Effect of subthalamic nucleus lesions in a 6-hydroxydopamine-induced rat parkinsonian model: Behavioral and biochemical studies

Yong Sup Hwang, Insop Shim, Bom Bee Lee, JinWoo Chang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Object. The purpose of this study was to determine whether subthalamic nucleus (STN) ablation caused by kainic acid can restore dopaminergic neurotransmission and improve motor deficits in a 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonian model. Methods. The authors investigated behavioral changes in rats displaying parkinsonian symptoms (6-OHDA-lesioned rats) after an STN lesion was created using kainic acid. They also measured levels of dopamine and its metabolites following tissue dissection. The results of this study showed that STN ablation led to behavioral improvement in parkinsonian motor deficits. Increased levels of dopamine were also observed in the striatum and globus pallidus externus (GPE). Conclusions. The results indicate that creation of an STN lesion in this hemiparkinsonian rat model may counteract some of the neurochemical changes within the striatum and GPE caused by the 6-OHDA, and influence striatal dopaminergic metabolism.

Original languageEnglish
Pages (from-to)284-287
Number of pages4
JournalJournal of Neurosurgery
Volume105
Issue number2
DOIs
Publication statusPublished - 2006 Aug 22

Fingerprint

Subthalamic Nucleus
Oxidopamine
Globus Pallidus
Kainic Acid
Dopamine
Corpus Striatum
Synaptic Transmission
Dissection

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Neuroscience(all)

Cite this

@article{848c62342211409da5790028b3a3f91d,
title = "Effect of subthalamic nucleus lesions in a 6-hydroxydopamine-induced rat parkinsonian model: Behavioral and biochemical studies",
abstract = "Object. The purpose of this study was to determine whether subthalamic nucleus (STN) ablation caused by kainic acid can restore dopaminergic neurotransmission and improve motor deficits in a 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonian model. Methods. The authors investigated behavioral changes in rats displaying parkinsonian symptoms (6-OHDA-lesioned rats) after an STN lesion was created using kainic acid. They also measured levels of dopamine and its metabolites following tissue dissection. The results of this study showed that STN ablation led to behavioral improvement in parkinsonian motor deficits. Increased levels of dopamine were also observed in the striatum and globus pallidus externus (GPE). Conclusions. The results indicate that creation of an STN lesion in this hemiparkinsonian rat model may counteract some of the neurochemical changes within the striatum and GPE caused by the 6-OHDA, and influence striatal dopaminergic metabolism.",
author = "Hwang, {Yong Sup} and Insop Shim and Lee, {Bom Bee} and JinWoo Chang",
year = "2006",
month = "8",
day = "22",
doi = "10.3171/jns.2006.105.2.284",
language = "English",
volume = "105",
pages = "284--287",
journal = "Journal of Neurosurgery",
issn = "0022-3085",
publisher = "American Association of Neurological Surgeons",
number = "2",

}

Effect of subthalamic nucleus lesions in a 6-hydroxydopamine-induced rat parkinsonian model : Behavioral and biochemical studies. / Hwang, Yong Sup; Shim, Insop; Lee, Bom Bee; Chang, JinWoo.

In: Journal of Neurosurgery, Vol. 105, No. 2, 22.08.2006, p. 284-287.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of subthalamic nucleus lesions in a 6-hydroxydopamine-induced rat parkinsonian model

T2 - Behavioral and biochemical studies

AU - Hwang, Yong Sup

AU - Shim, Insop

AU - Lee, Bom Bee

AU - Chang, JinWoo

PY - 2006/8/22

Y1 - 2006/8/22

N2 - Object. The purpose of this study was to determine whether subthalamic nucleus (STN) ablation caused by kainic acid can restore dopaminergic neurotransmission and improve motor deficits in a 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonian model. Methods. The authors investigated behavioral changes in rats displaying parkinsonian symptoms (6-OHDA-lesioned rats) after an STN lesion was created using kainic acid. They also measured levels of dopamine and its metabolites following tissue dissection. The results of this study showed that STN ablation led to behavioral improvement in parkinsonian motor deficits. Increased levels of dopamine were also observed in the striatum and globus pallidus externus (GPE). Conclusions. The results indicate that creation of an STN lesion in this hemiparkinsonian rat model may counteract some of the neurochemical changes within the striatum and GPE caused by the 6-OHDA, and influence striatal dopaminergic metabolism.

AB - Object. The purpose of this study was to determine whether subthalamic nucleus (STN) ablation caused by kainic acid can restore dopaminergic neurotransmission and improve motor deficits in a 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonian model. Methods. The authors investigated behavioral changes in rats displaying parkinsonian symptoms (6-OHDA-lesioned rats) after an STN lesion was created using kainic acid. They also measured levels of dopamine and its metabolites following tissue dissection. The results of this study showed that STN ablation led to behavioral improvement in parkinsonian motor deficits. Increased levels of dopamine were also observed in the striatum and globus pallidus externus (GPE). Conclusions. The results indicate that creation of an STN lesion in this hemiparkinsonian rat model may counteract some of the neurochemical changes within the striatum and GPE caused by the 6-OHDA, and influence striatal dopaminergic metabolism.

UR - http://www.scopus.com/inward/record.url?scp=33747283139&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33747283139&partnerID=8YFLogxK

U2 - 10.3171/jns.2006.105.2.284

DO - 10.3171/jns.2006.105.2.284

M3 - Article

C2 - 17219835

AN - SCOPUS:33747283139

VL - 105

SP - 284

EP - 287

JO - Journal of Neurosurgery

JF - Journal of Neurosurgery

SN - 0022-3085

IS - 2

ER -