Effect of tranexamic acid on transfusion requirement in dual antiplatelet-treated anemic patients undergoing off-pump coronary artery bypass graft surgery-a randomized controlled study

So Woon Ahn, Jae Kwang Shim, Young Nam Youn, Jong Wook Song, So Young Yang, Sung Chan Chung, Younglan Kwak

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Anemia is not rare in patients presenting for coronary artery bypass graft surgery (CABG) and as these patients are frequently on dual antiplatelet therapy (DAPT), the coexisting conditions could potentially increase the risk of bleeding and transfusion. The aim of this study was to evaluate the effect of tranexamic acid (TA) on blood loss and transfusion in preoperatively anemic patients who continued DAPT until within 5 days of off-pump CABG (OPCAB). Methods and Results: Seventy-six anemic patients were randomized into 2 groups: TA group receiving TA (1 g bolus followed by infusion at 200 mg/h) and a Control group receiving the same volume of saline. The amount of blood loss and transfusion requirement during, and at 4 and 24 h after the operation were assessed. Patients' characteristics and operative data were similar between the groups. During the perioperative period, which combined the intraoperative and postoperative 24 h data, the TA group received significantly smaller amounts of packed red blood cells and fresh frozen plasma. Total amount of perioperative blood loss was similar between the groups, although the blood loss during the postoperative 4 h was significantly less in the TA group. Conclusions: TA infusion could reduce the amount of transfusion during the perioperative period in patients with preoperative anemia who continue DAPT until within 5 days of OPCAB.

Original languageEnglish
Pages (from-to)96-101
Number of pages6
JournalCirculation Journal
Volume76
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

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Tranexamic Acid
Off-Pump Coronary Artery Bypass
Coronary Artery Bypass
Transplants
Perioperative Period
Blood Transfusion
Anemia
Postoperative Hemorrhage
Therapeutics
Erythrocytes
Hemorrhage
Control Groups

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Ahn, So Woon ; Shim, Jae Kwang ; Youn, Young Nam ; Song, Jong Wook ; Yang, So Young ; Chung, Sung Chan ; Kwak, Younglan. / Effect of tranexamic acid on transfusion requirement in dual antiplatelet-treated anemic patients undergoing off-pump coronary artery bypass graft surgery-a randomized controlled study. In: Circulation Journal. 2012 ; Vol. 76, No. 1. pp. 96-101.
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abstract = "Background: Anemia is not rare in patients presenting for coronary artery bypass graft surgery (CABG) and as these patients are frequently on dual antiplatelet therapy (DAPT), the coexisting conditions could potentially increase the risk of bleeding and transfusion. The aim of this study was to evaluate the effect of tranexamic acid (TA) on blood loss and transfusion in preoperatively anemic patients who continued DAPT until within 5 days of off-pump CABG (OPCAB). Methods and Results: Seventy-six anemic patients were randomized into 2 groups: TA group receiving TA (1 g bolus followed by infusion at 200 mg/h) and a Control group receiving the same volume of saline. The amount of blood loss and transfusion requirement during, and at 4 and 24 h after the operation were assessed. Patients' characteristics and operative data were similar between the groups. During the perioperative period, which combined the intraoperative and postoperative 24 h data, the TA group received significantly smaller amounts of packed red blood cells and fresh frozen plasma. Total amount of perioperative blood loss was similar between the groups, although the blood loss during the postoperative 4 h was significantly less in the TA group. Conclusions: TA infusion could reduce the amount of transfusion during the perioperative period in patients with preoperative anemia who continue DAPT until within 5 days of OPCAB.",
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Effect of tranexamic acid on transfusion requirement in dual antiplatelet-treated anemic patients undergoing off-pump coronary artery bypass graft surgery-a randomized controlled study. / Ahn, So Woon; Shim, Jae Kwang; Youn, Young Nam; Song, Jong Wook; Yang, So Young; Chung, Sung Chan; Kwak, Younglan.

In: Circulation Journal, Vol. 76, No. 1, 01.01.2012, p. 96-101.

Research output: Contribution to journalArticle

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T1 - Effect of tranexamic acid on transfusion requirement in dual antiplatelet-treated anemic patients undergoing off-pump coronary artery bypass graft surgery-a randomized controlled study

AU - Ahn, So Woon

AU - Shim, Jae Kwang

AU - Youn, Young Nam

AU - Song, Jong Wook

AU - Yang, So Young

AU - Chung, Sung Chan

AU - Kwak, Younglan

PY - 2012/1/1

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N2 - Background: Anemia is not rare in patients presenting for coronary artery bypass graft surgery (CABG) and as these patients are frequently on dual antiplatelet therapy (DAPT), the coexisting conditions could potentially increase the risk of bleeding and transfusion. The aim of this study was to evaluate the effect of tranexamic acid (TA) on blood loss and transfusion in preoperatively anemic patients who continued DAPT until within 5 days of off-pump CABG (OPCAB). Methods and Results: Seventy-six anemic patients were randomized into 2 groups: TA group receiving TA (1 g bolus followed by infusion at 200 mg/h) and a Control group receiving the same volume of saline. The amount of blood loss and transfusion requirement during, and at 4 and 24 h after the operation were assessed. Patients' characteristics and operative data were similar between the groups. During the perioperative period, which combined the intraoperative and postoperative 24 h data, the TA group received significantly smaller amounts of packed red blood cells and fresh frozen plasma. Total amount of perioperative blood loss was similar between the groups, although the blood loss during the postoperative 4 h was significantly less in the TA group. Conclusions: TA infusion could reduce the amount of transfusion during the perioperative period in patients with preoperative anemia who continue DAPT until within 5 days of OPCAB.

AB - Background: Anemia is not rare in patients presenting for coronary artery bypass graft surgery (CABG) and as these patients are frequently on dual antiplatelet therapy (DAPT), the coexisting conditions could potentially increase the risk of bleeding and transfusion. The aim of this study was to evaluate the effect of tranexamic acid (TA) on blood loss and transfusion in preoperatively anemic patients who continued DAPT until within 5 days of off-pump CABG (OPCAB). Methods and Results: Seventy-six anemic patients were randomized into 2 groups: TA group receiving TA (1 g bolus followed by infusion at 200 mg/h) and a Control group receiving the same volume of saline. The amount of blood loss and transfusion requirement during, and at 4 and 24 h after the operation were assessed. Patients' characteristics and operative data were similar between the groups. During the perioperative period, which combined the intraoperative and postoperative 24 h data, the TA group received significantly smaller amounts of packed red blood cells and fresh frozen plasma. Total amount of perioperative blood loss was similar between the groups, although the blood loss during the postoperative 4 h was significantly less in the TA group. Conclusions: TA infusion could reduce the amount of transfusion during the perioperative period in patients with preoperative anemia who continue DAPT until within 5 days of OPCAB.

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