Effect of systemic blood pressure on optical coherence tomography angiography in glaucoma patients

Chan Keum Park, Kwanghyun Lee, Eun Woo Kim, Sangah Kim, Sang Yeop Lee, Chan Yun Kim, Gong Je Seong, Hyoung Won Bae

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Background: The association between retinal microvascular structure and glaucoma has been revealed in multiple studies using optical tomography angiography (OCTA), but limited information on the macular vessel density (mVD) in patients with glaucoma is available. In this study, we tried to identity the factors that affected macular VD (mVD) in glaucomatous eyes. Methods: This retrospective cross-sectional study evaluated OCT and OCTA images from 92 eyes from 58 healthy subjects and 179 eyes from 103 glaucoma patients using the SD-OCT database from July 2017 to July 2018. Glaucomatous eyes were further divided into two groups according to history of disc haemorrhage (DH). Association between mVD and demographic characteristics, ganglion cell-inner plexiform layer (GCIPL) thickness, visual field mean deviation (MD) and systemic blood pressure was analysed in each group. Results: In both healthy and glaucomatous eyes, mVD was inversely associated with age (β = −0.035, P = 0.025; β = −0.039, P = 0.018). In the glaucomatous eyes, mVD was significantly decreased, as the MD value was worse (β = 0.109, P = 0.002). In glaucomatous eyes with DH, mVD decreased as blood pressure increased (β = -0.111, P = 0.003) Conclusions: Reduced mVD is more common in older individuals in both healthy and glaucomatous eyes, and correlates with functional deterioration than structural damage in glaucomatous eyes. In glaucomatous eyes with DH, high systemic BP is associated with a reduction in mVD.

Original languageEnglish
Pages (from-to)1967-1976
Number of pages10
JournalEye (Basingstoke)
Issue number7
Publication statusPublished - 2021 Jul

Bibliographical note

Publisher Copyright:
© 2020, The Author(s), under exclusive licence to The Royal College of Ophthalmologists.

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems


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