Effectiveness of an organized cervical cancer screening program in Korea: Results from a cohort study

Jae Kwan Jun, Kui Son Choi, Kyu Won Jung, Hoo Yeon Lee, Susan M. Gapstur, Eun Cheol Park, Keun Young Yoo

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Abstract

Although the value of cervical cancer screening is widely acknowledged, the effectiveness of an organized cervical cancer screening program in Korea has never been evaluated. We investigated the associations of the frequency of cervical cancer screening with cervical cancer incidence using data from a large prospective cohort study. In this analysis, 253,472 women without a hysterectomy or previous cancer diagnosis were included. Follow-up was between 1995 and 2002. Frequency of Pap smear testing was determined by searching the National Health Examination Database. Using the Korean Central Cancer Registry, 248 cases of invasive cervical cancer and 346 cases of carcinoma in situ (CIS) of the cervix were identified. Subjects screened 2 or more times showed a 71% (corrected reduction 60%) and a 66% (corrected reduction 53%) reduced risk of invasive cervical cancer and CIS of the cervix, respectively, as compared with unscreened subjects [relative risk (RR) = 0.29; 95% confidence interval (CI) = 0.20-0.45; RR = 0.34; 95% CI = 0.25-0.46, respectively]. Women with a normal or benign pap smear had a statistically significantly lower risk of invasive cervical cancer and CIS of cervix compared with those never screened. In age-stratified analyses, there was a significant reduction in cervical cancer incidence among women aged 30 and over who were screened 2 or more times compared with women never screened. The results of this prospective cohort study show that regular screening of cervical cancer reduces invasive cervical cancer incidence and CIS of the cervix among Korean women.

Original languageEnglish
Pages (from-to)188-193
Number of pages6
JournalInternational Journal of Cancer
Volume124
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1

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Korea
Early Detection of Cancer
Uterine Cervical Neoplasms
Cohort Studies
Carcinoma in Situ
Cervix Uteri
Papanicolaou Test
Incidence
Prospective Studies
Confidence Intervals
Hysterectomy
Registries
Neoplasms
Databases
Health

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Jun, Jae Kwan ; Choi, Kui Son ; Jung, Kyu Won ; Lee, Hoo Yeon ; Gapstur, Susan M. ; Park, Eun Cheol ; Yoo, Keun Young. / Effectiveness of an organized cervical cancer screening program in Korea : Results from a cohort study. In: International Journal of Cancer. 2009 ; Vol. 124, No. 1. pp. 188-193.
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Effectiveness of an organized cervical cancer screening program in Korea : Results from a cohort study. / Jun, Jae Kwan; Choi, Kui Son; Jung, Kyu Won; Lee, Hoo Yeon; Gapstur, Susan M.; Park, Eun Cheol; Yoo, Keun Young.

In: International Journal of Cancer, Vol. 124, No. 1, 01.01.2009, p. 188-193.

Research output: Contribution to journalArticle

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