Effect of subdermal 1,444-nm pulsed neodymium-doped yttrium aluminum garnet laser on the nasolabial folds and cheek laxity

Soo Hyun Lee, Mi Ryung Roh, Jin Young Jung, Hyunjoong Jee, Kyoung Ae Nam, Kee Yang Chung

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Wrinkle formation usually accompanies skin aging. In particular, accentuated nasolabial folds and loss of elasticity are early signs of skin aging. The use of 1,444-nm pulsed neodymium-doped yttrium aluminum garnet (Nd:YAG) lasers has increased in popularity. Objective To evaluate the safety and efficacy of a novel 1,444-nm pulsed Nd:YAG laser in the treatment of NLF and cheek laxity using subdermal laser therapy. Methods: Ten Korean patients with moderate to severe NLF were enrolled. Each received a single treatment session with a 1,444-nm Nd:YAG laser. Two blinded physicians evaluated clinical improvement by rating comparative photographs on a 5-point scale. Efficacy was also assessed by measuring elasticity and roughness. Skin biopsies were performed on five volunteers before treatment and 3 months after treatment. Results: The 1,444-nm Nd:YAG laser effectively promoted clinical improvement of NLF and cheek laxity (p <.05). Significant differences in elasticity and roughness were observed (p <.05). Epidermal proliferation was stimulated as demonstrated by increases in epidermal thickness and Ki-67 expression (p <.05). Quantitative image analyses of pre- and post-treatment biopsies revealed that collagen fibers increased from baseline (p >.05). Transforming growth factor beta and heat shock protein-70 messenger RNA levels quantified using real-time reverse transcriptase polymerase chain reaction increased significantly from baseline (p <.05). Conclusion: The 1,444-nm Nd:YAG laser is an effective treatment modality with minimal complications for the treatment of NLF and cheek laxity, but further research with a larger group of patients is needed to confirm these findings.

Original languageEnglish
Pages (from-to)1067-1078
Number of pages12
JournalDermatologic Surgery
Volume39
Issue number7
DOIs
Publication statusPublished - 2013 Jul 1

Fingerprint

Nasolabial Fold
Cheek
Solid-State Lasers
Skin Aging
Elasticity
Therapeutics
HSP70 Heat-Shock Proteins
Laser Therapy
Reverse Transcriptase Polymerase Chain Reaction
Transforming Growth Factor beta
Real-Time Polymerase Chain Reaction
Volunteers
Physicians
Biopsy
Safety
Messenger RNA
Skin
Research

All Science Journal Classification (ASJC) codes

  • Surgery
  • Dermatology

Cite this

Lee, Soo Hyun ; Roh, Mi Ryung ; Jung, Jin Young ; Jee, Hyunjoong ; Nam, Kyoung Ae ; Chung, Kee Yang. / Effect of subdermal 1,444-nm pulsed neodymium-doped yttrium aluminum garnet laser on the nasolabial folds and cheek laxity. In: Dermatologic Surgery. 2013 ; Vol. 39, No. 7. pp. 1067-1078.
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abstract = "Background: Wrinkle formation usually accompanies skin aging. In particular, accentuated nasolabial folds and loss of elasticity are early signs of skin aging. The use of 1,444-nm pulsed neodymium-doped yttrium aluminum garnet (Nd:YAG) lasers has increased in popularity. Objective To evaluate the safety and efficacy of a novel 1,444-nm pulsed Nd:YAG laser in the treatment of NLF and cheek laxity using subdermal laser therapy. Methods: Ten Korean patients with moderate to severe NLF were enrolled. Each received a single treatment session with a 1,444-nm Nd:YAG laser. Two blinded physicians evaluated clinical improvement by rating comparative photographs on a 5-point scale. Efficacy was also assessed by measuring elasticity and roughness. Skin biopsies were performed on five volunteers before treatment and 3 months after treatment. Results: The 1,444-nm Nd:YAG laser effectively promoted clinical improvement of NLF and cheek laxity (p <.05). Significant differences in elasticity and roughness were observed (p <.05). Epidermal proliferation was stimulated as demonstrated by increases in epidermal thickness and Ki-67 expression (p <.05). Quantitative image analyses of pre- and post-treatment biopsies revealed that collagen fibers increased from baseline (p >.05). Transforming growth factor beta and heat shock protein-70 messenger RNA levels quantified using real-time reverse transcriptase polymerase chain reaction increased significantly from baseline (p <.05). Conclusion: The 1,444-nm Nd:YAG laser is an effective treatment modality with minimal complications for the treatment of NLF and cheek laxity, but further research with a larger group of patients is needed to confirm these findings.",
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Effect of subdermal 1,444-nm pulsed neodymium-doped yttrium aluminum garnet laser on the nasolabial folds and cheek laxity. / Lee, Soo Hyun; Roh, Mi Ryung; Jung, Jin Young; Jee, Hyunjoong; Nam, Kyoung Ae; Chung, Kee Yang.

