Many different prevention and treatment regimens have been developed to resolve the growing problem of the osteoporosis. Some researchers showed positive effects of whole body vibration (WBV) on osteoporotic trabecular bones of animals. In the present study, the correlation between the morphological and mechanical characteristics and the treatments (interventions and whole body vibration) was investigated and analyzed. The rats were randomized into 3 groups: CON, DRUG and WBV 45Hz. The DRUG group was administered the risedronate (Actonel, 0.58mg/Kg, 5days/week). The WBV 45Hz group was vibrated on a vibration-plate (magnitude : immpeakpeak, frequency : 45Hz) for 30 minutes every day in 5 days every week. The 4th lumbar on rats was scanned by In-vivo Micro-CT at the week 0 (just before treatment) and the week 8 (after treatment). Structural parameters and moduli of the 4th lumbar, based on two dimensional (2D) scan image data, were investigated and analyzed. The change of quantity and mechanical strength of trabecular bone on WBV 45Hz and DRUG groups were lower than that of CON group. There was no significant deference between WBV 45Hz and DRUG group. The results showed that WBV beneficially affected osteoporotic bones.