Effect of Trp64Arg mutation in the β3-adrenoceptor gene on body fat distribution, glycemic control and lipids in response to hypocaloric diets in men with coronary artery disease

Oh Yoen Kim, Yun Ah Lee, Ha Jung Ryu, Hyun Young Park, Yangsoo Jang, Jong Ho Lee

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This study aimed to investigate whether the Trp64Arg mutation of the β3-adrenoceptor gene affects abdominal fat mobilization and endocrinal function in overweight-obese men with coronary artery disease (CAD) during 12 weeks' mild weight reduction (-300kcal/d). Seventy participants were subdivided into 'without-mutation' group and 'with-mutation' group. After the intervention, the average weight and body mass index of the subjects without mutation (n = 50) and with mutation (n = 20) similarly decreased by about 5% (p < 0.001). In without-mutation group, the areas of total and visceral fats at both 1st and 4th lumbar vertebra (L1, L4) and that of subcutaneous fat at L1 level were significantly reduced. Fasting insulin and lipid profiles were also improved only in this group. However, with-mutation group showed a significant reduction only in mid thigh fat area. In conclusion, the Trp64Arg mutation during mild weight reduction makes difficult not only abdominal fat loss but also improvements in insulin and lipid profiles in CAD men despite similar weight reduction in both without- and with-mutation groups.

Original languageEnglish
Pages (from-to)1013-1025
Number of pages13
JournalNutrition Research
Volume23
Issue number8
DOIs
Publication statusPublished - 2003 Aug 1

Fingerprint

Body Fat Distribution
Adrenergic Receptors
Coronary Artery Disease
Diet
Lipids
Mutation
Genes
Weight Loss
Abdominal Fat
Insulin
Lumbar Vertebrae
Intra-Abdominal Fat
Subcutaneous Fat
Thigh
Fasting
Body Mass Index
Fats
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

@article{f366fc928d3f478faf46b05986c3787a,
title = "Effect of Trp64Arg mutation in the β3-adrenoceptor gene on body fat distribution, glycemic control and lipids in response to hypocaloric diets in men with coronary artery disease",
abstract = "This study aimed to investigate whether the Trp64Arg mutation of the β3-adrenoceptor gene affects abdominal fat mobilization and endocrinal function in overweight-obese men with coronary artery disease (CAD) during 12 weeks' mild weight reduction (-300kcal/d). Seventy participants were subdivided into 'without-mutation' group and 'with-mutation' group. After the intervention, the average weight and body mass index of the subjects without mutation (n = 50) and with mutation (n = 20) similarly decreased by about 5{\%} (p < 0.001). In without-mutation group, the areas of total and visceral fats at both 1st and 4th lumbar vertebra (L1, L4) and that of subcutaneous fat at L1 level were significantly reduced. Fasting insulin and lipid profiles were also improved only in this group. However, with-mutation group showed a significant reduction only in mid thigh fat area. In conclusion, the Trp64Arg mutation during mild weight reduction makes difficult not only abdominal fat loss but also improvements in insulin and lipid profiles in CAD men despite similar weight reduction in both without- and with-mutation groups.",
author = "Kim, {Oh Yoen} and Lee, {Yun Ah} and Ryu, {Ha Jung} and Park, {Hyun Young} and Yangsoo Jang and Lee, {Jong Ho}",
year = "2003",
month = "8",
day = "1",
doi = "10.1016/S0271-5317(03)00099-X",
language = "English",
volume = "23",
pages = "1013--1025",
journal = "Nutrition Research",
issn = "0271-5317",
publisher = "Elsevier Inc.",
number = "8",

}

Effect of Trp64Arg mutation in the β3-adrenoceptor gene on body fat distribution, glycemic control and lipids in response to hypocaloric diets in men with coronary artery disease. / Kim, Oh Yoen; Lee, Yun Ah; Ryu, Ha Jung; Park, Hyun Young; Jang, Yangsoo; Lee, Jong Ho.

In: Nutrition Research, Vol. 23, No. 8, 01.08.2003, p. 1013-1025.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of Trp64Arg mutation in the β3-adrenoceptor gene on body fat distribution, glycemic control and lipids in response to hypocaloric diets in men with coronary artery disease

AU - Kim, Oh Yoen

AU - Lee, Yun Ah

AU - Ryu, Ha Jung

AU - Park, Hyun Young

AU - Jang, Yangsoo

AU - Lee, Jong Ho

PY - 2003/8/1

Y1 - 2003/8/1

N2 - This study aimed to investigate whether the Trp64Arg mutation of the β3-adrenoceptor gene affects abdominal fat mobilization and endocrinal function in overweight-obese men with coronary artery disease (CAD) during 12 weeks' mild weight reduction (-300kcal/d). Seventy participants were subdivided into 'without-mutation' group and 'with-mutation' group. After the intervention, the average weight and body mass index of the subjects without mutation (n = 50) and with mutation (n = 20) similarly decreased by about 5% (p < 0.001). In without-mutation group, the areas of total and visceral fats at both 1st and 4th lumbar vertebra (L1, L4) and that of subcutaneous fat at L1 level were significantly reduced. Fasting insulin and lipid profiles were also improved only in this group. However, with-mutation group showed a significant reduction only in mid thigh fat area. In conclusion, the Trp64Arg mutation during mild weight reduction makes difficult not only abdominal fat loss but also improvements in insulin and lipid profiles in CAD men despite similar weight reduction in both without- and with-mutation groups.

AB - This study aimed to investigate whether the Trp64Arg mutation of the β3-adrenoceptor gene affects abdominal fat mobilization and endocrinal function in overweight-obese men with coronary artery disease (CAD) during 12 weeks' mild weight reduction (-300kcal/d). Seventy participants were subdivided into 'without-mutation' group and 'with-mutation' group. After the intervention, the average weight and body mass index of the subjects without mutation (n = 50) and with mutation (n = 20) similarly decreased by about 5% (p < 0.001). In without-mutation group, the areas of total and visceral fats at both 1st and 4th lumbar vertebra (L1, L4) and that of subcutaneous fat at L1 level were significantly reduced. Fasting insulin and lipid profiles were also improved only in this group. However, with-mutation group showed a significant reduction only in mid thigh fat area. In conclusion, the Trp64Arg mutation during mild weight reduction makes difficult not only abdominal fat loss but also improvements in insulin and lipid profiles in CAD men despite similar weight reduction in both without- and with-mutation groups.

UR - http://www.scopus.com/inward/record.url?scp=0041706143&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041706143&partnerID=8YFLogxK

U2 - 10.1016/S0271-5317(03)00099-X

DO - 10.1016/S0271-5317(03)00099-X

M3 - Article

AN - SCOPUS:0041706143

VL - 23

SP - 1013

EP - 1025

JO - Nutrition Research

JF - Nutrition Research

SN - 0271-5317

IS - 8

ER -