In: Dermatologic Surgery, Vol. 39, No. 7, 01.07.2013, p. 1067-1078.

Research output: Contribution to journalArticle

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T1 - Effect of subdermal 1,444-nm pulsed neodymium-doped yttrium aluminum garnet laser on the nasolabial folds and cheek laxity

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AU - Roh, Mi Ryung

AU - Jung, Jin Young

AU - Jee, Hyunjoong

AU - Nam, Kyoung Ae

AU - Chung, Kee Yang

PY - 2013/7/1

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N2 - Background: Wrinkle formation usually accompanies skin aging. In particular, accentuated nasolabial folds and loss of elasticity are early signs of skin aging. The use of 1,444-nm pulsed neodymium-doped yttrium aluminum garnet (Nd:YAG) lasers has increased in popularity. Objective To evaluate the safety and efficacy of a novel 1,444-nm pulsed Nd:YAG laser in the treatment of NLF and cheek laxity using subdermal laser therapy. Methods: Ten Korean patients with moderate to severe NLF were enrolled. Each received a single treatment session with a 1,444-nm Nd:YAG laser. Two blinded physicians evaluated clinical improvement by rating comparative photographs on a 5-point scale. Efficacy was also assessed by measuring elasticity and roughness. Skin biopsies were performed on five volunteers before treatment and 3 months after treatment. Results: The 1,444-nm Nd:YAG laser effectively promoted clinical improvement of NLF and cheek laxity (p <.05). Significant differences in elasticity and roughness were observed (p <.05). Epidermal proliferation was stimulated as demonstrated by increases in epidermal thickness and Ki-67 expression (p <.05). Quantitative image analyses of pre- and post-treatment biopsies revealed that collagen fibers increased from baseline (p >.05). Transforming growth factor beta and heat shock protein-70 messenger RNA levels quantified using real-time reverse transcriptase polymerase chain reaction increased significantly from baseline (p <.05). Conclusion: The 1,444-nm Nd:YAG laser is an effective treatment modality with minimal complications for the treatment of NLF and cheek laxity, but further research with a larger group of patients is needed to confirm these findings.

AB - Background: Wrinkle formation usually accompanies skin aging. In particular, accentuated nasolabial folds and loss of elasticity are early signs of skin aging. The use of 1,444-nm pulsed neodymium-doped yttrium aluminum garnet (Nd:YAG) lasers has increased in popularity. Objective To evaluate the safety and efficacy of a novel 1,444-nm pulsed Nd:YAG laser in the treatment of NLF and cheek laxity using subdermal laser therapy. Methods: Ten Korean patients with moderate to severe NLF were enrolled. Each received a single treatment session with a 1,444-nm Nd:YAG laser. Two blinded physicians evaluated clinical improvement by rating comparative photographs on a 5-point scale. Efficacy was also assessed by measuring elasticity and roughness. Skin biopsies were performed on five volunteers before treatment and 3 months after treatment. Results: The 1,444-nm Nd:YAG laser effectively promoted clinical improvement of NLF and cheek laxity (p <.05). Significant differences in elasticity and roughness were observed (p <.05). Epidermal proliferation was stimulated as demonstrated by increases in epidermal thickness and Ki-67 expression (p <.05). Quantitative image analyses of pre- and post-treatment biopsies revealed that collagen fibers increased from baseline (p >.05). Transforming growth factor beta and heat shock protein-70 messenger RNA levels quantified using real-time reverse transcriptase polymerase chain reaction increased significantly from baseline (p <.05). Conclusion: The 1,444-nm Nd:YAG laser is an effective treatment modality with minimal complications for the treatment of NLF and cheek laxity, but further research with a larger group of patients is needed to confirm these findings.

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