Effectiveness of cross-linked human acellular dermal matrix in primary and revision augmentation rhinoplasty

Sang Chul Park, Jae Sung Nam, Kyu In Lee, Young Woo Lee, Jeong Jin Park, Jong Gyun Ha, Hyung Ju Cho, Joo Heon Yoon, Chang Hoon Kim

Research output: Contribution to journalArticlepeer-review


Background: Among the materials used for dorsal augmentation rhinoplasty (DAR), cross-linked human acellular dermal matrix (ADM) has been claimed for its low risk of infection and extrusion. The aim of this study was to compare the effectiveness of ADM in subjects undergoing primary versus revision dorsal augmentation rhinoplasties. Methods: Using a retrospective cohort study design, the investigators enrolled a cohort set of DAR patients operated by a single surgeon during a 65-month interval. The predictor variable was the treatment group (primary or revision DAR). The main outcome variables were postoperative changes with regard to the degree of augmentation (ratio of the dorsal height [DH] and radix height [RH] to the nasal length) and patients’ and surgeons’ satisfaction with the aesthetic and functional results. Other study variables were grouped into the following categories: demographic, surgical, and pathological. Descriptive, uni-, and bivariate statistics were computed using P ≤ 0.05 as a cutoff value. Results: The study cohort comprised 145 subjects (75.2% with primary DAR; 39.3% females) with a mean age of 30.7 ± 9.4 years (range, 19–58). DAR was linked to the significant changes in DH and RH in both the treatment groups. Comparison of the two groups revealed that there was no significant difference in DH and RH between both the groups. Surgeons’ and patients’ satisfaction rates were comparable between the two surgery groups, neither of which experienced serious complications. Microscopic findings of the removed ADM showed abundant collagen tissue with newly formed vessels without signs of foreign body reaction. Conclusion: Despite significant differences in patient characteristics (age; number of osteotomy, tip plasty, and hump reduction surgeries), the results of this study suggest that ADM can be used in both primary and revision DAR, with minimal complications.

Original languageEnglish
Pages (from-to)1447-1454
Number of pages8
JournalJournal of Plastic, Reconstructive and Aesthetic Surgery
Issue number4
Publication statusPublished - 2022 Apr

Bibliographical note

Funding Information:
This research was supported by Korea Mouse Phenotyping Project of the Ministry of Science and ICT (MSIT) through the National Research Foundation (NRF) (No. 2016M3A9D5A01952414 ), NRF grant funded by the Korean government (MSIT) (No. 2016R1A5A2008630 ), and NRF grant funded by the Korean government (MSIT) (No. 2019R1A2C1089841 ). This work was also supported by the Basic Science Research Program through the NRF funded by the Ministry of Education ( 2020R1I1A3067369 ).

Publisher Copyright:
© 2021

All Science Journal Classification (ASJC) codes

  • Surgery


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