Effectiveness of micro-current electrical stimulation for treating rheumatoid arthritis

Seo Hyun Kim, Hana Lee, Dong Hyun Hwang, Dong Hyun Seo, Han Sung Kim, Seungkwan Cho

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Induction of micro-current in subject is known to be effective on the treatment of inflammatory disease. Thus, this study evaluated that the micro-current electrical treatment (MET) can reduce rheumatoid arthritis (RA), which is one of inflammatory disease, and tried to find optimized level of current for treatment. 55 male 11-week-old C57BL/6 mice were used and randomly allocated into five groups; normal group (N; n=11), the group of induced RA (C; n=11) and three groups of induced RA with MET (M) using different levels of current by 22 μA, 50 μA, and 400 μA (22M, 50M and 400M; n=11, respectively). MET was carried out for 1 hour each day. Both 3rd metatarsal (3rd MT) and tarsal (T) were scanned by in-vivo micro computed tomography (micro-CT) at 0week and after 3weeks in order to obtain structural parameters including BMD (Bone mineral density), BV (Bone volume) and Obj.N (Mean number of objects per slice). In M groups, all the measured parameters after 3 weeks were significantly higher than those of C group regardless of the current levels. However, there is no significant difference among the different levels of electrical current at 3week. These results indicated that the MET may be effective on the treatment of RA. However, we cannot assure the optimized level of current to treat RA tremendously.

Original languageEnglish
Title of host publication2016 IEEE EMBS International Student Conference
Subtitle of host publicationExpanding the Boundaries of Biomedical Engineering and Healthcare, ISC 2016 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781509009350
DOIs
Publication statusPublished - 2016 Jul 8
Event2016 IEEE EMBS International Student Conference, ISC 2016 - Ottawa, Canada
Duration: 2016 May 292016 May 31

Other

Other2016 IEEE EMBS International Student Conference, ISC 2016
CountryCanada
CityOttawa
Period16/5/2916/5/31

Fingerprint

Electric Stimulation
Rheumatoid Arthritis
Bone
Tomography
Minerals
Group
Metatarsal Bones
Disease
Inbred C57BL Mouse
Bone Density
induction
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Genetics
  • Health(social science)
  • Biomedical Engineering

Cite this

Kim, S. H., Lee, H., Hwang, D. H., Seo, D. H., Kim, H. S., & Cho, S. (2016). Effectiveness of micro-current electrical stimulation for treating rheumatoid arthritis. In 2016 IEEE EMBS International Student Conference: Expanding the Boundaries of Biomedical Engineering and Healthcare, ISC 2016 - Proceedings [7508615] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBSISC.2016.7508615
Kim, Seo Hyun ; Lee, Hana ; Hwang, Dong Hyun ; Seo, Dong Hyun ; Kim, Han Sung ; Cho, Seungkwan. / Effectiveness of micro-current electrical stimulation for treating rheumatoid arthritis. 2016 IEEE EMBS International Student Conference: Expanding the Boundaries of Biomedical Engineering and Healthcare, ISC 2016 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2016.
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abstract = "Induction of micro-current in subject is known to be effective on the treatment of inflammatory disease. Thus, this study evaluated that the micro-current electrical treatment (MET) can reduce rheumatoid arthritis (RA), which is one of inflammatory disease, and tried to find optimized level of current for treatment. 55 male 11-week-old C57BL/6 mice were used and randomly allocated into five groups; normal group (N; n=11), the group of induced RA (C; n=11) and three groups of induced RA with MET (M) using different levels of current by 22 μA, 50 μA, and 400 μA (22M, 50M and 400M; n=11, respectively). MET was carried out for 1 hour each day. Both 3rd metatarsal (3rd MT) and tarsal (T) were scanned by in-vivo micro computed tomography (micro-CT) at 0week and after 3weeks in order to obtain structural parameters including BMD (Bone mineral density), BV (Bone volume) and Obj.N (Mean number of objects per slice). In M groups, all the measured parameters after 3 weeks were significantly higher than those of C group regardless of the current levels. However, there is no significant difference among the different levels of electrical current at 3week. These results indicated that the MET may be effective on the treatment of RA. However, we cannot assure the optimized level of current to treat RA tremendously.",
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Kim, SH, Lee, H, Hwang, DH, Seo, DH, Kim, HS & Cho, S 2016, Effectiveness of micro-current electrical stimulation for treating rheumatoid arthritis. in 2016 IEEE EMBS International Student Conference: Expanding the Boundaries of Biomedical Engineering and Healthcare, ISC 2016 - Proceedings., 7508615, Institute of Electrical and Electronics Engineers Inc., 2016 IEEE EMBS International Student Conference, ISC 2016, Ottawa, Canada, 16/5/29. https://doi.org/10.1109/EMBSISC.2016.7508615

