Effect of sodium lauryl sulfate on recurrent aphthous stomatitis: A randomized controlled clinical trial

Y. J. Shim, J. H. Choi, H. J. Ahn, J. S. Kwon

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Objective: To compare the effects of sodium lauryl sulfate (SLS)-free and SLS-containing dentifrice in patient with recurrent aphthous stomatitis (RAS). Materials and methods: The design of this study was a double-blind crossover trial. The 90 subjects were divided into three groups: group I used SLS-free (a commercially available SLS-free dentifrice) and SLS-A (SLS-free+1.5% SLS), group II used SLS-A and SLS-B (a commercially available 1.5% SLS-containing dentifrice), and group III used SLS-free and SLS-B. The subjects used one of the two assigned dentifrices for 8weeks and then the other for the following 8weeks. The order of the dentifrices used was selected at random, and there was a 2-week washout period between the two phases. The clinical parameters (number of ulcers, number of episodes, duration of ulcers, mean pain score) were compared between the two phases for each group. Results: The number of ulcers and episodes did not differ significantly between SLS-A, SLS-B, and SLS-free. Only duration of ulcers and mean pain score was significantly decreased during the period using SLS-free. Conclusion: Although SLS-free did not reduce the number of ulcers and episodes, it affected the ulcer-healing process and reduces pain in daily lives in patients with RAS.

Original languageEnglish
Pages (from-to)655-660
Number of pages6
JournalOral Diseases
Volume18
Issue number7
DOIs
Publication statusPublished - 2012 Oct

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Dentistry(all)

Fingerprint

Dive into the research topics of 'Effect of sodium lauryl sulfate on recurrent aphthous stomatitis: A randomized controlled clinical trial'. Together they form a unique fingerprint.

Cite this