Effect of subthalamic nucleus lesions in a 6-hydroxydopamine-induced rat parkinsonian model: Behavioral and biochemical studies

Yong Sup Hwang, Insop Shim, Bom Bee Lee, Jin Woo Chang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Object. The purpose of this study was to determine whether subthalamic nucleus (STN) ablation caused by kainic acid can restore dopaminergic neurotransmission and improve motor deficits in a 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonian model. Methods. The authors investigated behavioral changes in rats displaying parkinsonian symptoms (6-OHDA-lesioned rats) after an STN lesion was created using kainic acid. They also measured levels of dopamine and its metabolites following tissue dissection. The results of this study showed that STN ablation led to behavioral improvement in parkinsonian motor deficits. Increased levels of dopamine were also observed in the striatum and globus pallidus externus (GPE). Conclusions. The results indicate that creation of an STN lesion in this hemiparkinsonian rat model may counteract some of the neurochemical changes within the striatum and GPE caused by the 6-OHDA, and influence striatal dopaminergic metabolism.

Original languageEnglish
Pages (from-to)284-287
Number of pages4
JournalJournal of neurosurgery
Volume105
Issue number2
DOIs
Publication statusPublished - 2006

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

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