatinine (Cr) levels, and estimated glomerular filtration rates (eGFR) of the recipients in both groups for 1 year postoperatively. We tested non-inferiority for serum creatinine at discharge and 1 year after KT. Short-term (1 year) outcomes of KT were assessed by the incidence of delayed graft function (DGF), acute rejection episodes (ARE), and graft failure. Results: There were no differences in BUN, Cr, eGFR, or outcomes of KT at 1 year postoperatively. Specifically, the 95{\%} confidence interval for the difference in creatinine levels between the Sevo and Des groups was less than the margin of equivalence at the time of discharge and 1 year after surgery. The occurrences of DGF, ARE, and graft failure were comparable between the groups. Conclusions: Compared to desflurane, sevoflurane had no adverse effects on grafted renal function or on the shortterm outcome of renal transplantation.",
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Effect of sevoflurane on grafted kidney function in renal transplantation. / Park, Jin Ha; Lee, Jae Hoon; Joo, Dong Jin; Song, Ki Jun; Kim, YuSeun; Koo, Bon Nyeo.

In: Korean Journal of Anesthesiology, Vol. 62, No. 6, 01.06.2012, p. 529-535.

Research output: Contribution to journalArticle

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AU - Lee, Jae Hoon

AU - Joo, Dong Jin

AU - Song, Ki Jun

AU - Kim, YuSeun

AU - Koo, Bon Nyeo

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