TY - GEN
T1 - Effect of vibration on lumbar bone of OVX rats compared with risedronate-dosed rat
AU - Ko, Chang Yong
AU - Lee, Tae Woo
AU - Woo, Dae Gon
AU - Namgung, Bum Seok
AU - Kim, Han Sung
AU - Lee, Beob Yi
PY - 2006
Y1 - 2006
N2 - Many different prevention and treatment regimens have been developed to resolve the growing problem of the osteoporosis. Some researchers showed positive effects of whole body vibration (WBV) on osteoporotic trabecular bones of animals. In the present study, the correlation between the morphological and mechanical characteristics and the treatments (interventions and whole body vibration) was investigated and analyzed. The rats were randomized into 3 groups: CON, DRUG and WBV 45Hz. The DRUG group was administered the risedronate (Actonel, 0.58mg/Kg, 5days/week). The WBV 45Hz group was vibrated on a vibration-plate (magnitude : immpeakpeak, frequency : 45Hz) for 30 minutes every day in 5 days every week. The 4th lumbar on rats was scanned by In-vivo Micro-CT at the week 0 (just before treatment) and the week 8 (after treatment). Structural parameters and moduli of the 4th lumbar, based on two dimensional (2D) scan image data, were investigated and analyzed. The change of quantity and mechanical strength of trabecular bone on WBV 45Hz and DRUG groups were lower than that of CON group. There was no significant deference between WBV 45Hz and DRUG group. The results showed that WBV beneficially affected osteoporotic bones.
AB - Many different prevention and treatment regimens have been developed to resolve the growing problem of the osteoporosis. Some researchers showed positive effects of whole body vibration (WBV) on osteoporotic trabecular bones of animals. In the present study, the correlation between the morphological and mechanical characteristics and the treatments (interventions and whole body vibration) was investigated and analyzed. The rats were randomized into 3 groups: CON, DRUG and WBV 45Hz. The DRUG group was administered the risedronate (Actonel, 0.58mg/Kg, 5days/week). The WBV 45Hz group was vibrated on a vibration-plate (magnitude : immpeakpeak, frequency : 45Hz) for 30 minutes every day in 5 days every week. The 4th lumbar on rats was scanned by In-vivo Micro-CT at the week 0 (just before treatment) and the week 8 (after treatment). Structural parameters and moduli of the 4th lumbar, based on two dimensional (2D) scan image data, were investigated and analyzed. The change of quantity and mechanical strength of trabecular bone on WBV 45Hz and DRUG groups were lower than that of CON group. There was no significant deference between WBV 45Hz and DRUG group. The results showed that WBV beneficially affected osteoporotic bones.
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U2 - 10.1109/ICBPE.2006.348583
DO - 10.1109/ICBPE.2006.348583
M3 - Conference contribution
AN - SCOPUS:46249127872
SN - 8190426249
SN - 9788190426244
T3 - ICBPE 2006 - Proceedings of the 2006 International Conference on Biomedical and Pharmaceutical Engineering
SP - 201
EP - 205
BT - ICBPE 2006 - Proceedings of the 2006 International Conference on Biomedical and Pharmaceutical Engineering
T2 - ICBPE 2006 - 2006 International Conference on Biomedical and Pharmaceutical Engineering
Y2 - 11 December 2006 through 14 December 2006
ER -