Effect of the Number of Micro-Osteoperforations on the Rate of Tooth Movement and Periodontal Response in Mice

Tselmuun Erdenebat, Dong Joon Lee, Su Jung Kim, Yoon Jeong Choi, Eun Jung Kim, Eun Hack Choi, Jing Liu, Chung Ju Hwang, Han Sung Jung, Jung Yul Cha

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1 Citation (Scopus)

Abstract

Accelerated tooth movement can be achieved using micro-osteoperforations (MOPs) to stimulate regeneration of the alveolar bone during minimally invasive surgical trauma. However, there is currently no standardized protocol and limited reports regarding the side effects of MOPs based on biological evidence. This study sought to evaluate the biological effects of the number of MOPs on orthodontic tooth movement (OTM) and the potential risk for root resorption. Male CD1 mice were divided into 4 groups based on the number of MOPs, as follows: Sham; 0MOP+OTM; 2MOP+OTM; and 4MOP+OTM groups. Tooth movement distance and the number of osteoclasts were higher whereas bone volume and trabecular number were lower in the 4MOP+OTM group compared to those of the 0MOP+OTM group. Immunofluorescent assay analysis indicated that the 4MOP+OTM group was positively associated with rapid cementum regeneration and periodontal ligament tissue formation. Our findings revealed that the MOP procedure affected tooth movement and did not significantly contribute to root resorption, whereas it may promote constitutive activation of cementogenesis.

Original languageEnglish
Article number837094
JournalFrontiers in Physiology
Volume13
DOIs
Publication statusPublished - 2022 Mar 3

Bibliographical note

Funding Information:
This research was supported by the Bio and Medical Technology Development Program of the National Research Foundation (NRF) and funded by the Korean Government (MSIP&MOHW) (no. 2017M3A9E4048172).

Publisher Copyright:
Copyright © 2022 Erdenebat, Lee, Kim, Choi, Kim, Choi, Liu, Hwang, Jung and Cha.

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

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