Effect of vibration on lumbar bone of OVX rats compared with risedronate-dosed rat

Chang Yong Ko, Tae Woo Lee, Dae Gon Woo, Bum Seok Namgung, Han Sung Kim, Beob Yi Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Many different prevention and treatment regimens have been developed to resolve the growing problem of the osteoporosis. Some researchers showed positive effects of whole body vibration (WBV) on osteoporotic trabecular bones of animals. In the present study, the correlation between the morphological and mechanical characteristics and the treatments (interventions and whole body vibration) was investigated and analyzed. The rats were randomized into 3 groups: CON, DRUG and WBV 45Hz. The DRUG group was administered the risedronate (Actonel, 0.58mg/Kg, 5days/week). The WBV 45Hz group was vibrated on a vibration-plate (magnitude : immpeakpeak, frequency : 45Hz) for 30 minutes every day in 5 days every week. The 4th lumbar on rats was scanned by In-vivo Micro-CT at the week 0 (just before treatment) and the week 8 (after treatment). Structural parameters and moduli of the 4th lumbar, based on two dimensional (2D) scan image data, were investigated and analyzed. The change of quantity and mechanical strength of trabecular bone on WBV 45Hz and DRUG groups were lower than that of CON group. There was no significant deference between WBV 45Hz and DRUG group. The results showed that WBV beneficially affected osteoporotic bones.

Original languageEnglish
Title of host publicationICBPE 2006 - Proceedings of the 2006 International Conference on Biomedical and Pharmaceutical Engineering
Pages201-205
Number of pages5
DOIs
Publication statusPublished - 2006 Dec 1
EventICBPE 2006 - 2006 International Conference on Biomedical and Pharmaceutical Engineering - Singapore, Singapore
Duration: 2006 Dec 112006 Dec 14

Publication series

NameICBPE 2006 - Proceedings of the 2006 International Conference on Biomedical and Pharmaceutical Engineering

Other

OtherICBPE 2006 - 2006 International Conference on Biomedical and Pharmaceutical Engineering
CountrySingapore
CitySingapore
Period06/12/1106/12/14

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Ko, C. Y., Lee, T. W., Woo, D. G., Namgung, B. S., Kim, H. S., & Lee, B. Y. (2006). Effect of vibration on lumbar bone of OVX rats compared with risedronate-dosed rat. In ICBPE 2006 - Proceedings of the 2006 International Conference on Biomedical and Pharmaceutical Engineering (pp. 201-205). [4155892] (ICBPE 2006 - Proceedings of the 2006 International Conference on Biomedical and Pharmaceutical Engineering). https://doi.org/10.1109/ICBPE.2006.348583