Effectiveness of Fimasartan and Rosuvastatin Combination Treatment in Hypertensive Patients With Dyslipidemia

Seung Jun Lee, Jaewon Oh, Sung Jin Hong, In Jeong Cho, Su Rae Kim, Jae Sun Uhm, Chi Young Shim, Hyuk Jae Chang, Chul Min Ahn, Jung Sun Kim, Byeong Keuk Kim, Sungha Park, Sang Hak Lee, Geu Ru Hong, Young Guk Ko, Donghoon Choi

Research output: Contribution to journalArticle

Abstract

Purpose: The goal of this study was to evaluate the concurrent control rate of hypertension and dyslipidemia by fimasartan and rosuvastatin in patients who were concomitantly prescribed both drugs. Methods: : This single-center, cross-sectional study was conducted in 536 patients with hypertension and dyslipidemia who were taking fimasartan and rosuvastatin together for at least 12 weeks. Patients were enrolled from October 2016 to March 2018 at a tertiary hospital in the Republic of Korea. The primary end point was the concurrent control rate of blood pressure (<140/90 mm Hg) and LDL-C. As a secondary end point, the target blood pressure <130/80 mm Hg was adopted in all patients or in high-risk patients with atherosclerotic cardiovascular diseases. Target LDL-C and non–HDL-C levels followed the domestic guidelines. Correlation between blood pressure control and lipid profile was also evaluated. All parameters were assessed in a clinic by board-certified physicians. Findings: Of the total 536 patients, 69% (n = 368) had very high (n = 308) or high (n = 60) cardiovascular risk, with an average age of 65 years; 57% were male. When the target blood pressure was set at 140/90 mm Hg, the proportion of patients meeting the targeting LDL-C level was 40.3% (95% CI, 36.2–44.5; P < 0.001). When applied to the revised blood pressure criteria targeting 130/80 mm Hg, the concurrent control rate dropped by one half to 20.3% (95% CI, 17.2–24.0; P < 0.001). To apply the new blood pressure criteria, more intensive management is mandatory in patients with high or very high cardiovascular risk. There was no positive correlation between the controlled rate of hypertension and dyslipidemia. Implications: Fimasartan and rosuvastatin were shown to have effects on target diseases, but there was no synergistic effect when administered in combination. The higher the cardiovascular risk of the patients, the lower the rate of concurrent control when fimasartan and rosuvastatin were administered simultaneously. More active treatment is therefore required in high-risk patients.

Original languageEnglish
Pages (from-to)1058-1066.e3
JournalClinical Therapeutics
Volume42
Issue number6
DOIs
Publication statusPublished - 2020 Jun

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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    Lee, S. J., Oh, J., Hong, S. J., Cho, I. J., Kim, S. R., Uhm, J. S., Shim, C. Y., Chang, H. J., Ahn, C. M., Kim, J. S., Kim, B. K., Park, S., Lee, S. H., Hong, G. R., Ko, Y. G., & Choi, D. (2020). Effectiveness of Fimasartan and Rosuvastatin Combination Treatment in Hypertensive Patients With Dyslipidemia. Clinical Therapeutics, 42(6), 1058-1066.e3. https://doi.org/10.1016/j.clinthera.2020.03.019