Effectiveness of micro-current electrical stimulation for treating rheumatoid arthritis. / Kim, Seo Hyun; Lee, Hana; Hwang, Dong Hyun; Seo, Dong Hyun; Kim, Han Sung; Cho, Seungkwan.

2016 IEEE EMBS International Student Conference: Expanding the Boundaries of Biomedical Engineering and Healthcare, ISC 2016 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2016. 7508615.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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N2 - Induction of micro-current in subject is known to be effective on the treatment of inflammatory disease. Thus, this study evaluated that the micro-current electrical treatment (MET) can reduce rheumatoid arthritis (RA), which is one of inflammatory disease, and tried to find optimized level of current for treatment. 55 male 11-week-old C57BL/6 mice were used and randomly allocated into five groups; normal group (N; n=11), the group of induced RA (C; n=11) and three groups of induced RA with MET (M) using different levels of current by 22 μA, 50 μA, and 400 μA (22M, 50M and 400M; n=11, respectively). MET was carried out for 1 hour each day. Both 3rd metatarsal (3rd MT) and tarsal (T) were scanned by in-vivo micro computed tomography (micro-CT) at 0week and after 3weeks in order to obtain structural parameters including BMD (Bone mineral density), BV (Bone volume) and Obj.N (Mean number of objects per slice). In M groups, all the measured parameters after 3 weeks were significantly higher than those of C group regardless of the current levels. However, there is no significant difference among the different levels of electrical current at 3week. These results indicated that the MET may be effective on the treatment of RA. However, we cannot assure the optimized level of current to treat RA tremendously.

AB - Induction of micro-current in subject is known to be effective on the treatment of inflammatory disease. Thus, this study evaluated that the micro-current electrical treatment (MET) can reduce rheumatoid arthritis (RA), which is one of inflammatory disease, and tried to find optimized level of current for treatment. 55 male 11-week-old C57BL/6 mice were used and randomly allocated into five groups; normal group (N; n=11), the group of induced RA (C; n=11) and three groups of induced RA with MET (M) using different levels of current by 22 μA, 50 μA, and 400 μA (22M, 50M and 400M; n=11, respectively). MET was carried out for 1 hour each day. Both 3rd metatarsal (3rd MT) and tarsal (T) were scanned by in-vivo micro computed tomography (micro-CT) at 0week and after 3weeks in order to obtain structural parameters including BMD (Bone mineral density), BV (Bone volume) and Obj.N (Mean number of objects per slice). In M groups, all the measured parameters after 3 weeks were significantly higher than those of C group regardless of the current levels. However, there is no significant difference among the different levels of electrical current at 3week. These results indicated that the MET may be effective on the treatment of RA. However, we cannot assure the optimized level of current to treat RA tremendously.

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Kim SH, Lee H, Hwang DH, Seo DH, Kim HS, Cho S. Effectiveness of micro-current electrical stimulation for treating rheumatoid arthritis. In 2016 IEEE EMBS International Student Conference: Expanding the Boundaries of Biomedical Engineering and Healthcare, ISC 2016 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2016. 7508615 https://doi.org/10.1109/EMBSISC.2016.7508615