Effectiveness of mass drug administration on neglected tropical diseases in schoolchildren in Zanzibar, Tanzania

Ju Yeong Kim, Seobo Sim, Eun Joo Chung, Han Jong Rim, Jong Yil Chai, Duk Young Min, Keeseon S. Eom, Khalfan A. Mohammed, Iddi S. Khamis, Tai Soon Yong

Research output: Contribution to journalArticle

Abstract

Soil-transmitted helminths and Schistosoma haematobium affect more than 3 billion people globally and mainly occur in sub-Saharan Africa. The present study assessed the overall infection status of a 1716-student cohort of schoolchildren in Zanzibar and applied mass drug administration (MDA) to the cohort from 2007 to 2009. Schools in Pemba, Zanzibar, had a much higher prevalence of soil-transmitted helminth infections than those in Unguja, and the Chaani, Ghana, and Machui schools of Unguja exhibited high S. haematobium infection rates. The MDA program only partially controlled parasite infections, owing to high rates of re-infection. The infection rate of S. haematobium across all 10 schools, for example, was only reduced by 1.8%, and even this change not significant, even though the S. haematobium infection rates of the Chaani and Mzambarauni schools were significantly reduced from 64.4 and 23.4%, respectively, at the first screening, to 7.3 and 2.3% at the last screening. The overall infection rate of Ascaris lumbricoides was reduced from 36.0% at the first screening to 22.6% at the last screening. However, the infection rates for both Trichuris trichiura and hookworm were generally unaffected by MDA. In the future, parasite control programs should involve strategically designed MDA schedules and holistic intervention (e.g., sanitation improvement, hygiene behavior changes, and control of intermediated hosts).

Original languageEnglish
Pages (from-to)109-119
Number of pages11
JournalKorean Journal of Parasitology
Volume58
Issue number2
DOIs
Publication statusPublished - 2020 Apr

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Effectiveness of mass drug administration on neglected tropical diseases in schoolchildren in Zanzibar, Tanzania'. Together they form a unique fingerprint.

  • Cite this

    Kim, J. Y., Sim, S., Chung, E. J., Rim, H. J., Chai, J. Y., Min, D. Y., Eom, K. S., Mohammed, K. A., Khamis, I. S., & Yong, T. S. (2020). Effectiveness of mass drug administration on neglected tropical diseases in schoolchildren in Zanzibar, Tanzania. Korean Journal of Parasitology, 58(2), 109-119. https://doi.org/10.3347/kjp.2020.58.2.109